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细菌外膜囊泡调节免疫细胞功能活动的研究进展
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Abstract:
外膜囊泡(OMV)是一种来源于革兰氏阴性菌的纳米级大小的球形蛋白脂质体。OMVS可以运输多种化学成分，包括脂类、脂多糖、膜包埋的相关蛋白和小分子、肽聚糖和核酸，特别是粘附素和毒素等毒力因子通常在OMV中富集。OMVs在细菌与宿主细胞间沟通、微生物毒力和调节细菌群落内的微生物相互作用以及调节宿主免疫反应方面发挥着不同的作用。它们在细菌培养和感染过程中无处不在地产生，现在被认为在宿主与细菌的相互作用中发挥着关键作用。在这里，我们着重讨论了OMVs对宿主免疫细胞的影响作用，重点介绍它们对各类免疫细胞所做出的免疫功能调节的研究现状。
The outer membrane vesicles (OMV) is a nanoscale-sized spherical protein liposome derived from gram-negative bacteria. OMVS can transport a variety of chemical components, including lipids, lipopolysaccharides, membrane embedded related proteins and small molecules, peptidmosaccharides, and nucleic acids, particularly adhesives and toxins, which are usually rich in OMV. OMVs play different roles in bacteria and host cell intervals, microbial toxicity and microbial interactions in the formation of bacterial communities and regulating the host immune response. They are everywhere in bacterial culture and infection, and they are now considered to play a key role in the interaction of the host and bacteria. Here, we focused on the effects of OMVs on host immune cells, focusing on the research status of immune function adjustment made by various types of immune cells.
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