Objective: The aim of this study was to compare the olfactory function between hairdressers exposed to formaldehyde and unexposed controls, as exposure to toxic agents is a potential cause of olfactory disorders in humans. Hairdressing professionals frequently encounter formaldehyde, a component found in hair products that are known to have various toxic effects on the human body, including alterations in the sense of smell. Methods: A total of 32 hairdressing volunteers exposed to formaldehyde and 32 non-exposed volunteers matched for age, sex, education and smoking status underwent the University of Pennsylvania Smell Identification Test (UPSIT®). Results: The findings demonstrated a decrease in UPSIT® olfactory test scores and a higher degree of olfactory loss among hairdressers exposed to formaldehyde (mean UPSIT® scores: 30.6 vs 35.1, p < 0.01) compared to the unexposed controls. Conclusion: Occupational exposure of hairdressers to formaldehyde is associated with diminished olfactory function. Education approach and promotion of personal protective equipment usage should be encouraged.
References
[1]
Croy, I., Nordin, S. and Hummel, T. (2014) Olfactory Disorders and Quality of Life—An Updated Review. Chemical Senses, 39, 185-194. https://doi.org/10.1093/chemse/bjt072
[2]
Boesveldt, S., Postma, E.M., Boak, D., et al. (2017) Anosmia—A Clinical Review [Published Correction Appears in Chemical Senses, 2017 Sep 1; 42(7): 607]. Chemical Senses, 42, 513-523. https://doi.org/10.1093/chemse/bjx025
[3]
Nordin, S. and Brämerson, A. (2008) Complaints of Olfactory Disorders: Epidemiology, Assessment and Clinical Implications. Current Opinion in Allergy and Clinical Immunology, 8, 10-15. https://doi.org/10.1097/ACI.0b013e3282f3f473
[4]
Upadhyay, U.D. and Holbrook, E.H. (2004) Olfactory Loss as a Result of Toxic Exposure. Otolaryngologic Clinics of North America, 37, 1185-1207. https://doi.org/10.1016/j.otc.2004.05.003
[5]
Bregnhøj, A., Søsted, H., Menné, T. and Johansen, J.D. (2011) Exposures and Reactions to Allergens among Hairdressing Apprentices and Matched Controls. Contact Dermatitis, 64, 85-89. https://doi.org/10.1111/j.1600-0536.2010.01843.x
[6]
lorenzini, S. (2012) Adverse Effects of Formaldehyde Exposure in Hairdressers. Thesis (Doctorate), Federal University of Rio Grande do Sul, Faculty of Medicine, Graduate Program in Pulmonological Sciences, Porto Alegre.
[7]
Naya, M. and Nakanishi, J. (2005) Risk Assessment of Formaldehyde for the General Population in Japan. Regulatory Toxicology and Pharmacology, 43, 232-248. https://doi.org/10.1016/j.yrtph.2005.08.002
[8]
Zhang, Q., Yan, W., Bai, Y., Zhu, Y. and Ma, J. (2014) Repeated Formaldehyde Inhalation Impaired Olfactory Function and Changed SNAP25 Proteins in Olfactory Bulb. International Journal of Occupational and Environmental Health, 20, 308-312. https://doi.org/10.1179/2049396714Y.0000000079
[9]
Apfelbach, R. and Weiler, E. (1991) Sensitivity to Odors in Wistar Rats Is Reduced after Low-Level Formaldehyde-Gas Exposure. Naturwissenschaften, 78, 221-223. https://doi.org/10.1007/BF01136085
[10]
Fornazieri, M.A., dos Santos, C.A., Bezerra, T.F., Pinna Fde, R., Voegels, R.L. and Doty, R.L. (2015) Development of Normative Data for the Brazilian Adaptation of the University of Pennsylvania Smell Identification Test. Chemical Senses, 40, 141-149. https://doi.org/10.1093/chemse/bju068
[11]
Fokkens, W.J., Lund, V.J., Hopkins, C., et al. (2020) European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology, 58, 1-464.
[12]
Fornazieri, M.A., Pinna Fde, R., Bezerra, T.F., Antunes, M.B. and Voegels, R.L. (2010) Applicability of the University of Pennsylvania Smell Identification Test (SIT) in Brazilians: Pilot Study. Brazilian Journal of Otorhinolaryngology, 76, 695-699. https://doi.org/10.1590/S1808-86942010000600004
[13]
Zhan, W. (2003) Formaldehyde to Glyoxylic Acid. In: Ullmann’s Encyclopedia of Industrial Chemistry Elvers, v. 15. Wiley-VCH, Hoboken, 700 p.
[14]
Werner, S. and Nies, E. (2018) Olfactory Dysfunction Revisited: A Reappraisal of Work-Related Olfactory Dysfunction Caused by Chemicals. Journal of Occupational Medicine and Toxicology, 13, Article No. 28. https://doi.org/10.1186/s12995-018-0209-6
[15]
Gobba, F. (2006) Olfactory Toxicity: Long-Term Effects of Occupational Exposures. The International Archives of Occupational and Environmental Health, 79, 322-331. https://doi.org/10.1007/s00420-005-0043-x
[16]
Spealman, C.R. (1954) Odors, Odorants, and Deodorants in Aviation. Annals of the New York Academy of Sciences, 58, 40-43. https://doi.org/10.1111/j.1749-6632.1954.tb54839.x
[17]
Kilburn, K.H., Seidman, B.C. and Warshaw, R. (1985) Neurobehavioral and Respiratory Symptoms of Formaldehyde and Xylene Exposure in Histology Technicians. Archives of Environmental Health, 40, 229-233. https://doi.org/10.1080/00039896.1985.10545924