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中药复方调控MAPK信号通路治疗肺癌的研究进展
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Abstract:
肺癌作为一种发病率和死亡率极高的恶性肿瘤，对人类的生命健康有着重大威胁。现代药理实验研究表明中医药可以通过调控相关信号通路进行肺癌干预，MAPK信号通路作为调节参与恶性肿瘤发生的关键信号通路，在肿瘤发展过程中起着关键作用。中药复方作为中医中药的精华，具有多成分、多靶标及多通路的独特优势，中药复方抗癌研究近年来已逐步成为抗肺癌药物研究热点之一。本文通过对以中药复方调控与肺癌密切相关的MAPK信号通路治疗肺癌近年的国内、外相关文献进行检索分析，从中药复方调控信号通路干预肺癌肿瘤细胞凋亡自噬、生长侵袭以及肿瘤血管生成等相关机制方面进行归纳与总结，希望能够为研究中医药干预MAPK信号通路治疗肺癌的作用机制、开发研究中药组方治疗肺癌以及发现新的药物作用靶点提供新思路。
As a kind of lung cancer incidence and high mortality rate of malignant tumor, significant threats to human life and health. Modern pharmacological studies have shown that Chinese medicine can regulate and control related signaling pathway in lung cancer by intervention, MAPK signaling pathways as a key signaling pathways regulating participates in malignant tumor, plays a key role in the process of tumor development. Traditional Chinese medicine compound as the essence of traditional Chinese medicine, with multiple components, multiple targets and pathways of the unique advantages, Chinese medicine compound anti-cancer research in recent years has gradually become one of research hot spot in lung cancer drug resistance. This article through to traditional Chinese medicine compound regulation and MAPK signal pathways in the lung cancer is closely related to the treatment of lung cancer in recent years, the related literature at home and abroad were reviewed analysis, from the traditional Chinese medicine compound control signaling pathways intervention lung tumor cell apoptosis, autophagy, invasive growth as well as the mechanism of tumor angiogenesis related aspects are summarized and the summary, hope to study the mechanism of action of intervention MAPK signal pathway of traditional Chinese medicine treatment of lung cancer and traditional Chinese medicine formula to treat lung cancer research development, and discover new drug targets to provide new way of thinking.
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