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脓毒症合并肝功能损害研究现状
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Abstract:
脓毒症是因感染所导致的一种全身性炎症反应综合征，具有发病率高、发病机制复杂、病死率高等特点，是急危重症医学面临的重要临床问题。肝脏是人体免疫、代谢和解毒的重要器官，也是脓毒症早期易侵入和损伤的器官之一。急性肝损伤可发生在脓毒症的任何阶段，这也是病情进入多器官功能障碍综合征的重要标志。研究表明，早期肝功能损害是脓毒症患者预后的重要预警指标，早期诊断、干预和治疗，对于改善脓毒症患者预后具有重要意义。
Sepsis is a systemic inflammatory syndrome caused by infection. It is characterized by high mor-bidity, complex pathogenesis and high mortality, and is an important clinical problem faced by acute and critical medicine. Liver is an important organ for human immunity, metabolism and de-toxification, and it is also one of the organs easily invaded and damaged in the early stage of sepsis. Acute liver injury can occur at any stage of sepsis and is an important marker for the progression of multiple organ dysfunction syndrome. Studies have shown that early liver function damage is an important predictor of the prognosis of patients with sepsis, and early diagnosis, intervention and treatment of liver function damage are of great significance for improving the prognosis of patients with sepsis.
| [1] | 赵国桢, 郭玉红, 李博, 等. 中医药防治脓毒症的研究进展[J]. 中国中药杂志, 2017, 42(8): 1423-1429. |
| [2] | Fleis, C.C., Scherag, A., Adhikari, N.K., et al. (2016) Assessment of Global Incidence and Mortality of Hospital-Treated Sep-sis. American Journal of Respiratory and Critical Care Medicine, 193, 259-272.
https://doi.org/10.1164/rccm.201504-0781OC |
| [3] | Mouncey, P.R., Osborn, T.M., Power, G.S., et al. (2015) Trial of Early, Goal-Directed Resuscitation for Septic Shock. The New England Journal of Medicine, 372, 1301-1311. https://doi.org/10.1056/NEJMoa1500896 |
| [4] | Ama, A., Mkm, B., Asb, C., et al. (2021) Granisetron Attenuates Liver Injury and Inflammation in a Rat Model of Cecal Ligation and Puncture-Induced Sepsis. Journal of Pharmacolog-ical Sciences, 147, 358-366.
https://doi.org/10.1016/j.jphs.2021.08.005 |
| [5] | 易钊泉, 范春. 脓毒症肝损伤的临床研究[J]. 胃肠病学和肝病学杂志, 2017, 26(2): 199-202. |
| [6] | Feng, H., Chen, J., Wang, H., et a1. (2017) Roflumilast Reverses Polymicrobial Sepsis—Induced Liver Damage by Inhibiting Inflammation in Mice. Laboratory Investigation, 97, 1008-1009. https://doi.org/10.1038/labinvest.2017.59 |
| [7] | Kortgen, A., Paxian, M., Werth, M., et al. (2009) Prospective As-sessment of Hepatic Function and Mechanisms of Dysfunction in the Critically Ill. Shock, 32, 358-365. https://doi.org/10.1097/SHK.0b013e31819d8204 |
| [8] | Koskinas, J. and Archimandritis, A. (2008) Liver Histology in ICU Patients Dying from Sepsis: A Clinico-Pathological Study. World Journal of Gastroenterology, 14, 1389-1393. https://doi.org/10.3748/wjg.14.1389 |
| [9] | Bellido-Caparó, A., Maria, T.G. et al. (2019) Hypoxic Hepatitis in an Extensive Aortic Disecction: Case Report. Revista de Gastroenterología del Perú, 39, 88-90. |
| [10] | Strnad, P., Tacke, F., Koch, A., et al. (2017) Liver-Guardian, Modifier and Target of Sepsis. Nature Reviews Gastroenterology & Hepatology, 14, 55-66. https://doi.org/10.1038/nrgastro.2016.168 |
| [11] | Fuhrmann, V., J？ger, B., Zubkova, A., et al. (2010) Hypoxic Hepatitis—Epidemiology, Pathophysiology and Clinical Management. Wiener klinische Wochenschrift, 122, 129-139. https://doi.org/10.1007/s00508-010-1357-6 |
| [12] | 邱梅红, 袁捷. 缺氧性肝炎的研究进展[J]. 胃肠病学和肝病学杂志, 2016, 25(3): 337-339. |
| [13] | Charlton, M., Sims, M., Coats, T., et al. (2017) The Microcirculation and Its Measurement in Sepsis. Journal of the Intensive Care Society, 18, 221-227. https://doi.org/10.1177/1751143716678638 |
| [14] | 孙宁, 栾正刚. 脓毒症合并肝损伤的诊断与治疗研究进展[J]. 中国临床新医学, 2018, 11(3): 294-298. |
| [15] | 郭海雷, 卢才教, 刘政军, 等. 脓毒症大鼠早期血管内皮和心肌损害及其相关性研究[J]. 中国现代医生, 2018, 56(10): 37-41. |
| [16] | 瞿泽祥, 李刚, 等. APN、hs-CRP、ET-1及NO在原发性高血压患者中的检测价值[J]. 湖南师范大学学报: 医学版, 2017(14): 68-71. |
| [17] | Je, J., Kim, H., Park, E.J., et al. (2020) Fermentation of Sprouted Ginseng (Panax ginseng) Increases Flavonoid and Phenolic Contents to Attenuate Alcoholic Hangover and Acute Liver Injury in Mice. The American Journal of Chinese Medicine, 49, 1-16. https://doi.org/10.1142/S0192415X21500075 |
| [18] | 赵利利, 袁东亚, 孙芳云. 肝血窦在内毒素致肝损伤中的作用[J]. 临床肝胆病杂志, 2016, 32(1): 182-184. |
| [19] | 孙雪东, 严一核, 张亦婷, 等. 血必净对脓毒症肝损伤大鼠氧化应激及炎症状态的影响[J]. 中国现代应用药学, 2016, 33(10): 1255-1259. |
| [20] | Liu, X., Yang, X., Han, L., et al. (2017) Pterostilbene Alleviates Polymicrobial Sepsis-Induced Liver Injury: Possible Role of SIRT1 Signaling. Interna-tional Immunopharmacology, 49, 50-59. https://doi.org/10.1016/j.intimp.2017.05.022 |
| [21] | Wu, T., Wang, L., An, J., et al. (2017) Noninvasive Imaging of Stored Red Blood Cell-Transfusion Aggravating Sepsis-Induced Liver Injury Associated with Increased Activation of M1-Polarized Kupffer Cells. Shock, 48, 459-466.
https://doi.org/10.1097/SHK.0000000000000867 |
| [22] | Sarto, M., Tamura, A.S., Alves, V.S., et al. (2020) P2X7 Receptor Deletion Attenuates Oxidative Stress and Liver Damage in Sepsis. Purinergic Signalling, 16, 561-572. https://doi.org/10.1007/s11302-020-09746-7 |
| [23] | 王湘江, 郑春和, 吕强. 前列地尔对脓毒症急性肝损伤患者炎症反应及肝功能的影响[J]. 中国现代医药杂志, 2018, 20(3): 71-73. |
| [24] | 管建慧, 易钊泉. 脓毒症肝损伤的致病机制及治疗新进展[J]. 中国急救医学, 2019, 39(6): 601-604. |
| [25] | Brenner, C., Galluzzi, L., Kepp, O., et al. (2013) Decoding Cell Death Signals in Liver Inflammation. Journal of Hepatology, 59, 583-594. https://doi.org/10.1016/j.jhep.2013.03.033 |
| [26] | Gavin, N.C., Button, E., Castillo, M.I., et al. (2018) Does a Dedi-cated Lumen for Parenteral Nutrition Administration Reduce the Risk of Catheter-Related Bloodstream Infections? A Systematic Literature Review. Journal of Infusion Nursing, 41, 122-130. https://doi.org/10.1097/NAN.0000000000000270 |
| [27] | 李杨宇婧, 柏海涛. 肠内和肠外营养对脓毒症患者肝损伤的保护作用[J]. 中国现代普通外科进展, 2019, 22(9): 717-719. |
| [28] | 刘科, 田伏洲, 李可洲, 等. 高压氧对模拟高原急性缺氧条件下脓毒症大鼠肝损伤的保护作用[J]. 解放军医学杂志, 2011, 36(2): 64-68. |
| [29] | 张萍, 张良祥. 高压氧对运动疲劳小鼠肝脏组织抗氧化能力和ATP酶代谢的影响[J]. 吉林大学学报(医学版), 2018, 44(6): 92-96. |
| [30] | 刘培, 周青山, 李彬彬, 等. 高压氧对脓毒症大鼠膈肌损伤的保护作用[J]. 中华航海医学与高气压医学杂志, 2010, 17(2): 107-109. |
| [31] | 刘肖君, 曾敏, 符秀虹, 等. 乌司他丁抑制NF-κB通路对脓毒症急性肝损伤的保护作用[J]. 肝脏, 2019, 24(8): 918-920. |
| [32] | 寇夕, 刘虹. 乌司他丁通过p38丝裂原活化蛋白激酶通路治疗大鼠脓毒症急性肝损伤的相关性研究[J]. 中华危重症医学杂志, 2017, 10(5): 309-315. |
