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基于肠道菌群探讨中医药治疗失眠研究进展
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Abstract:
睡眠障碍是由于各种原因导致人类睡眠和觉醒机制异常，从而出现睡眠量不正常以及睡眠中异常行为的疾病，其中最为常见的是失眠症。自2020年以来，新冠肺炎大流行相关焦虑进一步加剧了睡眠问题。越来越多研究表明肠道菌群在调节睡眠方面发挥着重要作用。反过来，睡眠障碍通过脑–肠道–微生物区轴(BGMA)影响肠道菌群的组成、多样性和功能。本文从中医理论及临床实践出发，基于肠道菌群理论，对近年来中药单体、复方及针灸治疗失眠相关中医体质的作用机制进行梳理和总结，以期为中医药治疗失眠研究提供新的思路。
Sleep disorder is a disease that leads to abnormal sleep and awakening mechanism due to various reasons, resulting in abnormal amount of sleep and abnormal behavior during sleep, of which insomnia is the most common. Since 2020, COVID-19’s pandemic-related anxiety has further exacerbated sleep problems. More and more studies have shown that intestinal flora plays an important role in regulating sleep. In turn, sleep disorders affect the composition, diversity and function of intestinal flora through the brain-gut-microbial axis (BGMA). Based on the theory of traditional Chinese medicine and clinical practice, and based on the theory of intestinal flora, this paper combs and summarizes the mechanism of traditional Chinese medicine monomer, compound prescription and acupuncture in the treatment of insomnia in recent years. in order to provide new ideas for the treatment of insomnia with traditional Chinese medicine.
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