Every year, millions of people incur damage to sensory receptors that interact with the external environment. Two areas of concern are hearing loss (affecting around 430 million) and burns (affecting 11 million annually). Current treatments for burns involve skin grafts, which are expensive and prone to rejection by the body. Current treatments for hearing loss involve implants and hearing aids, which have limited sensitivity, need batteries and charging, are expensive, and are prone to infection. Thus, there is a need for a self-powered, flexible, biocompatible, antibacterial, and inexpensive solution that can respond to stimuli at a rate comparable to tissue. Piezoelectric materials convert mechanical energy into electricity, thus replicating touch and hearing by simulating nerve signals. In this study, piezoelectric membranes with varying ratios of polyvinylidene fluoride (PVDF) and zinc oxide (ZnO) were fabricated using electrospinning. These membranes were characterized with scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), stress-strain analysis, and piezoresponse testing. Results showed that increasing the amount of PVDF made the membrane more flexible but reduced its piezoelectric potential (decrease in PVDF β-phase). Increasing the amount of ZnO significantly increased piezoelectric potential (increase in PVDF β-phase) but degraded the flexibility and usability of the membrane. Therefore, a 1:1 w/w ratio of PVDF to ZnO is the optimum ratio for balancing both piezoelectric potential and flexibility. These results support the hypothesis that composites of PVDF and ZnO can help realize self-powered hearing rehab devices and wearable electronic skin.
References
[1]
World Health Organization (2018) Burns. https://www.who.int/news-room/fact-sheets/detail/burns
[2]
McDermott, K.W., Weiss, A.J. and Elixhauser, A. (2017) Burn-Related Hospital Inpatient Stays and Emergency Department Visits, 2013. Agency for Healthcare Research and Quality (US), Rockville. https://europepmc.org/article/nbk/nbk409513
[3]
Dixit, S., Baganizi, D.R., Sahu, R., Dosunmu, E., Chaudhari, A., Vig, K., Pillai, S.R., Singh, S.R. and Dennis, V.A. (2017) Immunological Challenges Associated with Artificial Skin Grafts: Available Solutions and Stem Cells in Future Design of Synthetic Skin. Journal of Biological Engineering, 11, Article No. 49. https://doi.org/10.1186/s13036-017-0089-9
[4]
UVA Health (2022) Skin Graft. https://uvahealth.com/services/plastic-surgery/skin-graft
[5]
World Health Organization (2021) Deafness and Hearing Loss. https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss
[6]
Kampsen Hearing (2020) What Are the Pros and Cons of Cochlear Implants. https://kampsenhearing.com/what-are-the-pros-and-cons-of-cochlear-implants
[7]
İlik, B., Koyuncuoğlu, A., Şardan-Sukas, Ö. and Külah, H. (2018) Thin Film Piezoelectric Acoustic Transducer for Fully Implantable Cochlear Implants. Sensors and Actuators A: Physical, 280, 38-46. https://doi.org/10.1016/j.sna.2018.07.020
[8]
Lin, W., Wang, B., Peng, G., Shan, Y., Hu, H. and Yang, Z. (2021) Skin-Inspired Piezoelectric Tactile Sensor Array with Crosstalk-Free Row + Column Electrodes for Spatiotemporally Distinguishing Diverse Stimuli. Advanced. Science, 8, Article ID: 2002817. https://doi.org/10.1002/advs.202002817
[9]
Kim, D.W., Kim, H., Hwang, G.-T., Cho, S.B., Jeon, S.H., Kim, H.W., Jeong, C.K., Chun, S. and Pang, C. (2022) Conformably Skin-Adherent Piezoelectric Patch with Bioinspired Hierarchically Arrayed Microsuckers Enables Physical Energy Amplification. ACS Energy Letters, 7, 1820-1827. https://doi.org/10.1021/acsenergylett.2c00259
[10]
Stöver, T. and Lenarz, T. (2011) Biomaterials in Cochlear Implants. GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery, 8, Doc10.
Zaszczynska, A., Sajkiewicz, P. and Gradys, A. (2020) Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering. Polymers, 12, Article 161. https://doi.org/10.3390/polym12010161
[13]
Ruan, L., Yao, X., Chang, Y., Zhou, L., Qin, G. and Zhang, X. (2018) Properties and Applications of the β Phase Poly(vinylidene fluoride). Polymers, 10, Article 228. https://doi.org/10.3390/polym10030228
[14]
Taleb, S., Badillo-Avila, M.A. and Acuautla, M. (2021) Enhanced Performance of Flexible Piezoelectric PVDF Sensors by Ultrasonic Spray Coating Method. 2021 IEEE International Symposium on Applications of Ferroelectrics (ISAF), Sydney, 16-21 May 2021, 1-4. https://doi.org/10.1109/ISAF51943.2021.9477342
[15]
Sigma-Aldrich (2021) Safety Data Sheet Revision Date 01/21/2021 Version 6. https://www.sigmaaldrich.com/US/en/sds/ALDRICH/182702
[16]
Mahalakshmi, S., Hema, N. and Vijaya, P.P. (2020) In Vitro Biocompatibility and Antimicrobial Activities of Zinc Oxide Nanoparticles (ZnO NPs) Prepared by Chemical and Green Synthetic Route—A Comparative Study. BioNanoScience, 10, 112-121. https://doi.org/10.1007/s12668-019-00698-w
[17]
Srikanth, K.S., Wazeer, A., Mathiyalagan, P., Vidya, S., Rajput, K. and Kushwaha, H.S. (2021) 25—Piezoelectric Properties of Zno. In: Awasthi, K., Ed., Nanostructured Zinc Oxide: Synthesis, Properties and Applications, Elsevier, Amsterdam, 717-736. https://doi.org/10.1016/B978-0-12-818900-9.00024-3
[18]
Mendes, C., Dilarri, G., Forsan, C.N., De Moraes Ruy Sapata, V., Lopes, P.S., De Moraes, P.B., Montagnolli, R.N., Ferreira, H.B. and Bidoia, E.D. (2022) Antibacterial Action and Target Mechanisms of Zinc Oxide Nanoparticles against Bacterial Pathogens. Scientific Reports, 12, Article No. 2658. https://doi.org/10.1038/s41598-022-06657-y
[19]
Wille, A., Mishra, Y.K., Gedamu, D., Paulowicz, I., Jin, X. and Adelung, R. (2011) Zinc Oxide Micro- and Nanostructures as Multifunctional Materials. SPIE—The International Society of Optics and Photonics Search. https://doi.org/10.1117/2.1201111.003944 https://spie.org/news/3944-zinc-oxide-micro--and-nanostructures-as-multifunctional-materials?SSO=1
[20]
Bhadwal, N., Mrad, R.B. and Behdinan, K. (2023) Review of Zinc Oxide Piezoelectric Nanogenerators: Piezoelectric Properties, Composite Structures and Power Output. Sensors, 23, Article 3859. https://doi.org/10.3390/s23083859
[21]
Meringolo, C., Mastropietro, T.F., Poerio, T., Fontananova, E., De Filpo, G., Curcio, E. and Di Profio, G. (2018) Tailoring PVDF Membranes Surface Topography and Hydrophobicity by a Sustainable Two-Steps Phase Separation Process. ACS Sustainable Chemistry & Engineering, 6, 10069-10077. https://doi.org/10.1021/acssuschemeng.8b01407
[22]
National Institute for Occupational Safety and Health (2014) Preventing Adverse Health Effects from Exposure to: Dimethylformamide (DMF) https://www.cdc.gov/niosh/docs/90-105/default.html
[23]
Marshall, J.E., Zhenova, A., Roberts, S., Petchey, T., Zhu, P., Dancer, C.E.J., McElroy, C.R., Kendrick, E. and Goodship, V. (2021) On the Solubility and Stability of Polyvinylidene Fluoride. Polymers, 13, Article 1354. https://doi.org/10.3390/polym13091354
[24]
Gaylord Chemical (2022) Dimethyl Sulfoxide (DMSO) Health and Safety. https://www.gaylordchemical.com/environmental-health-safety/dmso-health-safety
[25]
AZoNano.com (2022) An Introduction to Electrospinning and Nanofibers. https://www.azonano.com/article.aspx?ArticleID=4377
[26]
Bioinicia (2018) Electrospinning Device for Medical Applications. https://bioinicia.com/electrospinning-device-medical-applications
[27]
Hasnidawani, J.N., Azlina, H.N., Norita, H., Bonnia, N.N., Ratim, S. and Ali, E.S. (2016) Synthesis of ZnO Nanostructures Using Sol-Gel Method. Procedia Chemistry, 19, 211-216. https://doi.org/10.1016/j.proche.2016.03.095
[28]
Kalimuldina, G., Turdakyn, N., Abay, I., Medeubayev, A., Nurpeissova, A., Adair, D. and Bakenov, Z. (2020) A Review of Piezoelectric PVDF Film by Electrospinning and Its Applications. Sensors, 20, Article 5214. https://doi.org/10.3390/s20185214
[29]
Yin, Z., Tian, B., Zhu, Q. and Duan, C. (2019) Characterization and Application of PVDF and Its Copolymer Films Prepared by Spin-Coating and Langmuir-Blodgett Method. Polymers, 11, Article 2033. https://doi.org/10.3390/polym11122033
[30]
Cai, X., Lei, T., Sun, D. and Linde, L. (2017) A Critical Analysis of the α, β and γ Phases in Poly(Vinylidene Fluoride) Using FTIR. RSC Advances, 7, 15382-15389. https://doi.org/10.1039/C7RA01267E
[31]
Upadhyay, P., Jain, V., Sharma, S., Shrivastav, A.B. and Sharma, R. (2020) Green and Chemically Synthesized ZnO Nanoparticles: A Comparative Study. IOP Conference Series, 798, Article ID: 012025. https://doi.org/10.1088/1757-899X/798/1/012025
[32]
Cowger, W., Steinmetz, Z., Gray, A., Munno, K., Lynch, J., Hapich, H., Primpke, S., De Frond, H., Rochman, C. and Herodotou, O. (2021) Microplastic Spectral Classification Needs an Open Source Community: Open Specy to the Rescue! Analytical Chemistry, 93, 7543-7548. https://doi.org/10.1021/acs.analchem.1c00123
[33]
Kumarasinghe, H.U., Bandara, L.R.A.K., Bandara, T.M.W.J., Senadeera, G.K.R. and Thotawatthage, C.A. (2021) Fabrication of β-Phase Poly(vinylidene fluoride) Piezoelectric Film by Electrospinning for Nanogenerator Preparations. Ceylon Journal of Science, 50, 357-363. https://doi.org/10.4038/cjs.v50i5.7925
[34]
Goodyear, S. and Aspden, R. (2012) Mechanical Properties of Bone ex Vivo. In: Helfrich, M. and Ralston, S., Eds., Bone Research Protocols, Vol. 816, Humana Press, Totowa, NJ, 555-571. https://doi.org/10.1007/978-1-61779-415-5_35
[35]
TWI Global (2015). https://www.twi-global.com/technical-knowledge/job-knowledge/mechanical-testing-tensile-testing-part-1-069
[36]
Hu, J.Y., Gu, Y.Y., Zhang, H.L., et al. (2018) Effect of Electrode Material on Piezoelectric Output of PVDF Sensor with Electrospun Nanofiber Web. Advanced Materials Letters, 9, 363-368. https://doi.org/10.5185/amlett.2018.1958