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上皮样滋养细胞肿瘤的研究进展
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Abstract:
上皮样滋养细胞肿瘤(epithelioid trophoblastic tumor, ETT)起源于绒毛膜型中间型滋养细胞，是一类罕见的滋养细胞肿瘤。ETT生长缓慢，临床表现缺乏特异性，临床诊断困难，易误诊及延迟诊断。手术是其主要的确诊及治疗方式，术后辅助化疗的指征及效果仍有争议，目前认为具有高危因素者应辅助化疗。对于晚期及难治性病例可考虑联合免疫治疗等多种治疗方式。目前对于ETT的认识有限，本文通过回顾国内外文献，对ETT的研究进展进行综述。
Epithelioid trophoblastic tumor (ETT) is a rare type of malignant trophoblastic tumor that origi-nates from intermediate trophoblastic cells of the choroidal type. ETT has a slow growth rate and a lack of specificity in clinical presentation, making it difficult to diagnose. Surgery is the main diag-nostic and therapeutic modality. The indications and effects of adjuvant chemotherapy after sur-gery are still controversial, but it is currently believed that adjuvant chemotherapy should be given to those with high-risk factors. For advanced and refractory cases, a combination of immunotherapy and other treatment modalities can be considered. The current understanding of ETT is limited, and this article reviews the research progress of ETT by reviewing the domestic and international literature.
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