不同剂量燕麦β-葡聚糖对老年大鼠空腹血糖和糖耐量的影响
Effects of Different Doses of Oats β-Glucan on Fasting Blood Glucose and Glucose Tolerance in Aged Rats

目的：研究不同剂量燕麦c-葡聚糖(BG)对老年Sprague Dawley大鼠空腹血糖和糖耐量的影响。方法：正常20月龄大鼠24只随机分为4组：高脂膳食组、高脂膳食 + 2% BG组、高脂膳食 + 5% BG组和高脂膳食 + 10% BG组，记录大鼠采食量和体重。饲喂3周后，测定空腹血糖及口服糖耐量。结果：高脂膳食添加2% BG延缓体重增加和降低血糖的效果最佳，高脂膳食添加5% BG可能促进体重增加。高脂膳食添加10% BG组餐后血糖波动幅度更小。结论：燕麦β-葡聚糖在调节老年大鼠血糖方面有特征性剂量效应，老年人摄入燕麦β-葡聚糖时需注意剂量。
Objective: To study the effects of different doses of oats β-glucan (BG) on fasting blood glucose and glucose tolerance in aged rats. Method: 24 normal 20 month old rats were randomly divided into 4 groups: high fat diet group, high fat diet + 2% BG group, high fat diet + 5% BG group, and high fat diet + 10% BG group. The food intake and weight of the rats were recorded. After feeding for 3 weeks, fasting blood glucose and oral glucose tolerance were measured. Result: Adding 2% BG to a high-fat diet has the best effect on delaying weight gain and lowering blood glucose. Adding 5% BG to a high-fat diet may promote weight gain. The post prandial blood glucose fluctuation was smaller in the high fat diet supplemented with 10% BG group. Conclusion: Oats β-glucan has a characteristic dose effect in regulating blood glucose in elderly rats. The elderly people should pay attention to the dosage duringintake of oats β-glucan.？