Background:Meningitis is a major public health problem needing
timely diagnosis, appropriate treatment, prevention and control. Despite the
advances in diagnosis and treatment of
infectious diseases, meningitis is still considered as an important cause of
mortality and morbidity, especially in the paediatric population of
lower income countries such as the Democratic Republic of the Congo (DR Congo).
In this study, we aimed to analyse the fatality aspect of suspected meningitis
among children under five years. Materials and Methods:A prospective, descriptive study was carried out in the Paediatrics departments of four hospitals in the
South-Kivu province in the Eastern part of the DR Congo from April 2021 to
March 2022. Of the 1386 children enrolled, 251 children were suspected of
meningitis. This study captures data generated in the framework of routine
medical practice, which includes medical history, clinical diagnosis and
results of locally conducted laboratory tests. Results:Throughout the study period, a total of 251 patients
(18.1%) aged 1 month to 59 months with suspected meningitis were recruited out
of 1386 children hospitalized in the
References
[1]
World Health Organisation (2021) Defeating Meningitis by 2030: A Global Road Map. Organisation Mondiale de la Santé, Genève.
https://apps.who.int/iris/handle/10665/342010
[2]
Organisation mondiale de la Sante (2015) Contrôle des épidémies de méningite en Afrique.
[3]
Bourillon, A., Benoist, G., Chabrol, B., Cheron, G. and Grimprel, E. (2020) Pédiatrie Pour le Praticien. 7e edition.
[4]
Abbafati, C., et al. (2020) Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990-2019: A Systematic Analysis for the Global Burden of Disease Study 2019. The Lancet, 396, 1204-1222.
[5]
águeda, S., Campos, T. and Maia, A. (2013) Prediction of Bacterial Meningitis Based on Cerebrospinal Fluid Pleocytosis in Children. The Brazilian Journal of Infectious Diseases, 17, 401-404. https://doi.org/10.1016/j.bjid.2012.12.002
[6]
Chaudhary, S., Bhatta, N.K., Lamsal, M., Chaudhari, R.K. and Khanal, B. (2018) Serum Procalcitonin in Bacterial & Non-Bacterial Meningitis in Children. BMC Pediatrics, 18, Article No. 342. https://doi.org/10.1186/s12887-018-1314-5
[7]
Tilahun, T., et al. (2018) Clinical Outcomes and Risk Factors of Meningitis among Children in Referral Hospital, Ethiopia, 2016: A Retrospective Chart Review. Ethiopian Journal of Health Sciences, 28, 563-570.
[8]
Peltola, H. and Roine, I. (2009) Improving the Outcomes in Children with Bacterial Meningitis. Current Opinion in Infectious Diseases, 22, 250-255.
https://doi.org/10.1097/QCO.0b013e328329c47a
[9]
Bourrillon, A., et al. (2011) Pediatrie Pour les Praticiens. 6e Edition, Elsevier Masson SAS, Paris.
[10]
Berangi, Z., Karami, M., Mohammadi, Y., Nazarzadeh, M. and Zahraei, S.M. (2019) Epidemiological Profile of Meningitis in Iran before Pentavalent Vaccine Introduction. BMC Pediatrics, 19, Article No. 370.
https://doi.org/10.1186/s12887-019-1741-y
[11]
Rossi, P.G., Stanghellini, E., Curtale, F. and Borgia, P. (2009) Incidence of Bacterial Meningitis (2001-2005) in Lazio, Italy: The Results of a Integrated Surveillance System. BMC Infectious Diseases, 9, Article No. 13.
https://doi.org/10.1186/1471-2334-9-13
[12]
Kim, K.S. (2010) Acute Bacterial Meningitis in Infants and Children. The Lancet Infectious Diseases, 10, 32-42. https://doi.org/10.1016/S1473-3099(09)70306-8
[13]
Organisation mondiale de la Sante (2021) Cadre pour la mise en oeuvre de la strategie pour vaincre la meningite d’ici2030 dans la region africaine de l’OMS.
[14]
Boni-cisse, C., et al. (2019) Etiology of Bacterial Meningitis among Children < 5 Years Old in Côte d’Ivoire: Findings of Hospital-Based Surveillance before and after Pneumococcal Conjugate Vaccine Introduction. Clinical Infectious Diseases, 69, S114-S120. https://doi.org/10.1093/cid/ciz475
[15]
Mazamay, S., et al. (2021) An Overview of Bacterial Meningitis Epidemics in Africa from 1928 to 2018 with a Focus on Epidemics “Outside-the-Belt”. BMC Infectious Diseases, 21, Article No. 1027. https://doi.org/10.1186/s12879-021-06724-1
[16]
Mushagalusa, B., Babunga, M., Badibanga, M., Karazo, N. and Riziki, M. (2015) Bacterial Meningitis in Children in Lwiro (South Kivu DRC). International Journal of Innovation and Applied Studies, 11, 204-206.
[17]
Birindwa, M., Jeanniere, M. andersson, R., Mindja, A. and Nordén, R. (2020) Decreased Number of Hospitalized Children with Severe Acute Lower Respiratory Infection after Introduction of the Pneumococcal Conjugate Vaccine in the Eastern Democratic Republic of the Congo. The Pan African Medical Journal, 37, Article No. 211. https://doi.org/10.11604/pamj.2020.37.211.22589
[18]
de la Sante, M. (2014) Deuxième enquête démographique et de santé (eds-rdc ii 2013-2014). MPSMRM, MSP et ICF International, Rockville.
[19]
Organisation Mondiale de la Santé (2019) Procédures opérationnelles Standard pour la surveillance, la préparation et la riposte aux épidémies de méningite en Afrique. Brazzaville. https://creativecommons.org/licenses/by-nc-sa/3.0/igo
[20]
W.H. Organization (2009) Standard Operating Procedures for Enhanced Meningitis Surveillance in Africa.
[21]
Agossou, J., et al. (2016) Serotypes of Bacteria Encountered in Childhood Purulent Meningitis in Children in Parakou (Benin) in 2011. Open Journal of Pediatrics, 6, 109-119. http://www.scirp.org/journal/ojped
https://doi.org/10.4236/ojped.2016.61017
[22]
Awulachew, E., Diriba, K. and Awoke, N. (2020) Bacterial Isolates from CSF Sample and Their Antimicrobial Resistance Patters in among Under-Five Children Suspected for Meningitis in Dilla University Referral Hospital.
https://doi.org/10.1101/2020.06.01.127456
[23]
Tekpa, G., Gbangba Ngai, E., Yangatimbi, E., Kitakossi, F., Mossoro-kpinde, C. and Mbelesso, P. (2020) Aspects cliniques et bactériologiques des méningites purulentes en zone rurale centrafricaine. Revue Malienne d’Infectiologie et de Microbiologie, 15, 44-53. https://doi.org/10.53597/remim.v15i1.1565
[24]
Al-ojali, S.M., Al-fituri, S.M., Ramadan, M.A.G., Walid, M., Ramadan, A. and Busba, A.O. (2022) Bacterial Meningitis among Children and Antibiotic Sensitivity Patterns in the East of Libya. International Journal of Multidisciplinary Research and Publications, 4, 101-105.
[25]
Valerie, H. (2021) Baseline Incidence of Meningitis, Malaria, Mortality and Other Health Outcomes in Infants and Young Sub-Saharan African Children Prior to the Introduction of the RTS, S/AS01E Malaria Vaccine. Malaria Journal, 20, Article No. 197.
[26]
Iregbu, K.C. and Abdullahi, N. (2015) Profiles of Acute Bacterial Meningitis Isolates in Children in National Hospital, Abuja. Nigerian Medical Journal, 56, 297-300.
https://doi.org/10.4103/0300-1652.169749
[27]
Ingersoll, M.A. (2017) Sex Differences Shape the Response to Infectious Diseases. PLOS Pathogens, 13, e1006688.
http://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006688&type=printable
[28]
Rahimi, B.A., Ishaq, N., Mudaser, G.M. and Taylor, W.R. (2022) Outcome of Acute Bacterial Meningitis among Children in Kandahar, Afghanistan: A Prospective Observational Cohort Study. PLOS ONE, 17, e0265487.
https://doi.org/10.1371/journal.pone.0265487
[29]
Mantese, O., Hirano, J., Santos, I. and Silva, V.M. (2002) Etiological Profile of Bacterial Meningitis in Children. Jornal de Pediatria, 78, 467-474.
https://doi.org/10.2223/JPED.901
[30]
Diarra, F. (2012) Facteur pronostic et dévenir des enfants atteints de méningites dans le département de Pédiatrie du CHU Gabriel Toure de 2009 à 2010.
[31]
Shiferaw, Z., et al. (2019) Clinical Outcome of Meningitis and Its Risk Factors among Children Admitted in Debre Markos Referral Hospital Pediatric Ward, Northwest Ethiopia, 2019.
[32]
Basse, I., et al. (2020) Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal. International Journal of Infectious Diseases and Therapy, 5, 127-130. https://doi.org/10.11648/j.ijidt.20200504.14
[33]
Ciofi, M., Esposito, S., Parola, L., Ravà, L., Gargantini, G. and Longhi, R. (2014) In-Hospital Management of Children with Bacterial Meningitis in Italy. Italian Journal of Pediatrics, 40, 87.
[34]
Thomas, Y., Adehossi, é., Abboud, P., Blaizot, R. and Bleibtreu, A. (2022) Maladies Infectieuses Tropicales. 3rd Edition, Alinéa Plus, Paris.
https://www.infectiologie.com
[35]
Maiga, B. and Sacko, K. (2019) Méningites Bactériennes chez l’Enfant au Service de Pédiatrie du CHU Gabriel Toure. Health Sciences and Disease, 20, 63-64.
[36]
Thigpen, M., et al. (2011) Bacterial Meningitis in the United States, 1998-2007. The New England Journal of Medicine, 364, 2016-2041.
https://doi.org/10.1056/NEJMoa1005384
[37]
Thabet, F., et al. (2007) Pneumococcal Meningitis Mortality in Children. Prognostic Factors in a Series of 73 Cases. Archives de Pédiatrie, 14, 334-337.
[38]
Figueiredo, A., et al. (2018) Acute Community-Acquired Bacterial Meningitis. Neurologic Clinics, 36, 809-820. https://doi.org/10.1016/j.ncl.2018.06.007
