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老年2型糖尿病合并冠心病患者发生衰弱的机制及干预措施
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Abstract:
2型糖尿病(Type 2 diabetes mellitus, T2DM)是一种常见的代谢综合征，其中冠状动脉及外周粥样硬动脉化是其常见的大血管并发症，也是造成糖尿病相关发病率和死亡率的主要原因。衰弱是一种临床综合征，其核心是老年人生理储备能力降低和多系统功能失调，而老年糖尿病患者由于胰岛素抵抗及血糖控制不佳等，造成骨骼肌细胞能量代谢障碍，蛋白合成代谢反应下降，较易引起骨骼肌减少症，促进衰弱的发生，另外共存疾病也是发生衰弱的一个重要危险因素，所以2型糖尿病合并冠心病会加速机体衰弱的发生。本文就2型糖尿病合并冠心病患者发生衰弱的机制以及2型糖尿病合并冠心病患者发生衰弱时的干预措施进行综述。
Type 2 diabetes (T2DM) is a common metabolic syndrome, in which coronary artery and peripheral atherosclerotic arterialization are common macrovascular complications, and also the main reason for diabetes related incidence rate and mortality. Weakness is a clinical syndrome, the core of which is the reduction of the physiological reserve capacity of the elderly and the dysfunction of multiple systems. However, the elderly patients with diabetes suffer from insulin resistance and poor blood sugar control, resulting in energy metabolism disorders of skeletal muscle cells, decreased protein anabolism, which is more likely to cause sarcopenia and promote the occurrence of weakness. In addition, coexisting diseases are also an important risk factor for the occurrence of weakness, Therefore, type 2 diabetes combined with coronary heart disease will accelerate the occurrence of body weakness. This article reviews the mechanism of type 2 diabetes with coronary heart disease and the intervention measures for type 2 diabetes with coronary heart disease.
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