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慢性阻塞性肺疾病并肌少症相关的研究进展
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Abstract:
慢性阻塞性肺疾病简称慢阻肺(COPD)是常见的慢性呼吸系统疾病之一，是一种复杂的、具有高度异质性的全身性疾病。肌少症是一种以骨骼肌质量下降和功能减退特点的退行性病变。慢性阻塞性肺疾病病人更易并发肌少症，能够加速慢阻肺疾病进程，增加致残率和死亡率。然而目前只能靠双能X线和BIA确诊，部分医院及社区不能普及，导致慢阻肺肌少症患者漏诊。因此，本文结合最新文献就慢性阻塞性肺疾病相关肌少症的流行病学、发病机制、筛查诊断予以综述。
Chronic obstructive pulmonary disease (COPD) is one of the common chronic respiratory diseases. It is a complex systemic disease with high heterogeneity. Sarcopenia is a degenerative disease char-acterized by a decline in skeletal muscle mass and function. Patients with chronic obstructive pul-monary disease are more susceptible to sarcopenia, which can accelerate the disease process and increase disability and all-cause mortality. However, at present, the diagnosis can only be made by dual-energy X-ray and BIA, which can not be popularized in some hospitals and communities, re-sulting in missed diagnosis of COPD patients with sarcopenia. Therefore, the epidemiology, patho-genesis, screening and diagnosis of sarcopenia associated with chronic obstructive pulmonary dis-ease were reviewed in this paper.
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