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壁层上皮细胞与肾小球疾病
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Abstract:
肾小球内皮细胞、系膜细胞、足细胞和壁层上皮细胞(parietal epithelial cells, PECs)作为肾小球的固有细胞，在肾小球疾病的发病机制中发挥着重要的作用。近年来，随着对PECs研究的不断深入，发现了其在正常生理功能和病理过程中可活化，并在肾小球新月体和球性硬化的形成和转归过程中发挥着重要作用。本文将对PECs在维持肾小球正常生理功能及在肾小球疾病发生发展过程中的作用及相关信号通路和信号分子作一综述。
Glomerular endothelial cells, mesangial cells, podocytes and parietal epithelial cells (PECs) play an important role in the pathogenesis of glomerular disease as intrinsic cells of the glomerular. In recent years, with the deepening of the research on PECs, it has been found that PECs can be activated in normal physiological functions and pathological processes, and play an important role in the formation and progression of glomerular crescents and spherical sclerosis. In this review, we will review the role of PECs in maintaining normal physiological functions of glomerulus and in the occurrence and development of glomerular diseases as well as the related signaling pathways and molecules.
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