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肝细胞癌中的铁死亡与氧化应激
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Abstract:
肝细胞癌(Hepatic Cellular Carcinoma, HCC)是全球发病率较高的癌症之一且其死亡率在全球每年持续增加约2%~3%。氧化应激(Oxidative Stress, OS)是指当生物体细胞在遭遇外界刺激时，机体细胞内部产生大量超氧化物，如单线态氧(1O2)、过氧化氢(H2O2)，超氧阴离子(O2-)等，这些物质致机体细胞内氧化与抗氧化作用失衡，最终导致细胞和组织的损伤。氧化应激被认为是恶性肿瘤的起因之一。铁死亡(Ferroptosis)是近年发现的一种铁依赖性的新型细胞程序性死亡方式。本文主要阐述了肝细胞癌中氧化应激对铁死亡的影响的相关研究进展。
Hepatic cellular carcinoma (HCC) is one of the most prevalent cancers worldwide, whose mortality rate continues to increase by about 2%~3% per year. Oxidative stress (OS) refers to the production of a large amount of superoxide inside the body when the organism cells are exposed to external stimuli, such as singlet oxygen (1O2), hydrogen peroxide (H2O2), superoxide anions (O2-), etc. These substances cause the imbalance of oxidation and antioxidant in the body’s cells, and eventually lead to damage to cells and tissues. Oxidative stress is thus considered to be one of the major causes of malignant tumors. Ferroptosis is a novel form of iron-dependent programmed cell death discovered in recent years. This article mainly describes the research progress on the effects of oxidative stress on ferroptosis in hepatocellular carcinoma.
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