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经动脉化疗栓塞(TACE)联合经动脉灌注化疗(HAIC)对比单纯TACE治疗不可切除肝癌的疗效及安全性
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Abstract:
目的：比较TACE联合HAIC与单纯TACE方案治疗不可切除肝细胞癌的疗效及安全性。方法：该项研究为单中心回顾性研究，选取了2020年8月至2021年8月在重庆医科大学附属第二医院接受了TACE + HAIC或单纯TACE治疗的HCC患者共156人。分为TACE + HAIC方案组80人，单纯TACE方案组76人。结果：两组均无患者达到CR，TACE + HAIC组明显高于TACE组的客观缓解率(ORR) (46.3% vs 25.0%, p = 0.006)。而两组患者的DCR无明显差异(TACE + HIAC: 92.6% vs TACE: 85.5%, p = 0.162)。对两组的ORR与DCR之间进行了单因素logistic回归，结果显示ORR (OR: 0.387, 95%CI: 0.196~0.765, p = 0.006)，DCR (OR: 0.479, 95%CI: 0.168~1.368, p = 0.169)。以及多因素logistic回归分析显示ORR (OR: 0.291, 95%CI: 0.126~0.674, p = 0.004)，DCR (OR: 0.550, 95%CI: 0.161~1.876, p = 0.339)。结论：TACE + HAIC治疗晚期不可切除肝癌的疗效明显优于单纯TACE治疗。
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