Background:Trichomoniasis is the most common non-viral sexually
transmitted infection (STI) in the world, and the occurrence of this infection
during pregnancy is responsible for adverse obstetrical outcomes like premature
labor, premature rupture of membranes (PROM) and low birth weight (birth weight
< 2500 g). The association with a number of factors (maternal age, low level
of education, low socio-economic status and multiple sexual partners, etc.)
that can be found in our environment suggest its probably high prevalence
amongst vaginal infections that are responsible for adverse obstetrical
outcomes, but up-to-date estimates are lacking. Objective: To assess the
obstetrical risk associated with Trichomonas
vaginalis (T. vaginalis)
infection in our environment. Methods: We designed a protocol for a
prospective cohort study which will take place in four medical facilities in
the city of Kinshasa, where all pregnant women with a pregnancy of at least 20
weeks and who will give written consent will
be included. Vaginal swab specimens will be collected for T. vaginalis research by direct
microscopy wet mount. Follow-up will consist of recording the process of the
pregnancy and obstetrical outcomes. Conclusion: Results from this study
will allow to enhance management and also bring updated estimates on T. vaginalis prevalence and its
obstetrical outcomes for infected pregnant woman in our environment.
References
[1]
Meites, E., Gaydos, C.A., Hobbs, M.M., Kissinger, P., Nyirjesy, P., Schwebke, J.R., et al. (2015) A Review of Evidence-Based Care of Symptomatic Trichomoniasis and Asymptomatic Trichomonas vaginalis Infections. Clinical Infectious Diseases, 61, S837-S848. https://doi.org/10.1093/cid/civ738
[2]
Nateghi Rostam, M., Hossein Rashidi, B., Habibi, A., et al. (2017) Genital Infections and Reproductive Complications Associated with Trichomonas vaginalis, Neisseria gonorrhoeae, and Streptococcus agalactiae in Women of Qom, Central Iran. International Journal of Research in Marketing, 15, 357-366.
[3]
Graves, K.J., Novak, J., Secor, W.E., Kissinger, P.J., Schwebke, J.R. and Muzny, C.A. (2020) A Systematic Review of the Literature on Mechanisms of 5-Nitroimidazole Resistance in Trichomonas vaginalis. Parasitology, 147, 1383-1391.
https://doi.org/10.1017/S0031182020001237
[4]
Rowley, J., Vander Hoorn, S., Korenromp, E., Low, N., Unemo, M., Abu-Raddad, L.J., et al. (2019) Chlamydia, Gonorrhoea, Trichomoniasis and Syphilis: Global Prevalence and Incidence Estimates, 2016. Bulletin of the World Health Organization, 97, 548-562. https://doi.org/10.2471/BLT.18.228486
[5]
Davey, D.J., Shull, H., Billings, J., Wang, D., Adachi, K. and Klausner, J. (2016) Prevalence of Curable Sexually Transmitted Infections in Pregnant Women in Low- and Middle-Income Countries from 2010 to 2015. Sexually Transmitted Diseases, 43, 450-458. https://doi.org/10.1097/OLQ.0000000000000460
[6]
López-Monteon, A., Gómez-Figueroa, F.S., Ramos-Poceros, G., Guzmán-Gómez, D. and Ramos-Ligonio, A. (2013) Codetection of Trichomonas vaginalis and Candida albicans by PCR in Urine Samples in a Low-Risk Population Attended in a Clinic First Level in Central Veracruz, Mexico. BioMed Research International, 2013, Article ID: 281892. https://doi.org/10.1155/2013/281892
[7]
Wangnapi, R.A., Soso, S., Unger, H.W., Sawera, C., Ome, M., Umbers, A.J., et al. (2015) Prevalence and Risk Factors for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis Infection in Pregnant Women in Papua New Guinea. Sexually Transmitted Infections, 91, 194-200.
https://doi.org/10.1136/sextrans-2014-051670
[8]
Price, C.M., Peters, R.P.H., Steyn, J., Mudau, M., Olivier, D., De Vos, L., et al. (2018) Prevalence and Detection of Trichomonas vaginalis in HIV-Infected Pregnant Women. Sexually Transmitted Diseases, 45, 332-336.
https://doi.org/10.1097/OLQ.0000000000000756
[9]
Teasdale, C.A., Abrams, E.J., Chiasson, M.A., Justman, J., Blanchard, K. and Jones, H.E. (2018) Incidence of Sexually Transmitted Infections during Pregnancy. PLOS ONE, 13, e0197696. https://doi.org/10.1371/journal.pone.0197696
[10]
Van Gerwen, O.T. and Muzny, C.A. (2019) Recent Advances in the Epidemiology, Diagnosis, and Management of Trichomonas vaginalis Infection. F1000Res, 8, Article 1666. https://doi.org/10.12688/f1000research.19972.1
[11]
Radonjic, I.V., Dzamic, A.M., Mitrovic, S.M., Arsic Arsenijevic, V.S., Popadic, D.M. and Kranjcic Zec, I.F. (2006) Diagnosis of Trichomonas vaginalis Infection: The Sensitivities and Specificities of Microscopy, Culture and PCR Assay. European Journal of Obstetrics & Gynecology and Reproductive Biology, 126, 116-120.
https://doi.org/10.1016/j.ejogrb.2005.07.033
[12]
Perazzi, B.E., Menghi, C.I., Coppolillo, E.F., Gatta, C., Eliseth, M.C., de Torres, R.A., et al. (2010) Prevalence and Comparison of Diagnostic Methods for Trichomonas vaginalis Infection in Pregnant Women in Argentina. The Korean Journal of Parasitology, 48, 61-65. https://doi.org/10.3347/kjp.2010.48.1.61
[13]
Hobbs, M.M. and Seña, A.C. (2013) Modern Diagnosis of Trichomonas vaginalis Infection. Sexually Transmitted Infections, 89, 434-438.
https://doi.org/10.1136/sextrans-2013-051057
[14]
Workowski, K.A. and Bolan, G.A. (2015) Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR Recommendations and Reports, 64, 1-137.
[15]
Lazenby, G.B., Soper, D.E. and Nolte, F.S. (2013) Correlation of Leukorrhea and Trichomonas vaginalis Infection. Journal of Clinical Microbiology, 51, 2323-2327.
https://doi.org/10.1128/JCM.00416-13
[16]
Silver, B.J., Guy, R.J., Kaldor, J.M., Jamil, M.S. and Rumbold, A.R. (2014) Trichomonas vaginalis as a Cause of Perinatal Morbidity: A Systematic Review and Meta-Analysis. Sexually Transmitted Diseases, 41, 369-376.
https://doi.org/10.1097/OLQ.0000000000000134
[17]
Mielczarek, E. and Blaszkowska, J. (2016) Trichomonas vaginalis: Pathogenicity and Potential Role in Human Reproductive Failure. Infection, 44, 447-458.
https://doi.org/10.1007/s15010-015-0860-0
Mann, J.R., McDermott, S. and Gill, T. (2010) Sexually Transmitted Infection Is Associated with Increased Risk of Preterm Birth in South Carolina Women Insured by Medicaid. The Journal of Maternal-Fetal & Neonatal Medicine, 23, 563-568.
https://doi.org/10.3109/14767050903214574
[20]
Carter, J.E. and Whithaus, K.C. (2008) Neonatal Respiratory Tract Involvement by Trichomonas vaginalis: A Case Report and Review of the Literature. The American Journal of Tropical Medicine and Hygiene, 78, 17-19.
https://doi.org/10.4269/ajtmh.2008.78.17
[21]
Trintis, J., Epie, N., Boss, R. and Riedel, S. (2010) Neonatal Trichomonas vaginalis Infection: A Case Report and Review of Literature. International Journal of STD & AIDS, 21, 606-607. https://doi.org/10.1258/ijsa.2010.010174
[22]
Eu, P., Ca, G., Zr, P., Tc, Q. and Aar, T. (2021) Prevalence and Correlates of Trichomonas vaginalis Infection among Men and Women in the United States. Clinical Infectious Diseases, 67, 211-217.
https://facultyopinions.com/prime/732868503
[23]
Wang, X. and Ji, X. (2020) Sample Size Estimation in Clinical Research: From Randomized Controlled Trials to Observational Studies. Chest, 158, S12-S20.
https://doi.org/10.1016/j.chest.2020.03.010
[24]
Mbangama, A.M., Tandu-Umba, B. and Mbungu, R.M. (2018) Rationale of a Cohort Study on Risk of Obstetrical Outcomes Associated with Iron Supplementation during Pregnancy. Open Journal of Obstetrics and Gynecology, 8, 598-609.
https://doi.org/10.4236/ojog.2018.86066
[25]
Secor, W.E., Meites, E., Starr, M.C. and Workowski, K.A. (2014) Neglected Parasitic Infections in the United States: Trichomoniasis. American Journal of Tropical Medicine and Hygiene, 90, 800-804. https://doi.org/10.4269/ajtmh.13-0723
[26]
Muzny, C.A. (2018) Why Does Trichomonas vaginalis Continue to be a “Neglected” Sexually Transmitted Infection? Clinical Infectious Diseases, 67, 218-220.
https://doi.org/10.1093/cid/ciy085
[27]
Sutton, M.Y., Sternberg, M., Nsuami, M., Behets, F., Nelson, A.M. and St. Louis, M.E. (1999) Trichomoniasis in Pregnant Human Immunodeficiency Virus-Infected and Human Immunodeficiency Virus-Uninfected Congolese Women: Prevalence, Risk Factors, and Association with Low Birth Weight. American Journal of Obstetrics and Gynecology, 181, 656-662. https://doi.org/10.1016/S0002-9378(99)70509-0
[28]
Laga, M., Alary, M., Behets, F., Goeman, J., Piot, P., Nzila, N., et al. (1994) Condom Promotion, Sexually Transmitted Diseases Treatment, and Declining Incidence of HIV-1 Infection in Female Zairian Sex Workers. The Lancet, 344, 246-248.
https://doi.org/10.1016/S0140-6736(94)93005-8
[29]
Nzila, N., Laga, M., Thiam, M.A., Mayimona, K., Edidi, B., Dyck, E.V., et al. (1991) HIV and Other Sexually Transmitted Diseases among Female Prostitutes in Kinshasa. AIDS, 5, 715-722. https://doi.org/10.1097/00002030-199106000-00011