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卵泡刺激素对绝经后2型糖尿病脂代谢影响的潜在机制研究进展
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Abstract:
2型糖尿病(Type 2 diabetes, T2DM)合并脂代谢紊乱是导致动脉粥样硬化性大血管病变的重要危险因素，心、脑血管动脉粥样硬化已成为其主要死亡原因。以往综述主要集中在雌激素对女性心血管疾病、动脉粥样硬化、脂代谢等的影响，少有总结卵泡刺激素(Follicle stimulating hormones, FSH)与绝经后血脂异常、心血管疾病风险的相关性。本篇综述结合国内外相关文献，主要目的是强调FSH对绝经后T2DM脂代谢的影响及潜在分子机制，为糖尿病降脂治疗提供新思路。
Type 2 diabetes mellitus (T2DM) combined with disorders of lipid metabolism is an important risk factor for atherosclerotic macroangiopathy, and cardiovascular and cerebrovascular atherosclerosis has become its main cause of death. Previous reviews have focused on the effects of estrogen on car-diovascular disease, atherosclerosis, and lipid metabolism in women, and few have summarized the correlation between follicle-stimulating hormones (FSH) and postmenopausal dyslipidemia and cardiovascular disease risk. The main purpose of this review, combined with related domestic and international literature, is to highlight the effects and potential molecular mechanisms of FSH on li-pid metabolism in postmenopausal T2DM, and to provide new ideas for lipid-lowering therapy in diabetes.
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