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肝细胞癌相关内质网应激的研究进展
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Abstract:
内质网应激在癌症中具有多种调节作用。当mRNA翻译速率与蛋白折叠效率之间平衡被破坏，错误折叠或未折叠的蛋白质在内质网腔中的积累时，引起内质网应激，并触发未折叠蛋白质反应，以恢复蛋白质合成或者诱导细胞死亡。肝细胞癌是全球最常见和最致命的癌症之一，预后极差。内质网应激为肝细胞癌的关键因素，与肝细胞癌的发生和发展、耐药性和死亡调节密切相关，靶向内质网应激已成为潜在的抗肿瘤策略。本文结合近5年的相关文献，针对内质网应激对肝癌的影响进行概述。
ER stress was confirmed to be multiple regulators of cancer. When there are imbalances between the rate of mRNA translation and the efficiency of protein folding and unfolded or incompletely folded proteins accumulating in the ER, the cell experiences ER stress. This process triggers the unfolded protein response in order to restore protein synthesis or induce cell death. Hepatocellular carcinoma is one of the most common and deadly cancers worldwide with an extremely poor prognosis. ER stress has gradually been shown to be a major mechanism of hepatocellular carcinoma and was associated with tumorigenesis, development, drug resistance and cell death, targeting ER stress has emerged as a potential anti-tumor strategy. We searched for relevant publications in the last five years and present an overview of the current knowledge that links ER stress and HCC.
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