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细胞衰老标志物与衰老相关疾病的关系探讨
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Abstract:
公共卫生和医学的不断进步推动着人类预期寿命的增长，目前老龄化持续加剧已成为我国乃至世界社会发展中不可逆转的趋势，据国家统计局最新数据显示我国65岁及以上人口20,056万人，占全国人口的14.2%，我国已进入深度老龄化阶段。神经退行性疾病、心脑血管疾病、癌症等的发生发展均与机体衰老密切相关，实现健康老龄化延缓衰老相关疾病的发生显得至关重要。细胞衰老是机体衰老和死亡的基础，因此，我们探究细胞衰老潜在标志物细胞周期抑制蛋白表达、端粒损耗、DNA损伤、衰老相关-β-半乳糖苷酶(SA-β-Gal)、衰老相关分泌表型(SASP)、核纤层蛋白B1 (Lamin B1)、衰老相关异色病灶(SAHF)、自噬与衰老相关疾病的关系，为后续探索更有价值的标志物来预测、延缓衰老相关疾病进展，实现健康老龄化奠基。
The continuous progress of public health and medicine has promoted the growth of human life ex-pectancy, and aging has become an irreversible trend in the development of our country and even the world society. According to the latest data from the National Bureau of Statistics, China’s popu-lation of 65 years old and above is 2005.6 million people, which accounts for 14.2% of the national population, and our country has entered into the stage of deep aging. The development of neuro-degenerative diseases, cardiovascular and cerebrovascular diseases, cancer and others is closely related to the aging of the organism, to achieve healthy aging to slow down the occurrence of dis-eases related to aging seems to be crucial. Cellular senescence is the basis of aging and death, therefore, we explore the relationship between potential markers of cellular senescence, such as cell cycle inhibitory protein expression, telomere attrition, DNA damage, senescence-associated-β- galactosidase (SA-β-Gal), senescence-associated secretory phenotype (SASP), nuclear fibrillar lam-inin B1 (Lamin B1), senescence-associated heterochromatic foci (SAHF) and autophagy, and ag-ing-related diseases, to provide a basis for the subsequent exploration of the development of healthy aging and slowing down of the development of aging-related diseases, laying the foundation for subsequent exploration of more valuable markers to predict and delay the progression of ag-ing-related diseases and achieve healthy aging.
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