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血栓弹力图联合凝血因子监测对高血压脑出血患者的预后判断价值
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Abstract:
高血压脑出血是我国临床常见病，因其高致残率、高致死率引起人们的广泛关注，早期关注血栓弹力图以及凝血因子可以监测患者病情变化，避免二次出血。本文从部分血栓弹力图参数、凝血因子的特点以及脑出血后的变化及意义进行阐述，以期能够为高血压脑出血的病情控制、预后判断评估等方面提供参考。
Hypertensive cerebral hemorrhage is a common clinical disease in my country. It has attracted widespread attention because of its high disability rate and high mortality rate. Early attention to thrombelastography and coagulation factors can monitor the changes of patients’ condition and avoid secondary bleeding. In this paper, the characteristics of some thrombelastography parame-ters and coagulation factors, as well as the changes and significance after hemorrhage are described, in order to provide reference for the control of hypertensive cerebral hemorrhage and the evalua-tion of prognosis.
| [1] | Poon, M.T., Fonville, A.F. and Al-Shahi Salman, R. (2014) Long-Term Prognosis after Intracerebral Haemorrhage: Systematic Review and Meta-Analysis. Journal of Neurology, Neurosurgery, and Psychiatry, 85, 660-667.
https://doi.org/10.1136/jnnp-2013-306476 |
| [2] | Hostettler, I.C., Seiffge, D.J. and Werring, D.J. (2019) Intracerebral Hemorrhage: An Update on Diagnosis and Treatment. Expert Review of Neurotherapeutics, 19, 679-694. https://doi.org/10.1080/14737175.2019.1623671 |
| [3] | 唐志清, 梁新强. 高血压脑出血发病机制及外科治疗研究进展[J]. 蛇志, 2020, 32(3): 369-371. |
| [4] | Pavoni, V., Gianesello, L., Conti, D., et al. (2022) “In Less than No Time”: Feasibility of Rotational Thromboelastometry to Detect Anticoagulant Drugs Activity and to Guide Reversal Therapy. Journal of Clinical Medicine Research, 11, Article 1407. https://doi.org/10.3390/jcm11051407 |
| [5] | Schmidt, A.E., Israel, A.K. and Refaai, M.A. (2019) The Utility of Thromboelastography to Guide Blood Product Transfusion. American Journal of Clinical Pathology, 152, 407-422. https://doi.org/10.1093/ajcp/aqz074 |
| [6] | Ramiz, S., Hartmann, J., Young, G., Escobar, M.A. and Chitlur, M. (2019) Clinical Utility of Viscoelastic Testing (TEG and ROTEM Analyzers) in the Management of Old and New Therapies for Hemophilia. American Journal of Hematology, 94, 249-256. https://doi.org/10.1002/ajh.25319 |
| [7] | Agarwal, S. and Abdelmotieleb, M. (2020) Viscoelastic Testing in Cardiac Surgery. Transfusion, 60, S52-S60.
https://doi.org/10.1111/trf.16075 |
| [8] | Walsh, M., Moore, E.E., Moore, H.B., et al. (2021) Whole Blood, Fixed Ra-tio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review. Journal of Clinical Medicine, 10, Article 320. https://doi.org/10.3390/jcm10020320 |
| [9] | Yoon, U., Bartoszko, J., Bezinover, D., et al. (2022) Intraoperative Transfusion Management, Antifibrinolytic Therapy, Coagulation Monitoring and the Impact on Short-Term Outcomes after Liver Transplantation—A Systematic Review of the Literature and Expert Panel Recommendations. Clinical Trans-plantation, 36, e14637.
https://doi.org/10.1111/ctr.14637 |
| [10] | Amgalan, A., Allen, T., Othman, M. and Ahmadzia, H.K. (2020) Systematic Review of Viscoelastic Testing (TEG/ROTEM) in Obstetrics and Recommendations from the Women’s SSC of the ISTH. Journal of Thrombosis and Haemostasis, 18, 1813-1838. https://doi.org/10.1111/jth.14882 |
| [11] | Katsaras, G., Sokou, R., Tsantes, A.G., et al. (2021) The Use of Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) in Neonates: A Systematic Review. European Journal of Pediatrics, 180, 3455-3470.
https://doi.org/10.1007/s00431-021-04154-4 |
| [12] | Burton, A.G. and Jandrey, K.E. (2020) Use of Thromboelas-tography in Clinical Practice. Veterinary Clinics of North America: Small Animal Practice, 50, 1397-1409. https://doi.org/10.1016/j.cvsm.2020.08.001 |
| [13] | Subramanian, M., Kaplan, L.J. and Cannon, J.W. (2019) Throm-boelastography-Guided Resuscitation of the Trauma Patient. JAMA Surgery, 154, 1152-1153. https://doi.org/10.1001/jamasurg.2019.3136 |
| [14] | Othman, M. and Kaur, H. (2017) Thromboelastography (TEG). In: Favaloro, E. and Lippi, G., Eds., Hemostasis and Thrombosis, Humana Press, New York, 533-543. https://doi.org/10.1007/978-1-4939-7196-1_39 |
| [15] | 陈燕青, 张奇, 李婷婷, 等. 凝血功能指标联合血栓弹力图参数对高血压脑出血预后的评估[J]. 中国卫生检验杂志, 2021, 31(14): 1737-1740, 1769. |
| [16] | 刘宗宝, 乾栋梁, 蒋陈君, 等. 急性脑出血和脑梗死患者血栓弹力图的比较[J]. 医药卫生科技, 2020, 19(7): 69-71. |
| [17] | Liu, Z.B., Chai, E., Chen, H.C., Huo, H.Z. and Tian, F. (2018) Comparison of Thrombelastography (TEG) in Patients with Acute Cerebral Hemorrhage and Cerebral Infarction. Medical Science Monitor, 24, 6466-6471.
https://doi.org/10.12659/MSM.910121 |
| [18] | Vilar, R., Fish, R.J., Casini, A. and Neerman-Arbez, M. (2020) Fibrin (Ogen) in Human Disease: Both Friend and Foe. Haematologica, 105, 284-296. https://doi.org/10.3324/haematol.2019.236901 |
| [19] | Luyendyk, J.P., Schoenecker, J.G. and Flick, M.J. (2018) The Multifaceted Role of Fibrinogen in Tissue Injury and Inflammation. The American Society of Hematology, 133, 511-520. https://doi.org/10.1182/blood-2018-07-818211 |
| [20] | 史丹丹, 汪国爱. 血清Fib与pro-BNP联合测定在老年高血压脑出血后脑水肿患者神经功能损伤中的预测价值[J]. 浙江中西医结合杂志, 2018, 28(4): 290-292. |
| [21] | Van Den Herik, E.G., Cheung, E.Y., De Lau, L.M., et al. (2012) Fibrinogen γ’ Levels in Patients with Intracerebral Hemor-rhage. Thrombosis Research, 129, 807-809. https://doi.org/10.1016/j.thromres.2011.08.017 |
| [22] | Mcbride, D., Tang, J. and Zhang, J.H. (2017) Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage. Current Drug Targets, 18, 1349-1357.
https://doi.org/10.2174/1389450117666151209123857 |
| [23] | Petersen, M.A., Ryu, J.K. and Akassoglou, K. (2018) Fibrinogen in Neurological Diseases: Mechanisms, Imaging and Therapeutics. Nature Reviews Neuroscience, 19, 283-301. https://doi.org/10.1038/nrn.2018.13 |
| [24] | Specogna, A.V., Turin, T.C., Patten, S.B. and Hill, M.D. (2014) Factors Associated with Early Deterioration after Spontaneous Intracerebral Hemorrhage: A Systematic Review and Me-ta-Analysis. PLOS ONE, 9, e96743.
https://doi.org/10.1371/journal.pone.0096743 |
| [25] | 沈萍萍, 夏圣. 不同疾病中血栓弹力图与凝血4项对凝血功能的一致性分析[J]. 中国现代医学杂志, 2019, 29(9): 79-84. |
| [26] | Yao, J., Bai, T., Yang, B. and Sun, L.Z. (2021) The Diagnostic Value of D-Dimer in Acute Aortic Dissection: A Meta-analysis. Journal of Cardiothoracic Surgery, 16, Article No. 343. https://doi.org/10.1186/s13019-021-01726-1 |
| [27] | Franczyk, B., Gluba-Brzózka, A., ？awiński, J., Rysz-Górzyńska, M. and Rysz, J. (2021) Metabolomic Profile in Venous Thromboembolism (VTE). Metabolites, 11, Article 495. https://doi.org/10.3390/metabo11080495 |
| [28] | Duffett, L., Castellucci, L.A. and Forgie, M.A. (2020) Pulmonary Embolism: Update on Management and Controversies. The BMJ, 370, m2177. https://doi.org/10.1136/bmj.m2177 |
| [29] | Hahne, K., Lebiedz, P. and Breuckmann, F. (2014) Impact of D-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects besides the Widely Known. Clinical Medicine Insights: Cardiology, 8s2, 1-4.
https://doi.org/10.4137/CMC.S15948 |
| [30] | Yamada, S. and Asakura, H. (2022) Therapeutic Strategies for Dissem-inated Intravascular Coagulation Associated with Aortic Aneurysm. International Journal of Molecular Sciences, 23, Ar-ticle 1296.
https://doi.org/10.3390/ijms23031296 |
| [31] | Paulin, B.K., Cedric, K.K., Hui, Y.D. and Tamomh, A.G. (2019) As-sessment of Cardiac Biomarkers (Troponin, B-Type Natriuretic Peptide, and D-Dimer) in Patients with Non-Valvular Atrial Fibrillation and Stroke. International Journal of Health Sciences, 13, 3-12. |
| [32] | Zhou, Q., Zhang, D., Chen, X., et al. (2021) Plasma D-Dimer Predicts Poor Outcome and Mortality after Spontaneous Intracerebral Hemorrhage. Brain and Behavior, 11, 462-468. https://doi.org/10.1002/brb3.1946 |
| [33] | 董蔚蔚, 李新星, 王文卿, 等. 血清D-二聚体水平与急性脑出血疾病严重程度及早期预后的关系[J]. 临床神经病学杂志, 2018, 31(3): 219-221. |
| [34] | Anderson, T.N., Farrell, D.H. and Rowell, S.E. (2021) Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations. Seminars in Thrombosis and Hemostasis, 47, 527-537.
https://doi.org/10.1055/s-0041-1722970 |
| [35] | 吴鲲鹏, 韦程, 何同. D？二聚体联合血栓弹力图对急性脑出血患者出血量及死亡风险的评估[J]. 分子诊断与治疗杂志, 2020, 12(11): 1461-1465. |
| [36] | 杨兵. 凝血酶原时间和活化部分凝血活酶时间测定的应用研究[J]. 血栓与止血学, 2020, 26(1): 102-103. |
| [37] | 易康平. 凝血酶原时间和活化部分凝血活酶时间测定的临床意义[J]. 基层医学论坛, 2019, 23(31): 4527-4528. |
| [38] | 吴婵姬, 黄仕雄. 脑出血与脑梗死患者D-二聚体和凝血功能指标的变化研究[J]. 中国实用神经疾病杂志, 2018, 21(4): 399-401. |
| [39] | 吴敏华, 蔡葵, 黎裕元. 血栓弹力图的反应时间与凝血四项中APTT的相关关系[J]. 广东医学, 2019(s1): 325-326, 329. |
| [40] | Dorgalaleh, A., Favaloro, E.J., Bahraini, M. and Rad, F. (2021) Standardization of Prothrombin Time/International Normalized Ratio (PT/INR). International Journal of Laboratory Hematology, 43, 21-28.
https://doi.org/10.1111/ijlh.13349 |
| [41] | Bronic, A., Coen Herak, D., Margetic, S. and Mili？, M. (2019) Croatian Society of Medical Biochemistry and Laboratory Medicine: National Recommendations for Blood Collection, Processing, Performance and Reporting of Results for Coagulation Screening Assays Prothrombin Time, Activated Partial Thrombo-plastin Time, Thrombin Time, Fibrinogen and D-Dimer. Biochemia Medica, 29, Article ID: 020503. https://doi.org/10.11613/BM.2019.020503 |
| [42] | Wang, S., Ma, T., Wang, L., et al. (2017) Effect of Acupuncture on Cerebrovascular Reserve in Patients with Acute Cerebral Infarction: Protocol for a Randomized Controlled Pilot Study. Trials, 18, Article No. 292.
https://doi.org/10.1186/s13063-017-2013-5 |
| [43] | Lauridsen, S.V., Hvas, A.M., Sandgaard, E., et al. (2018) Coagu-lation Profile after Spontaneous Intracerebral Hemorrhage: A Cohort Study. Journal of Stroke and Cerebrovascular Diseases, 27, 2951-2961.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.022 |
| [44] | 鲍洁, 王青. 高血压脑出血患者凝血功能与预后探讨[J]. 血栓与止血学, 2019, 25(5): 780-781, 784. |
| [45] | 李春艳, 何安华, 储节华. 血栓弹力图与常规凝血四项评价临床患者凝血功能的对比分析[J]. 世界最新医学信息文摘, 2018(60): 166. |
