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锌指蛋白在非小细胞肺癌中的研究进展
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Abstract:
肺癌是一种严重危害人类健康的恶性肿瘤，其发生发展的分子机理仍不清楚。锌指蛋白是一种重要的转录因子，对基因的表达具有重要的调节作用。研究发现，锌指蛋白在肺癌中发挥着类似于原癌和抑癌基因的功能，是一种潜在的肿瘤基因治疗靶点。由于小细胞肺癌的发生发展机制复杂，至今尚未完全揭示。锌指蛋白已被证明在包括非小细胞肺癌在内的许多癌症中起着关键作用。本文就锌指蛋白与非小细胞肺癌的关系做一综述。我们将讨论锌指蛋白的组成和类型及其在非小细胞肺癌中的作用机制。
Lung cancer is a kind of malignant tumor that seriously endangers human health, and the molecu-lar mechanisms have not been elucidated. Zinc finger proteins are a class of transcription factors with finger-like domains that play an important role in gene regulation. Studies have shown that zinc finger proteins are widely involved in the occurrence of lung cancer, and their effect is similar to that of oncogenes or tumor suppressor genes, which is expected to become a new target for gene therapy of lung cancer. Due to the complex mechanism of small cell lung cancer, it has not been fully revealed. Zinc-finger proteins have been shown to play a critical role in many cancers, including small-cell lung cancer. This paper summarizes the relationship between zinc finger protein and non-small cell lung cancer. We will discuss the composition and type of zinc finger proteins and their mechanism of action in non-small cell lung cancer.
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