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原发性气管腺泡细胞癌1例报告及文献复习
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Abstract:
背景:腺泡细胞癌(acinic cell carcinoma, ACC)是一种罕见的唾液腺恶性肿瘤,原发性肺内ACC更为罕见,主要通过手术切除肿瘤来治疗。总结:在本报告中,患者为一名8岁男孩,因原发性气管ACC伴间歇性呼吸困难入院。影像学检查和电子纤维喉镜检查显示,在主气管右侧壁(约在T1椎体水平)有一个不规则组织肿块,阻塞了约90%的气管。我们的医疗团队灵活采用低温等离子刀和内镜联合的方法,一次性完全切除肿瘤,避免了对患者造成严重创伤,病理结果证实为腺泡细胞癌。现该男孩已随访2年余,一直保持健康。结论:本病例报告提示低温等离子刀和内镜的联合应用技术在气管肿瘤治疗中的作用。
Background: Acinar cell carcinoma is a rare malignant tumor of the salivary gland and Primary ac-inar cell carcinoma of the lung is even rarer. Surgical excision is its treatment mainly. Case Presen-tation/Summary: In the current report, a 8-year-old boy was admitted in our hospital for primary bronchial acinar cell carcinoma with intermittent dyspnea. Imaging examination and Electronic fi-ber laryngoscope revealed a large irregular tissue mass in the right side of the trachea (about the level of T1 vertebral body) blocking about 90% of the trachea. Our medical team flexibly adopted the combined application of low-temperature plasma knife and endoscopy to completely remove the tumor at one time, avoiding great trauma to the patient and the pathological findings confirmed the presentation of acinar cell carcinoma. The boy survived healthily until now (after operation 2 years). Conclusion: This case report draws attention to the importance of novel surgical resection with low-temperature plasma knife and endoscopy in trachea tumor.
[1] | Zhang, L.H., et al. (2014) Clinicopathological Analysis of Salivary Gland Acinic Cell Carcinoma. Journal of Oral and Maxillofacial Surgery, 24, 360-363. |
[2] | Papla, B., Czajkowski, W., Kocoń, P. and Rys, J. (2011) Pulmonary Acinic Cell Carcinoma (Fechner Tumour) with Carcinoid Component. A Case Report. Polish Journal of Pathology, 62, 105-107. |
[3] | Ide, S., Sawai, T. and Kaku, N. (2009) Case of Pulmonary Adenocarcinoma with Co-Existing Pulmonary Actinomycosis in One Region of the Lung. Nihon Kokyuki Gakkai Zasshi, 47, 823-827. |
[4] | Sabaratnam, R.M., Anun-athan, R. and Govender, D. (2004) Acinic Cell Carcinoma: An Unusual Cause of Bronchial Obstruction in a Child. Pedi-atric and Developmental Pathology, 7, 521-526.
https://doi.org/10.1007/s10024-004-1014-z |
[5] | Florian, H., Matthias, B., Rainer, W., et al. (2019) Enhancer Hi-jacking Activates Oncogenic Transcription Factor NR4A3 in Acinic Cell Carcinomas of the Salivary Glands. Nature Communications, 10, 368-374.
https://doi.org/10.1038/s41467-018-08069-x |
[6] | Yang, S.D., Li, L., Zeng, M. and Zhu, X.J. (2010) Myoepithelial Carcinoma of Intraoral Minor Salivary Glands: A Clinicopathological Study of 7 Cases and Review of the Literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 110, 85-93. https://doi.org/10.1016/j.tripleo.2010.02.023 |
[7] | Segletes, L.A., Steffee, C.H., et al. (1999) Cytology of Primary Pulmonary Mucoepidermoid and Adenoid Cystic Carcinoma—A Report of Four Cases. Acta Cytologica, 43, 1091-1097. https://doi.org/10.1159/000331358 |
[8] | Nie, L., Zhou, C., et al. (2019) Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review. International Journal of Surgical Pathology, 27, 584-592.
https://doi.org/10.1177/1066896919836499 |
[9] | Foote, F.W. and Frazell, E.L. (1953) Tumor of Major Salivary Glands. Cancer, 6, 1065-1133.
https://doi.org/10.1002/1097-0142(195311)6:6<1065::AID-CNCR2820060602>3.0.CO;2-0 |
[10] | Sen, R., Bhutani, N. Kamboj, J., et al. (2018) Primary Acinic Cell Carcinoma of the Breast: A Case Report with a Clinicopathological and Immunohistochemical Study of a Rare Breast Cancer Subtype. Annals of Medicine and Surgery, 35, 137-140. https://doi.org/10.1016/j.amsu.2018.09.030 |
[11] | Babu, S.S., Sunil, S., Prathap, A., et al. (2020) Acinic Cell Carci-noma of the Posteriorbuccal Mucosa: A Rare Case Report. Journal of Cancer Research and Therapeutics, 16, 675-679. https://doi.org/10.4103/jcrt.JCRT_399_18 |
[12] | Travis, W.D., Burke, A.P., et al. (2015) WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. Fourth Edition, The International Agency for Research on Cancer, Lyon, 99-105. |
[13] | Fechner, R.E., Bentinck, B.R. and Askew, J.B. (1972) Acinic Cell Tumor of the Lung. A Histologic and Ultrastructural Study. Cancer, 29, 501-508.
https://doi.org/10.1002/1097-0142(197202)29:2<501::AID-CNCR2820290241>3.0.CO;2-B |
[14] | Ukoha, O.O., Quartararo, P., Carter, D., Kashgarian, M. and Ponn, R.B. (1999) Acinic Cell Carcinoma of the Lung with Etastasis to Lymph Nodes. Chest, 115, 591-595. https://doi.org/10.1378/chest.115.2.591 |
[15] | Lee, H.Y., Mancer, K. and Koong, H.N. (2003) Primary Acinic Cell Carcinoma of the Lung with Lymph Node Metastasis. Archives of Pathology & Laboratory Medicine, 127, e216-e219.
https://doi.org/10.5858/2003-127-e216-PACCOT |
[16] | Amit, C. (2013) Primary Salivary Type Lung Tumor: Mu-coepidermoid Carcinoma. Respiratory Medicine Case Reports, 9, 18-20. https://doi.org/10.1016/j.rmcr.2013.03.005 |
[17] | Chen, X.Y., Zhang, Y.J., Luo, F.X., et al. (2021) Right Pneumo-nectomy for Primary Large Acinic Cell Carcinoma (AciCC) with Severe Mediastinal Deviation: A Case Report and Liter-ature Review. BMC Surgery, 21, 368.
https://doi.org/10.1186/s12893-021-01351-8 |
[18] | Omlie, J.E. and Koutlas, I.G. (2010) Acinic Cell Carcinoma of Minor Salivary Glands: A Clinicopathologic Study of 21 Cases. Journal of Oral and Maxillofacial Surgery, 68, 2053-2057. https://doi.org/10.1016/j.joms.2010.04.003 |
[19] | Triantafillidou, K., Iordanidis, F. and Psomaderis, K. (2010) Acinic Cell Carcinoma of Minor Salivary Glands: A Clinical and Immunohistochemical Study. Journal of Oral and Maxillofacial Surgery, 68, 2489-2496.
https://doi.org/10.1016/j.joms.2009.09.065 |
[20] | Katz, D.R. and Bubis, J.J. (1976) Acinic Cell Tumor of the Bron-chus. Cancer, 38, 830-832.
https://doi.org/10.1002/1097-0142(197608)38:2<830::AID-CNCR2820380228>3.0.CO;2-E |