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偏头痛与卒中共病的研究进展
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Abstract:
偏头痛和卒中是神经内科常见疾病，同时也是全球残疾的主要原因。众所周知，偏头痛患者以育龄期女性多见，而卒中以老年男性多见。已有的研究表明偏头痛患者的总体卒中风险增加，主要以有先兆偏头痛为主，而无先兆偏头痛与卒中的风险尚有争议。偏头痛与卒中共病的机制也尚不明确。为此我们从流行病学研究、偏头痛的神经影像学、偏头痛与缺血性卒中的可能的机制等方面阐述偏头痛与卒中共病的复杂关联。
Migraine and stroke are common neurological disorders and are also major causes of disability worldwide. It is well known that migraine patients are mostly women of childbearing age, while stroke is more common in elderly men. Some studies have shown an increased risk of stroke overall in migraine patients, mainly with migraine with aura, while the risk of stroke with migraine without aura was controversial. The mechanism of comorbidity between migraine and stroke is also unclear. Therefore, we describe the complex association on comorbidity of migraine and stroke from the as-pects of epidemiological studies, neuroimaging of migraine, and possible mechanism of migraine and ischemic stroke.
| [1] | Safiri, S., Pourfathi, H., Eagan, A., et al. (2022) Global, Regional, and National Burden of Migraine in 204 Countries and Territories, 1990 to 2019. Pain, 163, e293-e309. https://doi.org/10.1097/j.pain.0000000000002275 |
| [2] | Zhang, S., Liu, H. and Shi, T. (2022) Association between Migraine and Risk of Stroke: A Systematic Review and Meta-Analysis. Neurological Sciences, 43, 4875-4889. https://doi.org/10.1007/s10072-022-06074-z |
| [3] | Hu, X.M., Zhou, Y.C., Zhao, H.Y. and Peng, C. (2017) Migraine and the Risk of Stroke: An Updated Meta-Analysis of Prospective Cohort Studies. Neurological Sciences, 38, 33-40. https://doi.org/10.1007/s10072-016-2746-z |
| [4] | Oie, L.R., Kurth, T., Gulati, S. and Dodick, D.W. (2020) Migraine and Risk of Stroke. Journal of Neurology, Neurosurgery and Psychiatry, 91, 593-604. https://doi.org/10.1136/jnnp-2018-318254 |
| [5] | Etminan, M., Takkouche, B., Isorna, F.C. and Samii, A. (2005) Risk of Ischaemic Stroke in People with Migraine: Systematic Review and Meta-Analysis of Observational Studies. BMJ, 330, 63-65.
https://doi.org/10.1136/bmj.38302.504063.8F |
| [6] | Durham, N.C. (1975) Oral Contraceptives and Stroke in Young Women. Associated Risk Factors. JAMA, 231, 718-722.
https://doi.org/10.1001/jama.231.7.718 |
| [7] | Schurks, M., Rist, P.M., Bigal, M.E., et al. (2009) Migraine and Car-diovascular Disease: Systematic Review and Meta-Analysis. BMJ, 339, b3914. https://doi.org/10.1136/bmj.b3914 |
| [8] | Sacco, S. and Kurth, T. (2014) Migraine and the Risk for Stroke and Car-diovascular Disease. Current Cardiology Reports, 16, Article No. 524. https://doi.org/10.1007/s11886-014-0524-1 |
| [9] | Vetvik, K.G. and Macgregor, E.A. (2017) Sex Differences in the Epidemiology, Clinical Features, and Pathophysiology of Migraine. The Lancet Neurology, 16, 76-87. https://doi.org/10.1016/S1474-4422(16)30293-9 |
| [10] | Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd Edition. Cephalalgia, 38, 1-211. https://doi.org/10.1177/0333102417738202 |
| [11] | Spector, J.T., Kahn, S.R., Jones, M.R., et al. (2010) Mi-graine Headache and Ischemic Stroke Risk: An Updated Meta-Analysis. The American Journal of Medicine, 123, 612-624. https://doi.org/10.1016/j.amjmed.2009.12.021 |
| [12] | Mahmoud, A.N., Mentias, A., Elgendy, A.Y., et al. (2018) Migraine and the Risk of Cardiovascular and Cerebrovascular Events: A Meta-Analysis of 16 Cohort Studies In-cluding 1, 152, 407 Subjects. BMJ Open, 8, e020498.
https://doi.org/10.1136/bmjopen-2017-020498 |
| [13] | 张依, 韩燕飞, 董威, 等. 常见的脑卒中模拟病及其与急诊卒中的鉴别[J]. 临床神经病学杂志, 2018, 31(6): 472-473. |
| [14] | Otlivanchik, O. and Liberman, A.L. (2019) Migraine as a Stroke Mimic and as a Stroke Chameleon. Current Pain and Headache Reports, 23, Article No. 63. https://doi.org/10.1007/s11916-019-0801-1 |
| [15] | Terrin, A., Toldo, G., Ermani, M., Mainardi, F. and Maggioni, F. (2018) When Migraine Mimics Stroke: A Systematic Review. Cephalalgia, 38, 2068-2078. https://doi.org/10.1177/0333102418767999 |
| [16] | 范学慧, 钟镝, 陈洪苹, 等. 急诊卒中模拟病的鉴别及静脉溶栓的安全性研究进展[J]. 中国卒中杂志, 2018, 13(11): 1211-1216. |
| [17] | Magalh？es, J.E. and Rocha-Filho, P.A.S. (2018) Migraine and Cerebrovascular Diseases: Epidemiology, Pathophysiological, and Clinical Considerations. Head-ache, 58, 1277-1286. https://doi.org/10.1111/head.13378 |
| [18] | Kruit, M.C., Van Buchem, M.A., Hofman, P.A., et al. (2004) Migraine as a Risk Factor for Subclinical Brain Lesions. JAMA, 291, 427-34. https://doi.org/10.1001/jama.291.4.427 |
| [19] | Kim, K.W., Macfall, J.R. and Payne, M.E. (2008) Classification of White Matter Lesions on Magnetic Resonance Imaging in Elderly Persons. Biological Psychiatry, 64, 273-280. https://doi.org/10.1016/j.biopsych.2008.03.024 |
| [20] | Zhang, W.Y., Cheng, Z.C., Fu, F.W. and Zhan, Z.X. (2023) Prevalence and Clinical Characteristics of White Matter Hyperintensities in Migraine: A Meta-Analysis. NeuroImage: Clinical, 37, Article ID: 103312.
https://doi.org/10.1016/j.nicl.2023.103312 |
| [21] | Kurth, T., Mohamed, S., Maillard, P., et al. (2011) Headache, Mi-graine, and Structural Brain Lesions and Function: Population Based Epidemiology of Vascular Ageing-MRI Study. BMJ, 342, c7357. https://doi.org/10.1136/bmj.c7357 |
| [22] | Eikermann-Haerter, K. and Huang, S.Y. (2021) White Matter Lesions in Migraine. The American Journal of Pathology, 191, 1955-1962. https://doi.org/10.1016/j.ajpath.2021.02.007 |
| [23] | Swartz, R.H. and Kern, R.Z. (2004) Migraine Is Associated with Magnetic Resonance Imaging White Matter Abnormalities: A Meta-Analysis. Archives of Neurology, 61, 1366-1368. https://doi.org/10.1001/archneur.61.9.1366 |
| [24] | Kruit, M.C., Van Buchem, M.A., Launer, L.J., Terwindt, G.M. and Ferrari, M.D. (2010) Migraine Is Associated with an Increased Risk of Deep White Matter Lesions, Subclinical Pos-terior Circulation Infarcts and Brain Iron Accumulation: The Population-Based MRI CAMERA Study. Cephalalgia, 30, 129-136.
https://doi.org/10.1111/j.1468-2982.2009.01904.x |
| [25] | Palm-Meinders, I.H., Koppen, H., Terwindt, G.M., et al. (2012) Structural Brain Changes in Migraine. JAMA, 308, 1889-1896. https://doi.org/10.1001/jama.2012.14276 |
| [26] | Bashir, A., Lipton, R.B., Ashina, S. and Ashina, M. (2013) Migraine and Structural Changes in the Brain: A Systematic Review and Meta-Analysis. Neurology, 81, 1260-1268. https://doi.org/10.1212/WNL.0b013e3182a6cb32 |
| [27] | Bayram, E., Topcu, Y., Karaoglu, P., et al. (2013) Incidental White Matter Lesions in Children Presenting with Headache. Headache, 53, 970-976. https://doi.org/10.1111/head.12089 |
| [28] | Eidlitz-Markus, T., Zeharia, A., Haimi-Cohen, Y. and Konen, O. (2013) MRI White Matter Lesions in Pediatric Migraine. Cephalalgia, 33, 906-913. https://doi.org/10.1177/0333102413480955 |
| [29] | Mar, S., Kelly, J.E., Isbell, S., et al. (2013) Prevalence of White Matter Lesions and Stroke in Children with Migraine. Neurology, 81, 1387-1391. https://doi.org/10.1212/WNL.0b013e3182a8412e |
| [30] | Androulakis, X.M., Sen, S., Kodumuri, N., et al. (2019) Migraine Age of Onset and Association with Ischemic Stroke in Late Life: 20 Years Follow-Up in ARIC. Headache, 59, 556-566. https://doi.org/10.1111/head.13468 |
| [31] | Gaist, D., Garde, E., Blaabjerg, M., et al. (2016) Migraine with Aura and Risk of Silent Brain Infarcts and White Matter Hyperintensities: An MRI Study. Brain, 139, 2015-2023. https://doi.org/10.1093/brain/aww099 |
| [32] | Monteith, T., Gardener, H., Rundek, T., et al. (2014) Migraine, White Matter Hyperintensities, and Subclinical Brain Infarction in a Diverse Community: The Northern Manhattan Study. Stroke, 45, 1830-1832.
https://doi.org/10.1161/STROKEAHA.114.005447 |
| [33] | Dalkara, T., Nozari, A. and Moskowitz, M.A. (2010) Mi-graine Aura Pathophysiology: The Role of Blood Vessels and Microembolisation. The Lancet Neurology, 9, 309-317. https://doi.org/10.1016/S1474-4422(09)70358-8 |
| [34] | Eikermann-Haerter, K., Negro, A. and Ayata, C. (2013) Spreading Depression and the Clinical Correlates of Migraine. Reviews in the Neurosciences, 2, 353-363. https://doi.org/10.1515/revneuro-2013-0005 |
| [35] | Kurth, T., Chabriat, H. and Bousser, M.G. (2012) Migraine and Stroke: A Complex Association with Clinical Implications. The Lancet Neurology, 11, 92-100. https://doi.org/10.1016/S1474-4422(11)70266-6 |
| [36] | Nozari, A., Dilekoz, E., Sukhotinsky, I., et al. (2010) Mi-croemboli May Link Spreading Depression, Migraine Aura, and Patent Foramen Ovale. Annals of Neurology, 67, 221-229. https://doi.org/10.1002/ana.21871 |
| [37] | Van Den Maagdenberg, A.M., Pizzorusso, T., Kaja, S., et al. (2010) High Cortical Spreading Depression Susceptibility and Migraine-Associated Symptoms in Cav2.1 S218L Mice. Annals of Neurology, 67, 85-98.
https://doi.org/10.1002/ana.21815 |
| [38] | Eikermann-Haerter, K., Lee, J.H., Yalcin, N., et al. (2015) Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice. Stroke, 46, 229-236. https://doi.org/10.1161/STROKEAHA.114.006982 |
| [39] | Chen, S.P. and Ayata, C. (2016) Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports, 20, Article No. 44. https://doi.org/10.1007/s11916-016-0574-8 |
| [40] | Dohmen, C., Sakowitz, O.W., Fabricius, M., et al. (2008) Spreading Depolarizations Occur in Human Ischemic Stroke with High Incidence. Annals of Neurology, 63, 720-728. https://doi.org/10.1002/ana.21390 |
| [41] | Bonetti, P.O., Lerman, L.O. and Lerman, A. (2003) Endothelial Dysfunc-tion: A Marker of Atherosclerotic Risk. Arteriosclerosis, Thrombosis, and Vascular Biology, 23, 168-175. https://doi.org/10.1161/01.ATV.0000051384.43104.FC |
| [42] | Tietjen, G.E. and Khubchandani, J. (2015) Vascular Biomarkers in Migraine. Cephalalgia, 35, 95-117.
https://doi.org/10.1177/0333102414544976 |
| [43] | Hasselblatt, M., Kohler, J., Volles, E. and Hannelore, E. (1999) Simultaneous Monitoring of Endothelin-1 and Vasopressin Plasma Levels in Migraine. NeuroReport, 10, 423-425. https://doi.org/10.1097/00001756-199902050-00039 |
| [44] | Iljazi, A., Ayata, C., Ashina, M. and Hougaard, A. (2018) The Role of Endothelin in the Pathophysiology of Migraine—A Systematic Review. Current Pain and Headache Reports, 22, Article No. 27.
https://doi.org/10.1007/s11916-018-0682-8 |
| [45] | Gormley, P., Anttila, V., Winsvold, B.S., et al. (2016) Me-ta-Analysis of 375,000 Individuals Identifies 38 Susceptibility Loci for Migraine. Nature Genetics, 48, 856-866. https://doi.org/10.1038/ng.3598 |
| [46] | Harriott, A.M. and Barrett, K.M. (2015) Dissecting the Association between Migraine and Stroke. Current Neurology and Neuroscience Reports, 15, Article No. 5. https://doi.org/10.1007/s11910-015-0530-8 |
| [47] | Tietjen, G.E. (2009) Migraine as a Systemic Vasculopathy. Ceph-alalgia, 29, 987-996.
https://doi.org/10.1111/j.1468-2982.2009.01937.x |
| [48] | Butt, J.H., Franzmann, U. and Kruuse, C. (2015) Endothe-lial Function in Migraine with Aura—A Systematic Review. Headache, 55, 35-54. https://doi.org/10.1111/head.12494 |
| [49] | Pezzini, A., Grassi, M., Lodigiani, C., et al. (2011) Predictors of Migraine Subtypes in Young Adults with Ischemic Stroke: The Italian Project on Stroke in Young Adults. Stroke, 42, 17-21.
https://doi.org/10.1161/STROKEAHA.110.592246 |
| [50] | Tietjen, G.E., Khubchandani, J., Herial, N., et al. (2018) Migraine and Vascular Disease Biomarkers: A Population-Based Case-Control Study. Cephalalgia, 38, 511-518. https://doi.org/10.1177/0333102417698936 |
| [51] | Martinez-Sanchez, P., Martinez-Martinez, M., Fuentes, B., et al. (2011) Migraine and Hypercoagulable States in Ischemic Stroke. Cephalalgia, 31, 1609-1617. https://doi.org/10.1177/0333102411427599 |
| [52] | Sarchielli, P., Alberti, A., Coppola, F., et al. (2004) Plate-let-Activating Factor (PAF) in Internal Jugular Venous Blood of Migraine without Aura Patients Assessed during Mi-graine Attacks. Cephalalgia, 24, 623-630.
https://doi.org/10.1111/j.1468-2982.2003.00717.x |
| [53] | Kovacs, K., Herman, F., Filep, J., et al. (1990) Platelet Ag-gregation of Migraineurs during and between Attacks. Cephalalgia, 10, 161-165. https://doi.org/10.1046/j.1468-2982.1990.1004161.x |
| [54] | Cesar, J.M., Garcia-Avello, A., Vecino, A.M., Sastre, J.L. and Alvarez-Cerme？a, J.C. (1995) Increased Levels of Plasma von Willebrand Factor in Migraine Crisis. Acta Neu-rologica Scandinavica, 91, 412-413.
https://doi.org/10.1111/j.1600-0404.1995.tb07030.x |
| [55] | Tietjen, G.E. and Maly, E.F. (2020) Migraine and Is-chemic Stroke in Women. A Narrative Review. Headache, 60, 843-863. https://doi.org/10.1111/head.13796 |
| [56] | Zhang, Y., Parikh, A. and Qian, S. (2017) Migraine and Stroke. Stroke and Vascular Neurology, 2, 160-167.
https://doi.org/10.1136/svn-2017-000077 |
| [57] | Allais, G., Chiarle, G., Sinigaglia, S., et al. (2018) Estrogen, Mi-graine, and Vascular Risk. Neurological Sciences, 39, 11-20. https://doi.org/10.1007/s10072-018-3333-2 |
| [58] | Ong, J.J.Y. and De Felice, M. (2018) Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Ac-tion. Neurotherapeutics, 15, 274-290. https://doi.org/10.1007/s13311-017-0592-1 |
| [59] | Chan, K.Y., Vermeersch, S., De Hoon, J., Villalón, C.M. and MaassenVanDenBrink, A. (2011) Potential Mechanisms of Prospective Antimigraine Drugs: A Focus on Vascular (Side) Effects. Pharmacology & Therapeutics, 129, 332-351.
https://doi.org/10.1016/j.pharmthera.2010.12.001 |
| [60] | De Vries, P., Villalon, C.M., Heiligers, J.P.C. and Saxena, P.R. (1998) Characterization of 5-HT Receptors Mediating Constriction of Porcine Carotid Arteriovenous Anastomoses; Involvement of 5-HT1B/1D and Novel Receptors. British Journal of Pharmacology, 123, 1561-1570. https://doi.org/10.1038/sj.bjp.0701770 |
| [61] | Cortijo, J., Marti-Cabrera, M., Bernabeu, E., et al. (1997) Characteriza-tion of 5-HT Receptors on Human Pulmonary Artery and Vein: Functional and Binding Studies. British Journal of Pharmacology, 122, 1455-1463.
https://doi.org/10.1038/sj.bjp.0701509 |
| [62] | Maassenvandenbrink, A., Reekers, M., Bax, W.A., Ferrari, M.D. and Saxena, P.R. (1998) Coronary Side-Effect Potential of Current and Prospective Antimigraine Drugs. Circulation, 98, 25-30. https://doi.org/10.1161/01.CIR.98.1.25 |
| [63] | Johnston, M.M. and Rapoport, A.M. (2010) Triptans for the Management of Migraine. Drugs, 70, 1505-1518.
https://doi.org/10.2165/11537990-000000000-00000 |
| [64] | Hall, G.C., Brown, M.M., MO, J.P. and MacRae, K.D. (2004) Triptans in Migraine: The Risks of Stroke, Cardiovascular Disease, and Death in Practice. Neurology, 62, 563-568. https://doi.org/10.1212/01.WNL.0000110312.36809.7F |
| [65] | Xu, Z., Li, Y., Tang, S.W., Huang, X.P. and Chen, T. (2015) Current Use of Oral Contraceptives and the Risk of First-Ever Ischemic Stroke: A Meta-Analysis of Observational Studies. Thrombosis Research, 136, 52-60.
https://doi.org/10.1016/j.thromres.2015.04.021 |
| [66] | Peragallo Urrutia, R., Coeytaux, R.R., Mcbroom, A.J., et al. (2013) Risk of Acute Thromboembolic Events with Oral Contraceptive Use: A Systematic Review and Meta-Analysis. Obstetrics & Gynecology, 122, 380-389.
https://doi.org/10.1097/AOG.0b013e3182994c43 |
| [67] | Roach, R.E., Helmerhorst, F.M., Lijfering, W.M., Algra, A. and Dekkers, O.M. (2015) Combined Oral Contraceptives: The Risk of Myocardial Infarction and Ischemic Stroke. Cochrane Database of Systematic Reviews, 2015, CD011054.
https://doi.org/10.1002/14651858.CD011054 |
| [68] | Lidegaard, O. and Kreiner, S. (2002) Contraceptives and Cere-bral Thrombosis: A Five-Year National Case-Control Study. Contraception, 65, 197-205. https://doi.org/10.1016/S0010-7824(01)00306-7 |
| [69] | Champaloux, S.W., Tepper, N.K., Monsour, M., et al. (2017) Use of Combined Hormonal Contraceptives among Women with Migraines and Risk of Ischemic Stroke. American Journal of Obstetrics and Gynecology, 216, 489.E1-489.E7. https://doi.org/10.1016/j.ajog.2016.12.019 |
| [70] | Sacco, S., Merki-Feld, G.S., Kl, A.E., et al. (2018) Effect of Exogenous Estrogens and Progestogens on the Course of Migraine during Reproductive Age: A Consensus Statement by the European Headache Federation (EHF) and the European Soci-ety of Contraception and Reproductive Health (ESCRH). The Journal of Headache and Pain, 19, Article No. 76. https://doi.org/10.1186/s10194-018-0896-5 |
