Background:FoxP3 gene variants have been linked to
endometriosis, infertility, and autoimmune illnesses, according to numerous researches. Maternal sensitivity to
the PE gene and the genetic variations of FoxP3 has not been thoroughly investigated. Objective:Investigation of the immune-histochemical expression of FoxP3 in placental
tissue of PE patients. Methods: A total of 26 pre-eclamptic women as a case and 26 ethnically matched
healthy pregnant women as a control group aged between 18 and 40 years old of
different gravidity and parity referred to the labor ward for delivery either
by vaginal delivery or cesarean section was enrolled to investigate the immunohistochemical expression of FOXP3 in placental
tissue of PE patients.Results: Lower expression of FOXP3 IHC was statistically significant and noted in the group of preeclampsia
compared to the healthy control group. Lower gestational age
at delivery and a higher percentage of cesarean section were
statistically significant and noted in the group of preeclampsia compared to the
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