The aim of this study was to use a meta-analytic approach to evaluate the effect of commercially available yeast probiotic “Actisaf®;？Sc 47” (Saccharomyces cerevisiae CNCM I-4407) produced and marketed by Phileo by Lesaffre on milk performance in dairy cows. Data from 22 trials including 17 with parallel designs and 5 with cross-over designs were collected, and only data with parallel designs were analyzed. From those trials, 4 are published and 13 are from technical reports. In total, 34 comparisons and 1074 dairy cows met the criteria for inclusion in the final analysis of milk yield (MY). For energy corrected milk (ECM), six trials with 12 comparisons and 476 dairy cows met the criteria for inclusion in the final analysis. Because the data are from different trials with different conditions, the statistical model defined includes the fixed effect of the treatment (with vs. without Actisaf®？Sc 47) and the random effect of the trial. The meta-analysis showed a moderate heterogeneity for MY and ECM. The random effect meta-analysis showed an estimated mean difference +1.72 kg/d [95% confidence interval (CI): 1.01 to 2.44] and +2.45 kg/d (95% CI: 1.73 to 3.17) for MY and ECM respectively, in favour of Actisaf®Sc 47. The analysis of data without trials conducted under heat stress conditions showed positive effect of Actisaf® Sc 47. The random effect meta-analysis showed an estimated mean difference of +1.69 kg/d [95% CI: 1.24 to 2.14] and +2.92 kg/d (95% CI: 2.45 to 3.40) for MY and ECM respectively, in favour of Actisaf®？Sc 47. These observations provide strong evidence that this commercially available yeast probiotic can significantly improve milk performances of dairy cows under different conditions.
References
[1]
Chaucheyras-Durand, F. and Durand, H. (2009) Probiotics in Animal Nutrition and Health. Beneficial Microbes, 1, 3-9. https://doi.org/10.3920/BM2008.1002
[2]
Jouany, J-P. (2006) Optimizing Rumen Functions in the Close-up Transition Period and Early Lactation to Drive Dry Matter Intake and Energy Balance in Cows. Animal Reproduction Science, 96, 250-264. https://doi.org/10.1016/j.anireprosci.2006.08.005
[3]
Chaucheyras-Durand, F. and Fonty, G. (2002) Yeasts in Ruminant Nutrition. Expériences with Live Yeast Product. Kraftfutter, 85, 146-150.
[4]
Pedromo, M.C., Marsola, R.S., Favoreto, M.G., Adesogan, A., Staples, C.R. and Santos, J.E.P. (2019) Effects of Feeding Live Yeast at 2 Dosages on Performance and Feeding Behavior of Dairy Cows under Heat Stress. Journal of Dairy Science, 103, 325-339. https://doi.org/10.3168/jds.2019-17303
[5]
Bitencourt, L.L., Martins Silva, J.R., Lopez de Oliveira, B.M., Dias Junior, G.S., Lpoes, F., Siecola Junior, S., Zacaroni, O.F. and Pereira, N. (2001) Diet Digestibility and Performance of Dairy Cows Supplemented with Live Yeast. Scientia Agricola, 68, 301-307. https://doi.org/10.1590/S0103-90162011000300005
[6]
DeVries, T.J. and Chevaux, E. (2014) Modification of the Feeding Behavior of Dairy Cows through Live Yeast Supplementation. Journal of Dairy Science, 97, 6499-6510. https://doi.org/10.3168/jds.2014-8226
[7]
Dehghan-Banadaky, M., Ebrahimi, M., Motameny, R. and Heidari, S.R. (2013) Effects of Live Yeast Supplementation on Mid-Lactation Dairy Cow Performances, Milk Composition, Rumen Digestion and Plasma Metabolites during Hot Season. Journal of Applied Animal Research, 41, 137-142. https://doi.org/10.1080/09712119.2012.739085
[8]
Ferraretto, L.F., Shaver, R.D. and Bertics, S.J. (2012) Effect of Dietary Supplementation with Live-Cell Yeast at Two Dosages on Lactation Performance, Ruminal Fermentation, and Total-Tract Nutrient Digestibility in Dairy Cows. Journal of Dairy Science, 95, 4017-4028. https://doi.org/10.3168/jds.2011-5190
[9]
Kumprechtová, D., Illek, J., Juilen, C., Homolka, P., Jancik, F. and Auclair, E. (2019) Effect of Live Yeast (Saccharmyces cerevisiae) Supplementation on Rumen Fermentation and Metabolic Profile of Dairy Cows in Early Lactation. Journal of Animal Physiology and Animal Nutrition, 103, 447-455. https://doi.org/10.1111/jpn.13048
[10]
Salvati, G.G.S., Morais Junior, N.N., Melo, A.C.S., Vilela, R.R., Cardoso, F.F., Aronovish, M., Pereira, R.A.N. and Pereira, M.N. (2015) Response of Lactating Cows to Live Yeast Supplementation during Summer. Journal of Dairy Science, 98, 4062-4073. https://doi.org/10.3168/jds.2014-9215
[11]
Rossow, H.A., Riordan, T. and Riordan, A. (2018) Effects of Addition of a Live Yeast Product on Dairy Cattle Performance. Journal of Applied Animal Research, 46, 159-163. https://doi.org/10.1080/09712119.2017.1281810
[12]
Erasmus, L.J., Robinson, P.H., Ahmadi, A., Hinders, R. and Garrett, J.E. (2005) Influence of Prepartum and Postpartum Supplementation of a Yeast Culture and Monensin, or Both, on Ruminal Fermentation and Performance of Multiparous Dairy Cows. Animal Feed Science and Technology, 122, 219-239. https://doi.org/10.1016/j.anifeedsci.2005.03.004
[13]
Poppy, G.D., Rabiee, A.R., Lean, I.J., Sanchez, W.K., Dorton, K.L. and Morley, P.S. (2012) A Meta-Analysis of the Effects of Feeding Yeast Culture Produced by Anaerobic Fermentation of Saccharomyces cerevisiae on Milk Production of Lactating Dairy Cows. Journal of Dairy Science, 95, 6027-6041. https://doi.org/10.3168/jds.2012-5577
[14]
De Ondarza, M.B., Sniffen, C.J., Dussert, L., Chevaux, E., Sullivan, J. and Walker, N. (2010) CASE STUDY: Multiple-Study Analysis of the Effect of Live Yeast on Milk Yield, Milk Component Content and Yield, and Feed Efficiency. The Professional Animal Scientist, 26, 661-666. https://doi.org/10.15232/S1080-7446(15)30664-1
[15]
Abdelli, A., Besbaci, M., Hansali, S., Rahmani, B., Belabdi, I., Enjalbert, G. and Raboisson, D. (2022) Associantion between Yeast Product Feeding and Milk Production of Lactating Dairy Cows: Multilevel Meta-Analysis and Meta-Regression. Animal Feed Science and Technology, 285, Article ID: 115240. https://doi.org/10.1016/j.anifeedsci.2022.115240
[16]
Desnoyers, M., Giger-Reverdin, S., Bertin, G., Duveaux-Ponter, C. and Sauvant, D. (2008) Meta-Analysis of the Influence of Saccharomyces cerevisiae Supplementation on Ruminal Parameters and Milk Production of Ruminants. Journal of Dairy Science, 92, 1620-1632. https://doi.org/10.3168/jds.2008-1414
[17]
Tyrrell, H.F. and Reid, J.T. (1965) Prediction of the Energy Value of Cow’s Milk. Journal of Dairy Science, 48, 1215-1223. https://doi.org/10.3168/jds.S0022-0302(65)88430-2
[18]
Sauvant, D., Schmidely, P., Daudin, J.J. and St-Pierre, N.R. (2008) Meta-Analysis of Experimental Data in Animal Nutrition. Animal, 2, 1203-1214. https://doi.org/10.1017/S1751731108002280
[19]
Balduzzi, S., Rücker, G. and Schwarzer, G. (2019) How to Perform a Meta-Analysis with R: A Practical Tutorial. BMJ Mental Health, 22, 153-160. https://doi.org/10.1136/ebmental-2019-300117
[20]
Higgins, P.T.J. and Thompson, S.G. (2022) Quantifying Heterogeneity in a Meta-Analysis. Statistics in Medicine, 21, 1539-1558. https://doi.org/10.1002/sim.1186
[21]
Paul, J. and Barari, M. (2022) Meta-Analysis and Traditional Systematic Literature Reviews—What, Why, When, Where, and How? Psychology & Marketing, 39, 1099-1115. https://doi.org/10.1002/mar.21657
[22]
Begg, C.B. (1985) A Measure to Aid in the Interpretation of Published Clinical Trials. Statistics in Medecine, 4, 1-9. https://doi.org/10.1002/sim.4780040103
[23]
Rothstein, H., Sutton, A.J. and Borenstein, M. (2005) Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments. John Wiley and Sons Ltd., Chichester. https://doi.org/10.1002/0470870168
[24]
Wellman, N.G. and O’Connor, A.M. (2007) Meta-Analysis of Treatment of Cattle with Bovine Respiratory Disease with Tulathromycin. Journal of Veterinary Pharmacology and Therapeutics, 30, 234-241. https://doi.org/10.1111/j.1365-2885.2007.00846.x
[25]
Sniffen, C.J., Chaucheyras-Durand, F., Ondarza, M.B. and Donaldson, G. (2004) Predicting the Impact of Live Yeast Strain on Rumen Kinetics and Ration Formulation. Proceedings of the South West Nutrition and Managment Coference, Phoenix, 24-25 February 2004, 53-59.
[26]
Mosoni, P., Chaucheyras-Durand, F., Bera-Maillet, C. and Forano, E. (2007) Quantification by Real-Time PCR of Cellulolytic Bacteria in the Rumen of Sheep after Supplementation of a Forage Diet with Readily Fermentable Carbohydrates: Effect of Yeast Additive. Journal of Applied Microbiology, 103, 2676-2685. https://doi.org/10.1111/j.1365-2672.2007.03517.x
[27]
Nocek, J.E. and Kautz, W.P. (2006) Direct-Fed Microbial Supplementation on Ruminal Digestion, Health, and Performance of Pre- and Postpartum Dairy Cattle. Journal of Dairy Science, 89, 260-266. https://doi.org/10.3168/jds.S0022-0302(06)72090-2
[28]
Marden, J.P., Juilen, C., Monteils, V., Auclair, E., Moncoulon, R. and Bayourthe, C. (2008) How Does Live Yeast Differ from Sodium Bicaronate to Stabilize Ruminal pH in High-Yielding Dairy Cows? Journal of Dairy Science, 91, 3528-3535. https://doi.org/10.3168/jds.2007-0889
[29]
Tristant, D. and Moran, C.A. (2015) The Efficacy of Feeding a Live Probiotic Yeast, Yea-Sacc, on the Performance of Lactating Dairy Cows. Journal of Applied Animal Nutrition, 3, 1-6. https://doi.org/10.1017/jan.2015.10
[30]
Tricarico, J., Harrison, G. and Johnston, J. (2006) Modeling Yea-Sacc®1026 Effect on Ruminal Function and Performance in Lactating Dairy Cattle within the Framework of the CPM-Dairy Ration Analyzer. Nutritional Biotechnology in the Feed and Food Industries, Alltech’s 22nd Annual Symposium (Poster Session), Lexington.
[31]
Moallem, U., Lehrer, H., Livshitz, L., Zachut, M. and Yakoby, S. (2009) The Effects of Live Yeast Supplementation to Dairy Cows during the Hot Season on Production, Feed Efficiency, and Digestibility. Journal of Dairy Science, 92, 343-351. https://doi.org/10.3168/jds.2007-0839
[32]
Oh, J., Harper, M., Melgar, A., Paulus Compart, D.M. and Hristov, A.N. (2019) Effects of Saccharomyces cerevisiae-Based Direct-Fed Microbial and Exogenous Enzyme Products on Enteric Methane Emission and Productivity in Lactating Dairy Cows. Journal of Dairy Science, 102, 6065-6075. https://doi.org/10.3168/jds.2018-15753
[33]
Blottiere, H.M., Buecher, B., Galmiche, J.-P. and Gherbut, C. (2003) Molecular Analysis of the Effect of Short-Chain Fatty Acids on Intestinal Cell Proliferation. Proceedings of the Nutrition Society, 62, 101-106. https://doi.org/10.1079/PNS2002215
[34]
Sakata, T. (2004) Effects of Short-Chain Fatty Acids on the Proliferation of Gut Epithelial Cells in Vivo. In: Cummings, T.S., Ohn H. and Rombeau, J.L., Eds., Effects of Short-Chain Fatty Acids on the Proliferation of Gut Epithelial Cells in Vivo, Cambridge University Press, Cambridge.
[35]
Bannink, A., Gerrits, W.J.J., France, J. and Dijkstra, J. (2012) Variation in Rumen Fermentation and the Rumen Wall during the Transition Period in Dairy Cows. Animal Feed Science and Technology, 172, 80-94. https://doi.org/10.1016/j.anifeedsci.2011.12.010
[36]
Julien, C., Marden, J.P., Auclair, E., Moncoulon, R., Cauquil, L., Peyraud, J.L. and Bayourthe, C. (2015) Interaction between Live Yeast and Dietary Rumen Degradable Protein Level: Effects on Diet Utilization in Early-Lactating Dairy Cows. Agricultural Sciences, 6, 1-13. https://doi.org/10.4236/as.2015.61001
[37]
Kaufman, J.D., Kassube, K.R. and Rius, A.G. (2017) Lowering Rumen-Degradable Protein Maintained Energy-Corrected Milk Yield and Improved Nitrogen-Use Efficiency in Multiparous Lactating Dairy Cows Exposed to Heat Stress. Journal of Dairy Science, 100, 8132-8145. https://doi.org/10.3168/jds.2017-13026
