|
基于“胃脘下俞”穴治疗糖尿病研究进展
|
Abstract:
糖尿病已成为全球健康的主要威胁,文章通过探究胃脘下俞穴治疗糖尿病的临床疗效、相关指标的实验研究及其影响,进一步论述其作用途径,以期为胃脘下俞穴的临床应用提供理论依据,为糖尿病的治疗提供新思路。
Diabetes has become a major threat to global health. By exploring the clinical efficacy of weiwanxiashu point in the treatment of diabetes, the experimental research on relevant indicators and its impact, this paper further discusses its action path, in order to provide a theoretical basis for the clinical application of weiwanxiashu point and provide a new idea for the treatment of diabetes.
[1] | Saeedi, P., Petersohn, I., Salpea, P., et al. (2019) Global and Regional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice, 157, Article ID: 107843. https://doi.org/10.1016/j.diabres.2019.107843 |
[2] | 涂珺, 许文华. 糖尿病临床分型及治疗药物的研究进展[J]. 中药新药与临床药理, 2022, 33(4): 557-564. |
[3] | 陈员秀. 针药并用对2型糖尿病合并肥胖患者胰岛素抵抗及生化代谢的影响[J]. 上海针灸杂志, 2011, 32(11): 911-913. |
[4] | 杜月薇, 陈松鹤, 高颜华, 等. 2型糖尿病住院患者背俞穴反应点分布规律研究[J]. 中华中医药杂志, 2021, 36(2): 1105-1108. |
[5] | 刘会霞, 刘丽莎, 袁秀丽, 等. 基于数据挖掘针灸治疗2型糖尿病选穴规律探析[J]. 四川中医, 2019, 37(1): 210-213. |
[6] | 曹昺焱, 李瑞, 田环环, 等. 电针大鼠背俞穴降糖作用的实验研究[J]. 中国针灸, 2016, 36(12): 1283-1287. |
[7] | 田环环. 基于MST1探究电针“胰俞”、“脾俞”、“肾俞”干预T2DM的机制[D]: [博士学位论文]. 北京: 北京中医药大学, 2017. |
[8] | 芭迪斯(Mahmoud Bagheri). 针刺胃脘下俞穴对2型糖尿病患者即时血糖水平的影响[D]: [硕士学位论文]. 北京: 北京中医药大学, 2019. |
[9] | da Silva, W.B., da Silva, F.P. and Cordeiro, E. (2018) Influência do ponto extra Weiguanxiashu na diabetes tipo 2: Relato de caso. Revista Científica do HCE, 1, 20-27. |
[10] | 廖辉, 席萍, 陈强, 等. 针刺、艾灸、针加灸胃脘下俞穴治疗糖尿病临床观察[J]. 中国针灸, 2007(7): 482-484. |
[11] | Miguna, B. (2014) Effect of Yishu Point on Pancreatic β-Cell Function in Type 2 Diabetes. Guangzhou University of Chinese Medicine, Guangzhou. |
[12] | 董卫. 胃脘下俞穴埋线法治疗糖尿病临床研究[J]. 中国针灸, 2002, 22(10): 653-655. |
[13] | 张中新, 刘建玉, 李民兰. 胰俞穴埋药线治疗2型糖尿病临床报道[J]. 针灸临床杂志, 2005, 21(6): 40-41. |
[14] | 童青, 乐嘉宜. 按压胰俞穴辅助治疗2型糖尿病95例[J]. 河南中医, 2020, 40(6): 918-921. |
[15] | 吴志明, 杨云, 吴冠儒, 等. 胃脘下俞穴埋线对糖尿病家兔血糖影响的实验观察[J]. 中国中医药现代远程教育, 2011, 9(22): 132-134. |
[16] | 曾志勇, 李永义. 针刺胃脘下俞和足三里穴对糖尿病家兔血糖及血浆胰高血糖素的影响[J]. 成都中医药大学学报, 2000, 23(2): 40-41+45. |
[17] | 高珊, 李瑞, 田环环, 等. 电针“胰俞”穴对2型糖尿病大鼠HPA轴相关激素的影响[J]. 中国针灸, 2014, 34(11): 1099-1105. |
[18] | 乔野, 张立德. “胰俞”穴针刺加刺络放血对大鼠血糖调节作用的影响[J]. 实用中医内科杂志, 2010, 24(11): 45-46. |
[19] | 石锦萍, 钟柏松, 毛敬伟, 等. 胃脘下俞与胰腺相关性的实验研究[J]. 中国针灸, 2001, 21(8): 485-487. |
[20] | 武燕, 李瑞, 田环环, 等. 电针“胃脘下俞”对2型糖尿病大鼠血糖及血清瘦素影响的实验研究[J]. 针灸临床杂志, 2014, 30(3): 56-58. |
[21] | 田环环, 高珊, 曹昺焱, 等. 电针胰俞穴对2型糖尿病大鼠胰岛素敏感指数、脂联素水平的影响[J]. 针灸临床杂志, 2014, 30(8): 56-60. |
[22] | Ardestani, A., Li, S., Annamalai, K., et al. (2019) Neratinib Protects Pancreatic Beta Cells in Diabetes. Nature Communications, 10, Article No. 5015. https://doi.org/10.1038/s41467-019-12880-5 |
[23] | 曹昺焱, 李瑞, 田环环, 等. 电针“胃脘下俞”对2型糖尿病大鼠胰岛形态及胰腺胰高血糖素样肽1受体的影响[J]. 针刺研究, 2017, 42(2): 107-113. |
[24] | Jusuf, A.A., Viventius, Y. and Djaali, W. (2021) Comparison between the Effectiveness of Manual Acupuncture and Laser Acupuncture at EX-B3 Weiwanxiashu in a Rat Model of Type 2 Diabetes. Journal of Acupuncture and Meridian Studies, 14, 75-81. https://doi.org/10.51507/j.jams.2021.14.2.75 |
[25] | Rains, J.L. and Jain, S.K. (2011) Oxidative Stress, Insulin Signaling, and Diabetes. Free Radical Biology and Medicine, 50, 567-575. https://doi.org/10.1016/j.freeradbiomed.2010.12.006 |
[26] | Yin, Y., Zheng, Z. and Jiang, Z. (2019) Effects of Lycopene on Metabolism of Glycolipid in Type 2 Diabetic Rats. Biomedicine & Pharmacotherapy, 109, 2070-2077. https://doi.org/10.1016/j.biopha.2018.07.100 |
[27] | 马艳佳, 李瑞, 贾宁, 等. 电针对2型糖尿病大鼠糖代谢及血清SOD、MDA含量的影响[J]. 针灸临床杂志, 2017, 33(3): 53-56. |
[28] | 赵荷珺, 李兴. 瘦素与胰岛素抵抗的研究进展[J]. 医学综述, 2010, 16(11): 1684-1687. |
[29] | 张炜, 张征, 徐尔理. 高血糖患者皮质醇分泌情况的临床观察[J]. 中国糖尿病杂志, 2014, 22(11): 1015-1020. |
[30] | Chan, O., Chan, S., Inouye, K., et al. (2002) Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but Not Epinephrine Responses. Diabetes, 51, 1681-1689.
https://doi.org/10.2337/diabetes.51.6.1681 |
[31] | Ahrén, B. (2011) GLP-1 for Type 2 Diabetes. Experimental Cell Research, 317, 1239-1245.
https://doi.org/10.1016/j.yexcr.2011.01.010 |
[32] | Melloul, D., Marshak, S. and Cerasi, E. (2002) Regulation of pdx-1 Gene Expression. Diabetes, 51, S320-S325.
https://doi.org/10.2337/diabetes.51.2007.S320 |
[33] | Ardestani, A., Paroni, F., Azizi, Z., et al. (2014) MST1 Is a Key Regulator of Beta Cell Apoptosis and Dysfunction in Diabetes. Nature Medicine, 20, 385-397. https://doi.org/10.1038/nm.3482 |
[34] | Ardestani, A. and Maedler, K. (2016) MST1: A Promising Therapeutic Target to Restore Functional Beta Cell Mass in Diabetes. Diabetologia, 59, 1843-1849. https://doi.org/10.1007/s00125-016-3892-9 |
[35] | Zhou, D.L., et al. (2012) Effects and Mechanism of Duodenal-Jejunal Bypass and Sleeve Gastrectomy on GLUT2 and Glucokinase in Diabetic Goto-Kakizaki Rats. European Journal of Medical Research, 17, Article No. 15.
https://doi.org/10.1186/2047-783X-17-15 |
[36] | Xu, L., Zheng, D., Wang, L., et al. (2014) GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease. BioMed Research International, 2014, Article ID: 151723. https://doi.org/10.1155/2014/151723 |
[37] | Waeber, G., Thompson, N., Nicod, P., et al. (1996) Transcriptional Activation of the GLUT2 Gene by the IPF-1/ STF-1/IDX-1 Homeobox Factor. Molecular Endocrinology, 10, 1327-1334.
https://doi.org/10.1210/mend.10.11.8923459 |
[38] | 裴恩实. 不同神经节段“胰俞”和“肾俞”对T2DM大鼠作用机制的实验研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2014. |
[39] | Wasserfall, C., Nick, H.S., Camp-bell-Thompson, M., et al. (2017) Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata. Cell Metabolism, 26, 568-575.e3.
https://doi.org/10.1016/j.cmet.2017.08.013 |
[40] | Pfützner, A., Pfützner, A.H., Larbig, M., et al. (2004) Role of Intact Proinsulin in Diagnosis and Treatment of Type 2 Diabetes Mellitus. Diabetes Technology & Therapeutics, 6, 405-412. https://doi.org/10.1089/152091504774198124 |
[41] | 武燕. 电针“胰俞”对T2DM大鼠胰岛素原mRNA表达的调控及对其血糖影响的实验研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2014. |