The application of vibrational spectroscopy in the
pharmaceutical industry is widely investigated, from the quality assurance of
the product during the production process control to the final products’
quality control and the authentication of products on the markets. This study
focuses on non-contact and noninvasive detection and identification of pain-relievers
at 1-5 meters standoff distances. The specimens analyzed include standard
laboratory-grade active ingredients and
commercially available pain relievers in powder, solid and liquid forms. All
the remote measurements captured revealed the Raman signatures of the
specimens, with varying peak intensities. To correlate the band intensities
captured with the standoff distances between the laser source and the
specimens, the intensity ratios of the two prominent peaks of the laboratory
grade reference active ingredient (1607 and 1319 cm-1) normalized
with 1319 cm-1 are used. The results of the study suggest the
viability of standoff Raman spectroscopy for routine monitoring and
identification of pharma-ceuticals, including counterfeit pain
relievers.
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