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结核分枝杆菌特点及诊断新进展
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Abstract:
由于全球结核病发病人数、耐药率、死亡人数近年来再次出现上升趋势，而病原学诊断阳性率较低，使得加强对结核分枝杆菌的感染诊断成为必要。结核分枝杆菌感染后，机体通过细胞免疫及体液免疫反应应答，主要为细胞免疫，结核分枝杆菌细胞壁上的一些高特异性免疫学相关物质具有诊断潜力。近年来，不断有专家学者对结核分枝杆菌的感染诊断提出了新的研究方向，包括病原学、分子生物学、免疫学诊断试验，这提高了临床诊断准确率与及时性。本文就结核分枝杆菌特点及感染诊断新进展作相应的综述。
The global trend of increasing number of TB incidence, drug resistance and deaths again in recent years and the low rate of positive pathogenic diagnosis make it necessary to enhance the diagnosis of Mycobacterium tuberculosis infection. After Mycobacterium tuberculosis infection, the organism responds through cellular and humoral immune responses, mainly cellular immunity, and some highly specific immunologically relevant substances produced and released during this process have diagnostic potential. In recent years, experts and scholars have continuously proposed new research directions for the diagnosis of Mycobacterium tuberculosis infection, including pathogene-sis, molecular biology, and immunological diagnostic tests, which have improved the accuracy and timeliness of clinical diagnosis. Therefore, this paper provides a review based on the new advances in the diagnosis of Mycobacterium tuberculosis infection.
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