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脑出血机制及治疗的研究进展
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Abstract:
脑出血是指非外伤性脑实质出血是临床上常见的危重性疾病，具有高发病率和死亡率，随着科技水平的提升对脑出血的机制和治疗的研究越来越丰富，本文就脑出血病理机制与当前新型治疗方法作一综述。
Intracerebral hemorrhage refers to non-traumatic cerebral parenchymal hemorrhage, which is a common clinical critical disease with high morbidity and mortality. With the improvement of scien-tific and technological level, the research on the mechanism and treatment of cerebral hemorrhage is becoming more and more abundant. This paper reviews the pathological mechanism and current new treatment methods for cerebral hemorrhage.
| [1] | Sun, T., Zhao, Y., Xiao, Q., et al. (2023) Deferoxamine in Intracerebral Hemorrhage: Systematic Review and Me-ta-Analysis. Clinical Neurology and Neurosurgery, 227, Article ID: 107634.
https://doi.org/10.1016/j.clineuro.2023.107634 |
| [2] | 吴燕平, 李浩, 尤洁. 小胶质细胞极化在脑出血中的研究进展[J]. 四川医学, 2022, 43(12): 1246-1249. |
| [3] | Hua, W., Chen, X., Wang, J., et al. (2020) Mechanisms and Poten-tial Therapeutic Targets for Spontaneous Intracerebral Hemorrhage. Brain Hemorrhages, 1, 99-104. https://doi.org/10.1016/j.hest.2020.02.002 |
| [4] | Asch, C.V., Luitse, M., Rinkel, G., et al. (2010) Incidence, Case Fatality, and Functional Outcome of Intracerebral Haemorrhage over Time, According to Age, Sex, and Ethnic Origin: A Systematic Review and Meta-Analysis. The Lancet Neurology, 9, 167-176. |
| [5] | 王长菊. 1991例脑出血统计分析[J]. 中国老年保健医学, 2013, 11(2): 58-59. |
| [6] | Wilkinson, D.A., Pandey, A.S., Thompson, B.G., et al. (2018) Injury Mechanisms in Acute Intracerebral Hemorrhage. Neuropharmacology, 134, 240-248. https://doi.org/10.1016/j.neuropharm.2017.09.033 |
| [7] | Wan, Y., Holste, K.G., Hua, Y., et al. (2023) Brain Edema Formation and Therapy after Intracerebral Hemorrhage. Neurobiology of Disease, 176, Article ID: 105948. https://doi.org/10.1016/j.nbd.2022.105948 |
| [8] | 沈丁, 贺瑛福. 脑出血后脑水肿机制及治疗研究进展[J]. 中西医结合心血管病电子杂志, 2020, 8(27): 22-23. |
| [9] | 赵晓君, 吴晓光, 王建福. 脑出血继发脑水肿的病理机制研究[J]. 中风与神经疾病杂志, 2016, 33(11): 1054-1056. |
| [10] | Liu, C.M., Shi, B. and Zhou, J. (2014) Effects of Throm-bin on the Secondary Cerebral Injury of Perihematomal Tissues of Rats after Intracerebral Hemorrhage. Genetics and Molecular Research: GMR, 13, 4617-4626.
https://doi.org/10.4238/2014.June.18.4 |
| [11] | 郑岩. HICH患者血清凝血酶、MMP-9水平与脑水肿及神经功能缺损的关系[J]. 检验医学与临床, 2022, 19(1): 80-83. |
| [12] | Zazulia, A., Diringer, M., Derdeyn, C., et al. (1999) Pro-gression of Mass Effect after Intracerebral Hemorrhage. Stroke, 30, 1167-1173. https://doi.org/10.1161/01.STR.30.6.1167 |
| [13] | 刘圣山, 李长清. 铁离子致脑出血后血肿周围组织损伤研究[J]. 重庆医科大学学报, 2008, 33(6): 700-703. |
| [14] | Ren, H., Han, R., Chen, X., et al. (2020) Potential Therapeutic Targets for Intracerebral Hemorrhage-Associated Inflammation: An Update. Journal of Cerebral Blood Flow & Metabolism, 40, 1752-1768.
https://doi.org/10.1177/0271678X20923551 |
| [15] | Yao, Y. and Tsirka, S. (2012) Chemokines and Their Receptors in Intracerebral Hemorrhage. Translational Stroke Research, 3, 70-79. https://doi.org/10.1007/s12975-012-0155-z |
| [16] | Lattanzi, S., Napoli, M.D., Ricci, S., et al. (2020) Matrix Metallo-proteinases in Acute Intracerebral Hemorrhage. Neurotherapeutics, 17, 484-496. https://doi.org/10.1007/s13311-020-00839-0 |
| [17] | Mracsko, E., Javidi, E., Na, S., et al. (2014) Leukocyte Invasion of the Brain after Experimental Intracerebral Hemorrhage in Mice. Stroke, 45, 2107-2114. https://doi.org/10.1161/STROKEAHA.114.005801 |
| [18] | Butcher, K., Jeerakathil, T., Hill, M., et al. (2013) Abstract 113: The Intracerebral Haemorrhage Acutely Decreasing Arterial Pressure Trial (ICH ADAPT): Final Results. Stroke, 44, A113. https://doi.org/10.1161/str.44.suppl_1.A113 |
| [19] | Anderson, C.S., Heeley, E., Huang, Y., et al. (2013) Rap-id Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage. New England Journal of Medicine, 368, 2355-2365. https://doi.org/10.1056/NEJMoa1214609 |
| [20] | Hemphill, J., Greenberg, S. anderson, C., et al. (2015) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke, 46, 2032-2060. https://doi.org/10.1161/STR.0000000000000069 |
| [21] | Moullaali, T.J., Wang, X., Martin, R.H., et al. (2019) Blood Pressure Control and Clinical Outcomes in Acute Intracerebral Haemorrhage: A Preplanned Pooled Analysis of Intdidual Participant Data. The Lancet Neurology, 18, 857-864.
https://doi.org/10.1016/S1474-4422(19)30196-6 |
| [22] | Qureshi, A.I., Palesch, Y.Y., Barsan, W.G., et al. (2016) In-tensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. New England Journal of Medicine, 375, 1033-1043. https://doi.org/10.1056/NEJMoa1603460 |
| [23] | 陈瑶枝, 刘丽萍. 急性脑出血早期血肿扩大止血治疗研究进展[J]. 中国卒中杂志, 2016, 11(5): 408-413. |
| [24] | 李育健, 郑峻. 自发性脑出血血肿扩大机制及止血治疗进展[J]. 中国现代神经疾病杂志, 2021, 21(2): 94-100. |
| [25] | Sprigg, N., Renton, C.J., Dineen, R.A., et al. (2014) Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23, 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007 |
| [26] | 冯宁, 张俊义, 王建军. 高血压脑出血的发病机制与手术方式的研究进展[J]. 世界最新医学信息文摘, 2016, 16(12): 25-26. |
| [27] | 李元贵, 杨燕文, 王晓麒, 等. 软通道血肿穿刺引流术与神经内镜颅内血肿清除术治疗高血压脑出血的疗效[J]. 实用医学杂志, 2023, 39(7): 833-837. |
| [28] | Montes, J., Wong, J., Fayad, P., et al. (2000) Stereotactic Computed Tomographic-Guided Aspiration and Thrombolysis of Intracerebral Hematoma？: Protocol and Preliminary Experience. Stroke, 31, 834-840.
https://doi.org/10.1161/01.STR.31.4.834 |
| [29] | Zou, Y., Liao, L., Dai, J., et al. (2023) Mesenchymal Stem Cell-Derived Extracellular Vesicles/Exosome: A Promising Therapeutic Strategy for Intracerebral Hemorrhage. Regener-ative Therapy, 22, 181-190.
https://doi.org/10.1016/j.reth.2023.01.006 |
| [30] | Peplow, P. and Martinez, B. (2017) Blood microRNAs as Potential Diagnostic Markers for Hemorrhagic Stroke. Neural Regeneration Research, 12, 13-18. https://doi.org/10.4103/1673-5374.198965 |
| [31] | Cheng, X. ander, B., Jickling, G., et al. (2020) MicroRNA and Their Target mRNAs Change Expression in Whole Blood of Patients after Intracerebral Hemorrhage. Journal of Cere-bral Blood Flow & Metabolism, 40, 775-786.
https://doi.org/10.1177/0271678X19839501 |
| [32] | Xi, T., Jin, F., Zhu, Y., et al. (2018) miR-27a-3p Protects against Blood-Brain Barrier Disruption and Brain Injury after Intracerebral Hemorrhage by Targeting Endothelial Aquaporin-11. The Journal of Biological Chemistry, 293, 20041-20050.
https://doi.org/10.1074/jbc.RA118.001858 |
