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脂蛋白与心血管疾病残余风险的研究现状
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Abstract:
尽管心血管疾病的防治取得了较为突出的成果，但其患病率和病死率仍较高。目前的指南针对降低低密度脂蛋白胆固醇(LDL-C)浓度，以减少动脉粥样硬化性心血管疾病(ASCVD)风险，尽管积极降低LDL-C，但残留ASCVD风险仍然存在，因此积极预防及治疗心血管疾病迫在眉睫，寻求新的方法降低心血管疾病的残余风险具有重要临床意义。本文主要总结了脂蛋白(LDL-C, HDL-C, TG, RLPs, Lp(a))与心血管疾病残余风险有关的证据。
Although the prevention and treatment of cardiovascular diseases have made remarkable achievements, the prevalence and mortality of cardiovascular diseases are still high. Current guide-lines aim to reduce the concentration of low-density lipoprotein cholesterol (LDL-C) to reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Despite aggressive lowering of LDL-C, the risk of residual ASCVD remains, making active prevention and treatment of cardiovascular disease urgent. It is of great clinical significance to seek new methods to reduce the residual risk of cardio-vascular disease. This review summarizes the evidence that lipoproteins (LDL-C, HDL-C, TG, RLPs, Lp(a)) are associated with residual risk of cardiovascular disease.
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