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老年慢性阻塞性肺疾病合并衰弱的研究进展
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Abstract:
对于慢性阻塞性肺疾病(COPD)患者来说,衰弱常与之伴随。尽管COPD患者的衰弱症状尚未得到完全的界定,但长期以来,人们普遍认可,病人衰弱状态的评估不仅是治愈疾病的关键,而且也是老年学科未来发展的基础,它可能极大地降低病人的生存率、改善其病情预后以及医疗保健利用。本文从衰弱的定义与内涵、衰弱的评估工具、COPD与衰弱共同的发病机制、主要危险因素、干预措施方法进行综述,旨在于早期识别COPD合并衰弱的高危患者并及时干预,为改善这些患者的临床预后和提高其生活质量提供新的视角和临床实践依据。
For patients with chronic obstructive pulmonary disease, weakness is often accompanied. The sig-nificance of physical weakness in COPD patients has been long recognized as having direct, inde-pendent effects on treatment and can detrimentally influence the quality of life, outlook, and medi-cal care utilization of those afflicted. However, no definitive definition exists for its characteristics. This article delves into the definition and implications of weakness, evaluates its assessment tools, examines its common source, identifies primary risk factors and proposes interventions for COPD and weakness, with the aim of identifying those at high risk of developing COPD with weakness and providing a fresh outlook and clinical practice for bettering their clinical outlook and enhancing their quality of life.
[1] | 刘婉莹, 姚欣. 慢性阻塞性肺疾病急性加重: 现况与挑战[J]. 国际呼吸杂志, 2023, 43(2): 143-146. |
[2] | 白亚虎, 高胜寒, 纪思禹. 慢性阻塞性肺疾病向前发展[J]. 中国全科医学, 2023, 26(3): 46-50. |
[3] | 张新, 贾俊青. 营养支持及呼吸康复治疗对改善COPD患者肺功能的作用[J]. 中国现代医药杂志, 2018, 18(6): 106-108. |
[4] | Rodri-guez, L. (2018) The Prevalence and Correlates of Frailty in Urban and Rural Populations in Latin America, China, and India: A 10/66 Population-Based Survey. Journal of the American Medical Directors Association, 43, 287-295.
https://doi.org/10.1016/j.jamda.2017.09.026 |
[5] | Bandeen-Roche, K., et al. (2020) Principles and Issues for Phys-ical Frailty Measurement and Its Clinical Application. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75, 1107-1112.
https://doi.org/10.1093/gerona/glz158 |
[6] | Lewsey, S.C., et al. (2020) Exercise Intolerance and Rapid Skeletal Muscle Energetic Decline in Human Age-Associated Frailty. JCI Insight, 5, Article ID: 141246. https://doi.org/10.1172/jci.insight.141246 |
[7] | 于普林, 王建业. 加强老年人衰弱综合征的防治研究[J]. 中华老年护理学杂志, 2015, 34(12): 1281-1281. |
[8] | 姜珊, 赵丽娜, 李胜利. 住院患者衰弱情况及其影响因素分析[J]. 中华老年医学杂志, 2017, 36(6): 23-25. |
[9] | Fisher, K., Griffith, L.E., Gruneir, A., et al. (2021) Effect of So-cio-Demographic and Health Factors on the Association between Multimorbidity and Acute Care Service Use: Popula-tion-Based Survey Linked to Health Administrative Data. BMC Health Services Research, 21, Article No. 62. https://doi.org/10.1186/s12913-020-06032-5 |
[10] | Pivetta, N.R.S., Marincolo, J.C.S., Aprahamian, I., et al. (2020) Multimorbidity, Frailty and Functional Disability in Octogenarians: A Structural Equation Analysis of Relationship. Ar-chives of Gerontology and Geriatrics, 86, Article ID: 103931. https://doi.org/10.1016/j.archger.2019.103931 |
[11] | Wang, Z., Peng, W., Li, M., Li, X., Yang, T., Li, C., Yan, H., Jia, X., Hu, Z. and Wang, Y. (2021) Association between Multimorbidity Patterns and Disability among Older People Covered by Long-Term Care Insurance in Shanghai, China. BMC Public Health, 21, Article No. 418. https://doi.org/10.1186/s12889-021-10463-y |
[12] | 王翎羽, 胡小龙, 王雪静. 基于老年综合评估的衰弱指数对缺血性脑卒中患者衰弱的预测价值[J]. 中华现代护理杂志, 2022, 28(2): 54-57. |
[13] | 钱绪芬, 王庆芳, 韩婷. 老年COPD患者衰弱现状及影响因素分析[J]. 中华现代护理杂志, 2021, 27(36): 345-350. |
[14] | 朱倩如, 孙君凡, 朱静. 家庭有氧运动结合呼吸训练在COPD合并衰弱患者中的应用[J]. 中华现代护理杂志, 2020, 26(16): 67-70. |
[15] | Kortebein, P., Symons, T.B., Ferrando, A., et al. (2018) Functional Impact of 10 Days of Bed Rest in Healthy Older Adults. The Journals of Gerontology Series A Biological Sciences and Medical Sciences, 63, 1076-1081.
https://doi.org/10.1093/gerona/63.10.1076 |
[16] | Narang, V., Lu, Y., Tan, C., et al. (2021) Influenza Vac-cine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly with Natural Influ-enza Exposure. Frontiers in Immunology, 9, Article No. 2465.
https://doi.org/10.3389/fimmu.2018.02465 |
[17] | 陈丹丹, 方婷婷, 丁怡. 胸腔镜肺叶切除术老年患者术前衰弱与术后肺部并发症的关系[J]. 中华麻醉学杂志, 2021, 41(8): 68-70. |
[18] | 田刚, 辛昊洋, 郭从涛, 等. 慢性阻塞性肺疾病患者衰弱发生情况和危险因素分析[J]. 中华保健医学杂志, 2018, 20(3): 224-227. |
[19] | Lees, C., et al. (2022) Frailty Hinders Recovery from Influenza and Acute Respiratory Illness in Older Adults. The Journal of Infectious Diseases, 3, 428-437. |
[20] | 任青卓. 社区老年人衰弱筛查工具的引进及衰弱预防管理策略研究[D]: [硕士学位论文]. 广州: 南方医科大学, 2019. |
[21] | 张启晨, 陈洁. 衰弱症与代谢综合征、肠道菌群研究进展[J]. 中国老年学杂志, 2020, 38(19): 235-239. |
[22] | 李凌, 王玉梅, 张艳玲, 等. 老年病人衰弱综合征与肌肉功能的相关性研究[J]. 护理研究, 2020, 33(6): 917-920. |
[23] | 夏魁, 朱纯儒, 孙伟, 等. 老年慢性阻塞性肺病患者衰弱现状调查及危险因素分析[J]. 中国临床保健杂志, 2019, 22(2): 220-223. |
[24] | Alvarez-Satta, M., Berna-Erro, A., Carrasco-Garcia, E., et al. (2020) Relevance of Oxidative Stress and Inflammation in Frailty Based on Human Studies and Mouse Models. Aging (Albany NY), 12, 9982-9999.
https://doi.org/10.18632/aging.103295 |
[25] | Rashidi Pour Fard, N., Amirabdollahian, F. and Haghighatdoost, F. (2019) Dietary Patterns and Frailty: A Systematic Review and Meta-Analysis. Nutrition Reviews, 77, 498-513. https://doi.org/10.1093/nutrit/nuz007 |
[26] | 方向阳, 陈清, 侯原平, 等. 社区老年人衰弱相关因素[J]. 中国老年学杂志, 2019, 39(2): 216-219. |
[27] | 张园, 苏春燕. COPD患者肺康复管理的研究进展[J]. 中华现代护理杂志, 2021, 27(30): 87-90. |
[28] | 雷翠芳. 早期肺康复训练对慢性阻塞性肺疾病无创机械通气患者呼吸功能的影响[J]. 医疗装备, 2021, 34(3): 181-182. |
[29] | 徐璐. 集束化肺康复护理在慢性阻塞性肺疾病患者康复中的应用效果[J]. 国际护理学杂志, 2020, 39(22): 87-89. |
[30] | Maddocks, M., Kon, S.S., Canavan, J.L., et al. (2016) Physical Frailty and Pulmonary Rehabilitation in COPD: A Prospective Cohort Study. Thorax, 71, 988-995. https://doi.org/10.1136/thoraxjnl-2016-208460 |
[31] | Castellana, F., Lampignano, L., et al. (2021) Physical Frailty, Multimorbidity, and All-Cause Mortality in an Older Population from Southern Italy: Results from the Salus in Apulia Study. Journal of the American Medical Directors Association, 22, 598-605. https://doi.org/10.1016/j.jamda.2020.12.026 |
[32] | Panza, F., Lozupone, M., Solfrizzi, V., Sardone, R., Dibello, V., Di Lena, L., D’Urso, F., Stallone, R., Petruzzi, M., Giannelli, G., et al. (2018) Different Cognitive Frailty Models and Health- and Cognitive-Related Outcomes in Older Age: From Epidemiology to Prevention. Alzheimer’s Disease, 62, 993-1012. https://doi.org/10.3233/JAD-170963 |
[33] | Belur, J., Tompson, L. and Simon, M. (2021) Interrater Relia-bility in Systematic Review Methodology: Exploring Variation in Coder Decision-Making. Sociological Methods & Re-search, 50, 837-865.
https://doi.org/10.1177/0049124118799372 |
[34] | 陶爱萍, 陈小伊, 陈海丽, 等. 温州市养老机构老年人衰弱现状与营养不良相关性研究[J]. 护士进修杂志, 2020, 35(21): 1988-1993. |
[35] | Ando, K., Kobayashi, K., et al. (2020) Higher Extra-Cellular Water-to-Total Body Water Ratio More Strongly Reflects the Locomotive Syndrome Risk and Frailty than Sarcopenia. Archives of Gerontology and Geriatrics, 88, Article ID: 104042. https://doi.org/10.1016/j.archger.2020.104042 |
[36] | 戈玉杰, 吴庆文, 高志鹏, 等. 简式太极拳训练对老年衰弱前期衰弱水平和平衡能力的影响[J]. 中国老年学杂志, 2020, 40(3): 563-566. |
[37] | Grubbs, B.F., Figueroa, A., Kim, J.S., et al. (2020) Whole-Body Vibration Training in Frail, Skilled Nursing Home Residents. International Journal of Exercise Science, 13, 140-156. |
[38] | 张爽, 陈影, 孙娜雅, 等. 综合运动训练对老年糖尿病患者衰弱和躯体功能的影响[J]. 中华护理杂志, 2020, 55(10): 1445-1451. |
[39] | 金蓉, 等. 邯郸市社区老年人健康促进生活方式现状及其影响因素[J]. 中国老年学杂志, 2018, 38(8): 1984-1986. |
[40] | Hewitt, D. and Booth, M.G. (2020) The FRAIL-FIT Study: Frailty’s Relationship with Adverse-Event Incidence in the Longer Term, at One Year Following Intensive Care Unit Treatment—A Retrospective Observational Cohort Study. Journal of the Intensive Care Society, 21, 435-440. https://doi.org/10.1177/1751143719838212 |