Background:There is no study that estimates the prevalence of vernal
keratoconjunctivitis and the association between vernal keratoconjunctivitis
and intestinal parasitic infestation in our setting. Purpose: This study
aimed to estimate the vernal keratoconjunctivitis prevalence, describe the
profile of sensitization and determine the association between vernal
keratoconjunctivitis disease and intestinal parasitic infestation in school
children of Kinshasa during the scholar year from 2022 to 2023. Methods:
An observational, cross-sectional study was performed from September 2022 to
June 2023. The children with vernal keratoconjunctivitis were recruited by
using the four-stage probability sampling technique. Children attending in the
school children of Kinshasa with vernal keratoconjunctivitis were enrolled in
the classroom and underwent a clinical examination and skin prick test for 11
allergens and stool examination direct with microscope in the Laboratory. Data
were entered in Microsoft Sheets using SPSS version 20.0. The Chi-square test
was used to compare the sex, age groups, home environment (grow trees and/or
flowers around the yard), dampness in the house, keeping pets (cat and/or dog),
number of people per household, number of people sharing a bedroom and
intestinal parasitic infestation. The significant level was set to a value of p
< 0.05. Results: A total of 28,800 students from four-stage
probabilist sampling technique in school of Kinshasa were included, and 2100
students had symptoms according to the
vernal keratoconjunctivitis-related symptom questionnaire. Children with
vernal keratoconjunctivitis were enrolled and the mean age ± standard was 7.2 ±
3.7 years, with a prevalence of 7.2% and gender was three boys for one girl.
All vernal keratoconjunctivitis children recruited in urban and rural part had
33.1% positive skin prick test (SPT) and 67.9% showed polysensitization.
Children an urban part was more sensitized than rural respectively with Dermatophagoides
References
[1]
Bauchau, V. and Durham, S.R. (2005) Epidemiological Characterization of the Intermittent and Persistent Types of Allergic Rhinitis. Allergy, 60, 350-353.
https://doi.org/10.1111/j.1398-9995.2005.00751.x
[2]
Petricek, I., Prost, M. and Popova, A. (2006) The Differential Diagnosis of Red Eye: A Survey of Medical Practitioners from Eastern Europe and the Middle East. Ophthalmologica, 220, 229-237. https://doi.org/10.1159/000093076
[3]
Sibanda, E.N. (2003) Inhalant Allergies in Zimbabwe: A Common Problem. International Archives of Allergy and Immunology, 130, 560-565.
https://doi.org/10.1159/000068377
[4]
Abelson, M.B., Smith, L. and Chapin, M. (2003) Ocular Allergic Disease: Mechanisms, Disease Sub-Types, Treatment. The Ocular Surface, 1, 127-149.
https://doi.org/10.1016/S1542-0124(12)70140-4
[5]
Serge, D., Pierre Jean, P., Bruno, M., Laurence, B., Christophe, B., Tristan, B., et al. (2010) Allergie oculaire de la clinique au traitement. MED COM, Paris, 103-265.
[6]
Palmares, J., Delgado, I., Cidade, M., Quadrado, M.J., Filipe, H.P., Gonçalves, L., et al. (2010) Allergic Conjunctivitis: A National Cross-Sectional Study of Clinical Characteristics and Quality of Life. European Journal of Ophthalmology, 20, 257-264.
https://doi.org/10.1177/112067211002000201
[7]
Devogelare, T., Beresniak, A., Raymaeckers, A., Ssi Yan Kai, I. and Brémond-Gignac, D. (2006) Etudes cliniques des compresses dans le traitement de l’allergie saisonnière et per annuelle de l’enfant. Journal Français d’Ophtalmologie, 296, 593-559.
https://doi.org/10.1016/S0181-5512(06)73819-0
[8]
Bremond-Gignac, D., Donadieu, J., Leonardi, A., Pouliquen, P., Doan, S., Chambaretta, F., et al. (2008) Prevalence of Vernal Keratoconjunctivitis: A Rare Disease? British Journal of Ophthalmology, 92, 1097-1102. https://doi.org/10.1136/bjo.2007.117812
[9]
Marey, H.M., Mandour, S.S., El Morsy, O.A., Farahat, H.G. and Shokry, S.M. (2017) Impact of Vernal Keratoconjunctivitis on School Children in Egypt. Seminars in Ophthalmology, 32, 543-549. https://doi.org/10.3109/08820538.2015.1123737
[10]
Hayilu, D., Legesse, K., Lakachew, N. and Asferaw, M. (2016) Prevalence and Associated Factors of Vernal Keratoconjunctivitis among Children in Gondar City, Northwest Ethiopia. BMC Ophthalmology, 16, Article No. 176.
https://doi.org/10.1186/s12886-016-0345-7
[11]
Banla, M., Maneh, N., Vonor, B., Nonon Saa, K.B., Agba, A., Gantin, R.G., et al. (2013) Limbo-conjonctivite endémique des tropiques (LCET) et prise en charge allergologique: Etude préliminaire chez l’enfant togolais. Journal Français d’Ophtalmologie, 4, 677-678. https://doi.org/10.1016/j.jfo.2013.03.008
[12]
Ajaiyeoba, A. (2005) Vernal keratoconjunctivitis and Intestinal Parasitic Infestations in Black Children. Journal of the National Medical Association, 97, 1529-1532.
[13]
De Smedt, S., Nkurikiye, J., Fonteyne, Y., et al. (2011) Vernal Keratoconjunctivitis in School Children in Rwanda and Its Association with Socio-Economic Status: A Population-Based Survey. The American Journal of Tropical Medicine and Hygiene, 4, 711-717. https://doi.org/10.4269/ajtmh.2011.11-0291
[14]
Epée, E., Koki, G., Dohvoma, V.A., et al. (2016) Epidemiological and Clinical Aspects of Tropical Endemic Limbo-Conjunctivitis in Students in Yaoundé. Journal Français d’Ophtalmologie, 39, 744-749. https://doi.org/10.1016/j.jfo.2016.07.009
[15]
Makita, C., Nganga, N. and Diatewa, B. (2015) La Limbo-Conjonctivite Endémique des Tropiques. A Propos de 558 Cas. Revue de Médecine d’Afrique Noire 62, 610-613.
[16]
Muamba, N.L., Kayembe, L.D. and Nyembue, T.D. (2018) Résultats des tests lacrymaux des enfants avec kératoconjonctivite vernale et normaux à Kinshasa. Journal d’épidémiologie et de Santé Publique (JESP), 20, 23-33.
[17]
Chenge, B., Makumyamviri, A.M., Kaimbo, W.A. and Kaimbo, D. (2003) [Tropical Endemic Limbo-Conjunctivitis in Lúbumbashi, Democratic Republic of the Congo]. Bulletin de la Societe Belge d’Ophtalmologie, No. 290, 9-16. (In French)
[18]
Bonini, S., Bonini, S., Lambiase, A., Marchi, S., Pasqualetti, P., Zuccaro, O., Rama, P., Magrini, L., Juhas, T. and Bucci, M.G. (2000) Vernal Keratoconjunctivitis Revisited: A Case Series of 195 Patients with Long-Term Follow Up. Ophthalmology, 107, 1157-1163. https://doi.org/10.1016/S0161-6420(00)00092-0
[19]
Bernstein, I.L. and Storms, W.W. (1995) Practice Parameters for Allergy Diagnostic Testing. Annals of Allergy, Asthma & Immunology, 75, 543-625.
[20]
Hall, A. and Shillo, B. (2005) Allergic Eye Disease, Vernal Keratoconjunctivitis. Community Eye Health Journal, 18, 76-78.
[21]
Shafiq, I. and Shalk, Z.A. (2009) Clinical Presentation of Vernal Keratoconjunctivitis (VKC): A Hospital-Based Study. Journal of Liaquat University of Medical and Health Sciences, 8, 50-54.
[22]
Bonini, S., Coassin, M., Aroni, S. and Lambiase, A. (2004) Vernal Keratoconjunctivitis. Eye, 18, 345-351. https://doi.org/10.1038/sj.eye.6700675
[23]
Nkashama, L.M., Lubeji, D.K., Kasongo, J.C.M., Mutombo, T.K. and Tshipukane, D.N. (2021) Sensitization and Clinical Characteristics of Congolese Children with Vernal Keratoconjunctivitis in Kinshasa. Ocular Immunology and Inflammation, 31, 58-64. https://doi.org/10.1080/09273948.2021.1976217
[24]
Al-Hammadi, S., Zoubeidi, T. and Al-Maskari, F. (2011) Predictors of Childhood Food Allergy: Significance and Implications. Asian Pacific Journal of Allergy and Immunology, 29, 313-317.
[25]
Crespo, J.F., James, J.M., Fernandez-Rodriguez, C. and Rodriguez, J. (2002) Food Allergy: Nuts and Trees. British Journal of Nutrition, 96, S95-S102.
https://doi.org/10.1017/BJN20061869
[26]
Majkowska-Wojciechowska, B., Pełka, J., Korzon, L., et al. (2007) Prevalence of Allergy, Patterns of Allergic Sensitization and Allergy Risk Factors in Rural and Urban Children. Allergy, 62, 1044-1050. https://doi.org/10.1111/j.1398-9995.2007.01457.x
[27]
Annesi-Maesano, I., Moreau, D., Caillaud, D., Lavaud, F., Le Moullec, Y., Taytard, A., Pauli, G. and Charpin, D. (2007) Residential Proximity Fine Particles Related to Allergic Sensitisation and Asthma in Primary School Children. Respiratory Medicine, 101, 1721-1729. https://doi.org/10.1016/j.rmed.2007.02.022
[28]
Boaz, M., Gubert, F., Makabu, T., Munkunda, J.M., Roubaud, F., Saint-Macary, C., Zanuso, C. and Macias, L. (2020) Eau, assainissement, conditions de vie au Congo. Rapport d’analyse de l’enquête de référence pour l’évaluation d’impact du projet PILAEP 2 (Avril-Mai 2018). In: Papiers de Recherche, Agence française de développement, Paris, 1-80. https://doi.org/10.3917/afd.zanus.2020.01.0001