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铜死亡相关基因在癌症中的表达及治疗
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Abstract:
铜依赖性死亡是一种新型的导致细胞死亡的机制，研究中主要鉴定10种铜死亡相关基因(cuproptosis-related genes, CRGs)的表达水平发生异常改变，可能是肿瘤发生的驱动因素之一。目前CRGs在肿瘤中的作用尚未阐明，但在某些对CRGs的研究中，发现CRGs是在肿瘤的发生、发展过程中发挥关键作用的一类基因，它们参与了肿瘤细胞增殖、凋亡、侵袭、转移等多个生物学过程，帮助我们理解了肿瘤的分子机制，为癌症的治疗和预后预测提供参考。此外，CRGs的表达模式和水平在癌症中也会有所不同。CRGs的表达水平可以被用来预测肿瘤的治疗效果和预后。对于某些癌症来说，高表达的CRGs可能预示着肿瘤对特定治疗方法的敏感性，而低表达的CRGs则可能提示治疗效果较差。并且，CRGs的表达水平也可以用于预测患者的生存期和疾病复发率等临床结果。本综述揭示了CRGs在乳腺癌、黑色素瘤、肾癌等各种癌症中的基因组改变和临床特征。
Copper-dependent death is a novel mechanism leading to cell death. In this study, we identified 10 cuproptosis-related genes (CRGs) with abnormal expression levels, which may be one of the driving factors of tumorigenesis. At present, the role of CRGs in tumor has not been elucidated, but in some research on CRGs, it is found that CRGs is a kind of gene that plays a key role in the development of tumor; they are involved in many biological processes, such as cell proliferation, apoptosis, invasion and metastasis, which help us to understand the molecular mechanism of cancer and provide ref-erences for cancer therapy and prognosis prediction. In addition, the expression patterns and levels of CRGs vary in cancer. The expression level of CRGs can be used to predict the therapeutic effect and prognosis of tumor. For some cancers, high expression of CRGs may indicate tumor sensitivity to specific therapies, whereas low expression of CRGs may indicate poor therapeutic efficacy. Further-more, the expression level of CRGs can also be used to predict clinical outcomes such as patient sur-vival and disease recurrence. This review reveals the genomic alterations and clinical features of CRGs in breast cancer, melanoma, renal cell carcinoma and other cancers.
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