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白细胞介素-22与结肠疾病关系的研究进展
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Abstract:
白细胞介素22 (IL-22)属IL-10家族中的一员，是一种新型的免疫分子，由多种免疫细胞介导产生，但主要靶细胞为非造血细胞，如上皮细胞和基质细胞。IL-22不仅在抗菌免疫及肠道损伤修复中至关重要，同时也在组织损伤和慢性炎症中扮演着重要的角色。越来越多的研究发现，IL-22与多种结肠疾病之间存在着密切的关联，包括溃疡性结肠炎、克罗恩病、肠易激综合征、肠结核、结肠癌等。本文主要讨论有关IL-22的结构、功能等，特别是IL-22在结肠疾病中的复杂作用。
Interleukin 22 (IL-22), a member of the IL-10 family, is a novel immune molecule that is produced mediated by a variety of immune cells, but the main target cells are non-hematopoietic cells, such as epithelial cells and fibroblasts. IL-22 is not only essential in antimicrobial immunity and intesti-nal injury repair, but also plays an important role in tissue damage and chronic inflammation. An increasing number of studies have found a close association between IL-22 and a variety of colon diseases, including ulcerative colitis, Crohn’s disease, irritable bowel syndrome, intestinal tubercu-losis, and colon cancer. This article discusses about the structure and function of IL-22, especially the complex role of IL-22 in colon diseases.
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