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孤儿核受体Nur77在凋亡和炎症中的研究进展
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Abstract:
孤儿核受体Nur77作为核受体的一类，参与机体生理和病理状态下的多个过程。Nur77可以参与细胞分化、凋亡、代谢和炎症等诸多反应，在动脉粥样硬化、骨质疏松、心肌梗死、哮喘、急性肺损伤等诸多疾病的发生发展中都起到了重要的作用。但是对于Nur77的研究较少，本篇文章就Nur77分子参与的凋亡以及炎症反应过程以及相关机制进行综述，有助于Nur77在疾病中的进一步研究。
Orphan nuclear receptor Nur77, as a class of nuclear receptors, is involved in several processes in the physiological and pathological state of the body. Nur77 can participate in many reactions, such as cell differentiation, apoptosis, metabolism and inflammation. And it plays an important role in the occurrence and development of many diseases, such as atherosclerosis, osteoporosis, myocardi-al infarction, asthma, acute lung injury and so on. However, there are few studies on Nur77, and this article reviews the apoptosis and inflammatory response processes and related mechanisms in-volved in Nur77 molecules, which is helpful for further research on Nur77 in diseases.
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