Endometrial Cancer: Epidemiological, Histological and Therapeutic Aspects in the Gynecology-Obstetrics Department of the Donka National Hospital, CHU of Conakry
Objective: To study the epidemiological, histological and therapeutic
characteristics of endometrial cancer in the
Gynecology-Obstetrics department of the Donka National Hospital, CHU of
Conakry. Methods: We conducted a retrospective descriptive study of 86
patients with endometrial cancer treated in the Gynecology-Obstetrics
department of the Donka National Hospital from January 1, 2011, to December 31,
2021, based on their medical records. We analysed the epidemiological,
histological and therapeutic aspects of the disease. Results: Endometrial cancer accounted for 3.1% of the 2793 gynecological pathology cases
registered in the department during the study period, ranking third. The mean
age of the patients was 63 ±5 years.
Most of them were uneducated (59.3%), postmenopausal
(91.9%), nulliparous (30.2%), obese (65.1%) and hypertensive (77.1%).
More than half of the patients (53.4%) were diagnosed at stage I. Endometrioid
adenocarcinoma was the predominant histological type (68.6%). Surgery was
performed in 96.6% of the patients, and chemotherapy in 14.0%. After a mean
follow-up of 15 months, 84.5% of the patients were alive. Conclusion: Endometrial cancer is a common gynecological malignancy in our department.
Endometrioid adenocarcinoma is the most frequent histological subtype. Surgery
is the main treatment modality.
References
[1]
Deluche, E., Marti, C., Jochum, F., Bendifallah, S., Azaïs, H., Deidier, J., et al. (2023) Application in France of the 2021 European Recommendations on Endometrial Cancer. Bulletin du Cancer (Paris), 110, 55-68.
https://doi.org/10.1016/j.bulcan.2022.11.003
[2]
Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D.M., Piñeros, M., et al. (2019) Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods. International Journal of Cancer, 144, 1941-1953.
https://doi.org/10.1002/ijc.31937
[3]
Lansac, J., Lecomte, P. and Marret, H. (2007) Gynecology for the Practitioner. 8th Edition, Masson, Paris, 581 p.
[4]
Sobel, M., Simpson, A.N. and Ferguson, S.E. (2021) Endometrial Cancer. CMAJ, 193, E1750-E1751. https://doi.org/10.1503/cmaj.202731-f
[5]
Engbang, N.J.P., Essome, H., Tchente, N.C., Essam, S.J.D., Elono, F.A.M., Ateba, G.R., et al. (2015) Endometrial Cancer in Cameroon: Histo-Epidemiological Profile of 176 Cases. Journal Africain du Cancer, 7, 218-222.
https://doi.org/10.1007/s12558-015-0407-4
[6]
Ouédraogo, A.S., Sanou-Lamien, A.M., Ouédraogo-Tiendrébéogo, R., Ramde, N., et al. (2011) Histoepidemiological Aspects of Endometrial Cancer in Ouagadougou. Journal Africain du Cancer, 3, 251-255. https://doi.org/10.1007/s12558-011-0191-8
[7]
Dem, A., Traoré, B., Dieng, M., Diop, P., Ouajdi, T., Lalami, M., et al. (2008) Gynecological and Breast Cancers at the Cancer Institute of Dakar. Sante, 18, 25-29.
[8]
Burke, W.M., Orr, J., Leitao, M., Salom, E., Gehrig, P., Olawaiye, A.B., et al. (2014) Endometrial Cancer: A Review and Current Management Strategies: Part II. Gynecologic Oncology, 134, 393-402. https://doi.org/10.1016/j.ygyno.2014.06.003
[9]
Arend, R.C., Jones, B.A., Martinez, A. and Goodfellow, P. (2018) Endometrial Cancer: Molecular Markers and Management of Advanced Stage Disease. Gynecologic Oncology, 150, 569-580. https://doi.org/10.1016/j.ygyno.2018.05.015
[10]
Chekman, C., Gouarek, F., Bouyid, A., Akbal, K. and Bentabak, K. (2020) Endometrial Cancer. Algerian Medical Journal, 32, 203.
[11]
Alexandre, J., Le frere-Belda, M.A., Prulhiere, K., Treilleux, I. and Leary, A. (2020) Nice-Saint-Paul de Vence 2020 Recommendations for Clinical Practice: Management of Metastatic and/or Relapsing Endometrial Cancer. Bulletin du Cancer (Paris), 107, 1006-1018.
[12]
Scattarelli, A., Poteau, A., Aziz, M., Lae, M., Courville, P., Arnaud, M., et al. (2020) Evaluation of Non-Endometrial Endometrial Cancer Guidelines: A Retrospective Multicentre Study. Taurus & Cancer 107, 122-132.
https://doi.org/10.1016/j.bulcan.2020.08.006
[13]
Giede, C., Tien Le, S. and Power, P. (2013) Role of Surgery in Endometrial Cancer. Journal of Obstetrics and Gynaecology Canada, 35, 370-371.
https://doi.org/10.1016/S1701-2163(15)30966-X
[14]
Leary, A. and Abu-Rustum, N. (2016) Endometrial Cancer. The Lancet, 387, 1094-1108. https://doi.org/10.1016/S0140-6736(15)00130-0
[15]
Lheureux, S. and Joly, F. (2012) Endometrial Cancer: Place for Adjuvant Chemotherapy. Taurus & Cancer, 99, 85-91. https://doi.org/10.1684/bdc.2011.1518