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中药单体在子宫内膜癌中抗肿瘤机制的研究进展
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Abstract:
子宫内膜癌凭借复杂的发病机制及不良的预后特征，成为严重危害女性身心健康的恶性肿瘤。随着科技的进步，针对子宫内膜癌的诊疗计划也在不断地被深入研讨，其中，中药单体在治疗角度方面表现出积极的抗肿瘤活性，主要依靠影响信号通路、炎性物质、细胞凋亡、侵袭和转移，甚至可作为辅助治疗的增敏剂发挥抑癌作用。回顾文献，总结整合了中药单体作用于子宫内膜癌的相关文献，并进行综述。以望为今后子宫内膜癌的诊治方案带来新思路。
Endometrial cancer has become a malignant tumor that seriously endangers women’s physical and mental health due to its complex pathogenesis and poor prognosis. With the advancement of sci-ence and technology, the diagnosis and treatment plan for endometrial cancer is also constantly being studied in depth, among which, traditional Chinese medicine monomers show a positive an-ti-tumor activity in the treatment perspective, mainly relying on the influence of signaling pathways, inflammatory substances, apoptosis, invasion and metastasis, and even can be used as a sensitizer for adjuvant therapy to play a tumor inhibitory effect. This paper reviews the literature, summariz-es and integrates the important mechanisms of traditional Chinese medicine active substances act-ing on endometrial cancer, and hopes to bring new ideas for the diagnosis and treatment of endo-metrial cancer in the future.
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