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循环肿瘤细胞在进展期胃癌中的研究进展
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Abstract:
胃癌(GC)是最常见的消化道恶性肿瘤之一，指导GC的个性化治疗是研究的重点。临床上用于肿瘤复发监测的主要手段是肿瘤标志物检查和影像学检查。肿瘤标志物检查不具有特异性，而影像学检查的主要问题在于时间滞后，当CT检查提示异常时，通常意味着复发、转移已达到一定严重程度了。而循环肿瘤细胞(Circulating Tumor Cell, CTC)可以确定肿瘤的动态变化。作为一种无创的辅助诊断方法，CTC可以提供有关疾病进展的诊断和预后信息。本文主要描述了CTC在GC的发生、发展和治疗效果中的应用价值。
Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract, and guiding the personalized treatment of gastric cancer is the focus of research. The main means used clinically for tumor recurrence monitoring are tumor marker examination and imaging examination. Tumor markers are not specific, and the main problem with imaging is time lag, and when CT shows ab-normalities, it usually means that recurrence and metastasis have reached a certain severity. Cir-culating tumor cells (CTCs) can determine the dynamics of tumors. As a non-invasive auxiliary di-agnostic method, CTC can provide diagnostic and prognostic information about disease progression. CTC includes circulating tumor cells, circulating tumor DNA, circulating tumor RNA and cytokines. This article mainly describes the classification of CTC and its application value in the occurrence, development and treatment effect of GC.
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