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OCT生物标志物与DME患者抗VEGF治疗预后的相关性
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Abstract:
糖尿病黄斑水肿(DME)在全球范围内严重威胁患者视力。抗VEGF治疗是目前DME的一线治疗方式，部分患者对这一治疗方式反应较差，有研究发现，某些OCT生物标志物与抗VEGF治疗不应答有一定的相关性。本文从DME的发病机制，抗VEGF治疗原理及OCT生物标志物与抗VEGF治疗的相关性展开描述，分析DME患者的OCT特征，指导诊断及治疗。
Diabetic macular edema (DME) is a serious threat to visual acuity worldwide. Anti-VEGF therapy is the current first-line treatment for DME, and some patients have poor response to this treatment. Some studies have found that some OCT biomarkers are associated with non-response to anti-VEGF therapy. In this paper, the pathogenesis of DME, the principle of anti-VEGF therapy and the correla-tion between OCT biomarkers and anti-VEGF therapy were described, and the OCT features of DME patients were analyzed to guide diagnosis and treatment.
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