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特发性震颤非运动症状的研究进展
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Abstract:
特发性震颤是以动作性震颤为主要表现的运动障碍性疾病，包括运动症状和非运动症状。特发性震颤通常是家族性的，具有典型的常染色体显性模式，并且在65岁以上的老年人群中最常见。近年来，关于特发性震颤的研究越来越多地表明，其非运动症状是运动症状的伴随特征，甚至是早于运动症状的原发疾病症状，随着疾病进展逐渐加重，并对患者生活质量造成不良影响。非运动症状主要包括认知障碍、精神障碍、睡眠障碍和感觉障碍(如听力、嗅觉异常)等，正确认识特发性震颤非运动症状的机制、临床特点及诊治有助于指导患者改变生活方式从而提高患者生活质量。本文就特发性震颤非运动症状的临床表现、病理生理及研究进展等方面作一综述。
Essential tremor, including both motor and non-motor symptoms, is a movement disorder with ki-netic tremor as the main manifestation. ET is usually familial with a typical autosomal dominant pattern, and it is mostly seen in the elderly population over 65 years of age. In recent years, studies on essential tremor have increasingly shown that its non-motor symptoms are concomitant with or even preceding the motor symptoms of primary diseases. Non-motor symptoms can progressively become more severe as the disease progresses and adversely affect the patient’s quality of life. Non-motor symptoms mainly include cognitive impairment, psychiatric disorders, sleep disorders and sensory disorders (e.g. hearing and smell abnormalities). Proper understanding of the mecha-nisms, clinical features and treatment of non-motor symptoms of essential tremor can help profes-sionals guide patients to change their lifestyles to improve their quality of life. This article reviews the clinical symptoms, pathophysiology, and research progress of non-motor symptoms of essential tremor.
| [1] | Louis, E.D. (2016) Non-Motor Symptoms in Essential Tremor: A Review of the Current Data and State of the Field. Parkinsonism & Related Disorders, 22, S115-S118. https://doi.org/10.1016/j.parkreldis.2015.08.034 |
| [2] | Janicki, S.C., Cosentino, S. and Louis, E.D. (2013) The Cognitive Side of Essential Tremor: What Are the Therapeutic Implica-tions? Therapeutic Advances in Neurological Disorders, 6, 353-368.
https://doi.org/10.1177/1756285613489591 |
| [3] | Lorenz, D., Schwieger, D., Moises, H. and Deuschl, G. (2006) Quality of Life and Personality in Essential Tremor Patients. Movement Disorders, 21, 1114-1118. https://doi.org/10.1002/mds.20884 |
| [4] | Benito-León, J., Louis, E.D. and Bermejo-Pareja, F. (2006) Popula-tion-Based Case-Control Study of Cognitive Function in Essential Tremor. Neurology, 66, 69-74. https://doi.org/10.1212/01.wnl.0000192393.05850.ec |
| [5] | Thawani, S.P., Schupf, N. and Louis, E.D. (2009) Es-sential Tremor Is Associated with Dementia: Prospective Population-Based Study in New York. Neurology, 73, 621-625. https://doi.org/10.1212/WNL.0b013e3181b389f1 |
| [6] | Gasparini, M., Bonifati, V., Fabrizio, E., Fabbrini, G., Brusa, L., Lenzi, G.L. and Meco, G. (2001) Frontal Lobe Dysfunction in Essential Tremor: A Preliminary Study. Journal of Neurology, 248, 399-402.
https://doi.org/10.1007/s004150170181 |
| [7] | Tr？ster, A.I., Woods, S.P., Fields, J.A., Lyons, K.E., Pahwa, R., Higginson, C.I. and Koller, W.C. (2002) Neuropsychological Deficits in Essential Tremor: An Expression of Cerebel-lo-Thalamo-Cortical Pathophysiology? European Journal of Neurology, 9, 143-151. https://doi.org/10.1046/j.1468-1331.2002.00341.x |
| [8] | Sahin, H.A., Terzi, M., U？ak, S., Yapici, O., Basoglu, T. and Onar, M. (2006) Frontal Functions in Young Patients with Essential Tremor: A Case Comparison Study. The Jour-nal of Neuropsychiatry and Clinical Neurosciences, 18, 64-72. https://doi.org/10.1176/jnp.18.1.64 |
| [9] | Bermejo-Pareja, F., Louis, E.D. and Benito-León, J. (2007) Risk of Inci-dent Dementia in Essential Tremor: A Population-Based Study. Movement Disorders, 22, 1573-1580. https://doi.org/10.1002/mds.21553 |
| [10] | Shill, H.A., Hentz, J.G., Jacobson, S.A., Belden, C., Sabbagh, M.N., Beach, T.G., Driver-Dunckley, E. and Adler, C.H. (2014) Essential Tremor in the Elderly and Risk for Dementia. Jour-nal of Neurodegenerative Diseases, 2014, Article ID: 328765. https://doi.org/10.1155/2014/328765 |
| [11] | Louis, E.D., Benito-León, J., Vega-Quiroga, S. and Bermejo-Pareja, F., the Neurological Disorders in Central Spain (NEDICES) Study Group (2010) Faster Rate of Cognitive Decline in Essential Tremor Cases than Controls: A Prospective Study. European Journal of Neurology, 17, 1291-1297.
https://doi.org/10.1111/j.1468-1331.2010.03122.x |
| [12] | Pan, J.J., Lee, M., Honig, L.S., Vonsattel, J.P., Faust, P.L. and Louis, E.D. (2014) Alzheimer’s-Related Changes in Non-Demented Essential Tremor Patients vs. Controls: Links between Tau and Tremor? Parkinsonism & Related Disorders, 20, 655-658. https://doi.org/10.1016/j.parkreldis.2014.03.003 |
| [13] | Radler, K.H., Zdrodowska, M.A., Dowd, H., Cersonsky, T.E.K., Huey, E.D., Cosentino, S. and Louis, E.D. (2020) Rate of Progression from Mild Cognitive Impairment to De-mentia in an Essential Tremor Cohort: A Prospective, Longitudinal Study. Parkinsonism & Related Disorders, 74, 38-42. https://doi.org/10.1016/j.parkreldis.2020.04.008 |
| [14] | Peterson, A., Chapman, S., Iglesias-Hernandez, D., Tafader, M., Louis, E.D. and Cosentino, S. (2022) Motor Features Associated with Cognition in Non-Demented Individuals with Essential Tremor. Journal of the Neurological Sciences, 439, Article ID: 120323. https://doi.org/10.1016/j.jns.2022.120323 |
| [15] | Cartella, S.M., Bombaci, A., Gallo, G., Ledda, C., Pengo, M., Pignolo, A., Pozzi, F.E., Spina, E., Trinchillo, A., Palermo, G., and Terranova, C., On Behalf of EduNet SIgN (2022) Essential Tremor and Cognitive Impairment: Who, How, and Why. Neurological Sciences, 43, 4133-4143. https://doi.org/10.1007/s10072-022-06037-4 |
| [16] | Chandran, V., Pal, P.K., Reddy, J.Y., Thennarasu, K., Yadav, R. and Shivashankar, N. (2012) Non-Motor Features in Essential Tremor. Acta Neurologica Scandinavica, 125, 332-337. https://doi.org/10.1111/j.1600-0404.2011.01573.x |
| [17] | Sengul, Y., Sengul, H.S., Yucekaya, S.K., Yucel, S., Bakim, B., Pazarci, N.K. and Ozdemir, G. (2015) Cognitive Functions, Fatigue, Depression, Anxiety and Sleep Disturb-ances: Assessment of Nonmotor Features in Young Patients with Essential Tremor. Acta Neurologica Belgica, 115, 281-287. https://doi.org/10.1007/s13760-014-0396-6 |
| [18] | Li, Z.W., Xie, M.J., Tian, D.S., Li, J.J., Zhang, J.P., Jiao, L., Tang, Z.P. and Tang, R.H. (2011) Characteristics of Depressive Symptoms in Essential Tremor. Journal of Clinical Neuroscience, 18, 52-56.
https://doi.org/10.1016/j.jocn.2010.05.021 |
| [19] | Dogu, O., Louis, E.D., Sevim, S., Kaleagasi, H. and Aral, M. (2005) Clinical Characteristics of Essential Tremor in Mersin, Turkey—A Population-Based Door-to-Door Study. Jour-nal of Neurology, 252, 570-574.
https://doi.org/10.1007/s00415-005-0700-8 |
| [20] | 王淅, 陈生弟. 特发性震颤非运动症状研究进展[J]. 中国现代神经疾病杂志, 2014, 14(5): 446-449. |
| [21] | Ratajska, A.M., Scott, B.M., Lopez, F.V., Kenney, L.E., Foote, K.D., Okun, M.S., Price, C. and Bowers, D. (2022) Differential Contributions of Depression, Apathy and Anxiety to Neuro-psychological Performance in Parkinson’s Disease versus Essential Tremor. Journal of Clinical and Experimental Neu-ropsychology, 44, 651-664.
https://doi.org/10.1080/13803395.2022.2157796 |
| [22] | Chen, J., Yao, J., Chen, L., Miao, H., Mao, C. and Liu, C. (2015) [Sleep Disorders Associated with Essential Tremor and Parkinson’s Disease]. National Medical Journal of China, 95, 205-209. (In Chinese) |
| [23] | Barut, B.O., Tascilar, N. and Varo, A. (2015) Sleep Disturbances in Essential Tremor and Parkinson Disease: A Polysomnographic Study. Journal of Clinical Sleep Medicine: JCSM, 11, 655-662. https://doi.org/10.5664/jcsm.4778 |
| [24] | Rodríguez-Blázquez, C., Forjaz, M.J., Kurtis, M.M., Balestrino, R. and Martinez-Martin, P. (2018) Rating Scales for Movement Disorders with Sleep Disturbances: A Narrative Review. Fron-tiers in Neurology, 9, Article 435.
https://doi.org/10.3389/fneur.2018.00435 |
| [25] | Bugalho, P., Salavisa, M., Borbinha, C., Fernandes, M., Meira, B., Barbosa, R. and Mendonca, M. (2021) REM Sleep Behaviour Disorder in Essential Tremor: A Polysomnographic Study. Journal of Sleep Research, 30, e13050.
https://doi.org/10.1111/jsr.13050 |
| [26] | Ondo, W.G., Sutton, L., Dat Vuong, K., Lai, D. and Jankovic, J. (2003) Hearing Impairment in Essential Tremor. Neurology, 61, 1093-1097. https://doi.org/10.1212/01.WNL.0000086376.40750.AF |
| [27] | Balaban, H., Altunta？, E.E., Uysal, I.O., Sentürk, I.A. and Topakta？, S. (2012) Audio-Vestibular Evaluation in Patients with Essential Tremor. European Archives of Oto-Rhino-Laryngology, 269, 1577-1581.
https://doi.org/10.1007/s00405-011-1801-x |
| [28] | 侯立军, 马立, 耿荔蓉, 岳晓丽, 朱榆红, 李燕. 特发性震颤听力障碍特点及其本质分析[J]. 国际神经病学神经外科学杂志, 2021, 48(1): 46-49. |
| [29] | Sengul, Y. (2020) Audi-tory and Olfactory Deficits in Essential Tremor—Review of the Current Evidence. Tremor and Other Hyperkinetic Movements, 10, 3. https://doi.org/10.5334/tohm.57 |
| [30] | Louis, E.D., Bromley, S.M., Jurewicz, E.C. and Watner, D. (2002) Olfactory Dysfunction in Essential Tremor: A Deficit Unrelated to Disease Duration or Severity. Neurology, 59, 1631-1633.
https://doi.org/10.1212/01.WNL.0000033798.85208.F2 |
