Background:Adequate selection of a prospective whole blood donor protects his health
and safety of the recipient. Objectives: The main objective of this
study was to determine the haematology parameters of apparently healthy
prospective whole blood donors. Participants and Methods: This was a hospital based prospective
study carried out from August to October 2020 at the blood transfusion
unit of the Lagos State University Teaching Hospital (LASUTH), Ikeja, Nigeria.A structured pretested questionnaire was used for data collection. The
socio demographic status and the haematology parameters of apparently healthy
prospective whole blood donors who tested negative for HIV, hepatitis B and C
markers were captured. Obtained data were analysed with the statistical package
for the social scientist software version 20. Results: One hundred male (97.1%) and three female (2.9%) apparently healthy
prospective whole blood donors were studied. The median age of study subjects
was 30 years. Obtained median haematology parameter values were 13g/dl,
40%, 4.9/nl and 203.9/nl for haemoglobin concentration, haematocrit, total
white cell and platelet counts respectively. The median values for the mean
corpuscular haemoglobin concentration (MCHC), mean corpuscular haemoglobin
(MCH) and mean corpuscular volume (MCV) of participants were 32.6g/dl,27.7pg and
85.7
References
[1]
WHO (2012). https://www.who.int/health-topics/blood-transfusion-safety#tab=tab_1
[2]
Joint UKBTS/NIBSC Professional Advisory Committee’s (JPAC) (2005) Guidelines for the Blood Transfusion Services in the United Kingdom. 7th Edition. https://www.transfusionguidelines.org.uk
[3]
Lotfi, R.A. (2005) Non-Invasive Strategy for Screening Prospective Blood Donors for Anaemia. Transfusion, 45, 1585-1592. https://doi.org/10.1111/j.1537-2995.2005.00574.x
[4]
Boulton, F. (2008) Evidence-Based Criteria for the Care and Selection of Blood Donors, with Some Comments on the Relationship to Blood Supply and Emphasis on the Management of Donation-Induced Iron Depletion. Transfusion Medicine, 18, 13-27. https://doi.org/10.1111/j.1365-3148.2007.00818.x
[5]
Eder, A. (2010) Evidence-Based Selection Criteria to Protect Blood Donors. Journal of Clinical Apheresis, 25, 331-337. https://doi.org/10.1002/jca.20257
[6]
Pan American Health Organisation (2009) Eligibility for Blood Donation: Recommendations for Education and Selection of Prospective Blood Donors. PAHO, Washington DC. http://new.paho.org/hq/dmdocuments/2009/EligiBlood09EN.pdf
[7]
Brittenham, G.M. (2011) Iron Deficiency in Whole Blood Donors. Transfusion, 51, 458-461. https://doi.org/10.1111/j.1537-2995.2011.03062.x
[8]
Okoroiwu, H.U., Okafor, I.M., Asemota, E.A. and Okpokam, D.C. (2018) Seroprevalence of Transfusion-Transmissible Infections (HBV, HCV, Syphilis and HIV) among Prospective Blood Donors in a Tertiary Health Care Facility in Calabar, Nigeria: An Eleven Years Evaluation. BMC Public Health, 18, Article No. 645. https://doi.org/10.1186/s12889-018-5555-x
[9]
Ogar, C.O., Okpokam, D.C., Okoroiwu, H.U. and Okafor, I.M. (2021) Comparative Analysis of Hematological Parameters of First-Time and Repeat Blood Donors: Experience of a Blood Bank in Southern Nigeria. Hematology, Transfusion and Cell Therapy, 44, 512-518. https://doi.org/10.1016/j.htct.2021.06.013
[10]
Osuji, A.I., Agbakoba, R.N., Ifeanyichukwu, M.O., Obi, E. and Njab, J. (2019) Sociodemographic Characteristics, Hematological Parameters and Absolute CD4 Counts of Healthy Blood Donors at Two Teaching Hospitals in Nigeria. Journal of Blood Disorders and Transfusion, 10, 430.
[11]
Bochen, K., Krasowska, A., Milariuk, S., Kulczynska, M., Pryskupa, A. and Dzida, G. (2011) Erythrocyte Sedimentation Rate—An Old Marker with New Applications. Journal of Pre-Clinical and Clinical Research, 5, 50-55.
[12]
Kone, B., Maiga, M., Baya, B., Sarro, Y.D.S., Coulibaly, N., Kone, A., et al. (2017) Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults. Journal of Blood and Lymph, 7, Article No. 154.
[13]
World Health Organization (2012) Blood Donor Selection. Guidelines on Assessing Donor Suitability for Blood Donation. https://www.who.int
[14]
Ugwu, A.O., Madu, A.J., Efobi, C.C. and Ibegbulam, O.G. (2018) Pattern of Blood Donation and Characteristics of Blood Donors in Enugu, Southeast Nigeria. Nigerian Journal of Clinical Practice, 21, 1438-1443.
[15]
Ayemoba, O., Hussain, N., Umar, T., Ajemba-Life, A., Kene, T. and Edom, U. (2019) Establishment of Reference Values for Selected Haematological Parameters in Young Adult Nigerians. PLOS ONE, 14, e0213925. https://doi.org/10.1371/journal.pone.0213925
[16]
Emeribe, A.O., Ejele, A.O., Attai, E.E. and Usanga, E.A. (1993) Blood Donation and Patterns of Use in Southeastern Nigeria. Transfusion, 33, 330-332. https://doi.org/10.1046/j.1537-2995.1993.33493242641.x
[17]
Eller, L.A., Eller, M.A., Ouma, B., Kataaha, P., Kyabaggu, D., Tumusiime, R., et al. (2008) Reference Intervals in Healthy Adult Ugandan Blood Donors and Their Impact on Conducting International Vaccine Trials. PLOS ONE, 3, e3919. https://doi.org/10.1371/journal.pone.0003919
[18]
Berhanu, S., Abebaw, S. and Digissie, A. (2016) Transfusion Transmissible Infections among Blood Donors at Debre Tabor Blood Bank, North West Ethiopia: A Three Years Retrospective Study. Health Care Current Reviews, 6, Article ID: 1000236.
[19]
Adu-poku, F., Agboli, E. and Tarkang, E.E. (2020) Seroprevalence of Transfusion Transmissible Infections among Blood Donors in the Hohoe Municipality Hospital, Ghana: 2015-2016: A Retrospective Hospital-Based Cross-Sectional Study. PAMJ— Clinical Medicine, 2, Article No. 12.
[20]
Jany, A., Dienta, S., Leducq, V., Le Hingrat, Q., Cisse, M. and Diaura, A.B. (2019) Seroprevalence and Risk Factors for HIV, HCV, HBV, and Syphilis among Blood Donors in Mali. BMC Infectious Diseases, 19, Article No. 1064. https://doi.org/10.1186/s12879-019-4699-3
[21]
Abud, A.I., Bashein, A.M. and Msalati, A.A. (2009) Investigating the Importance of Haemoglobin Measurement for Selection of Blood Donors in Libya. Libyan Journal of Medicine, 4, 137-139. https://doi.org/10.3402/ljm.v4i4.4837
[22]
Jeremiah, Z.A., Umoh, R.E. and Adias, T.C. (2011) Subclinical Leukopenia in a Cross Section of Nigerian Blood Donors. Journal of Blood Medicine, 2, 79-85. https://doi.org/10.2147/JBM.S16214
[23]
Lugos, M.D., Okoh, J.B., Polit, U.Y., Vwamdem, N.Y., Ofojekwu, M.J.N., Nnanna, O.U., et al. (2019) Some Hematologic Parameters of Blood Donors at the National Blood Transfusion Service (NBTS), Jos, Nigeria. Journal of Blood Disorders and Transfusion, 10, Article ID: 1000416. https://doi.org/10.4172/2155-9864.1000416
[24]
Constantine, N.T., Saville, R.D. and Dax, E.M. (2005) Retroviral Testing and Quality Assurance: Essentials for Laboratory Diagnosis. MedMira Laboratories, Halifax, 133-151.
[25]
Fasola, F.A., Otegbayo, J.A., Abjah, U.M. and Ola, S.O. (2009) Haematological Parameters in Nigerians with Acute Viral Hepatitis. The Nigerian Journal of Gastroenterology and Hepatology, 1, 27-31.
[26]
Ajugwo, A.O., Ukaji, D.C., Erhabor, T.A. and Adias, T.C. (2015) Some Haematological Parameters of Symptomatic and Asymptomatic Hepatitis B Positive Patients Attending a Nigerian Tertiary Hospital. British Journal of Medicine and Medical Research, 7, 219-223. https://doi.org/10.9734/BJMMR/2015/15491
[27]
Akintunde, E.O., Shokunbi, W.A. and Adekunle, C.O. (1995) Leucocyte Count, Platelet Count and Erythrocyte Sedimentation Rate in Pulmonary Tuberculosis. The African Journal of Medicine and Medical Sciences, 24, 131-134.
[28]
Breckenridge, M.A. and Okpanachi, E. (1976) The Erythrocyte Sedimentation Rate in Healthy North Nigerian University Students. The African Journal of Medicine and Medical Sciences, 5, 221-227.
[29]
Obi, G.O. (1984) Normal Values for Haemoglobin, Packed Cell Volume and Erythrocyte Sedimentation Rate in Healthy Nigerian Adults. The African Journal of Medicine and Medical Sciences, 13, 1-6.
[30]
Beutler, E. and West, C. (2005) Haematologic Differences between African-Americans and Whites: The Roles of Iron Deficiency and Alpha-Thalassemia and Hemoglobin Levels and Mean Corpuscular Volume. Blood, 106, 740-745. https://doi.org/10.1182/blood-2005-02-0713