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高尿酸血症与冠心病关系研究进展
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Abstract:
血清尿酸(serum uric acid, SUA)是人类或类人猿嘌呤代谢的最终代谢产物，随着生活水平的提高，饮食水平逐渐改善，血清尿酸也逐渐升高。心血管疾病，尤其是冠心病是当今世界上最普遍、最严重的心脏病之一，它的发病率高、死亡率高，是目前危害全球人类健康的世界卫生难题。近年来多项研究表明，血清尿酸与冠心病有关，且还没能彻底揭示其关系。本文旨在探讨高尿酸血症、内皮功能紊乱、氧化应激、炎症等因素，并探讨降尿酸盐治疗对心血管疾病的作用，以期减少冠心病的患病率。
Serum uric acid is the final metabolite of human or anthropoid purine metabolism. With the im-provement of living standards and diet level, serum uric acid also increases gradually. Cardiovascu-lar disease, especially coronary heart disease, is one of the most common and serious heart diseases in the world today, with high morbidity and mortality. It is a global health problem that endangers human health all over the world. In recent years, many studies have shown that serum uric acid is related to coronary heart disease, but the relationship has not been fully revealed. The objective of this study was to investigate the factors such as hyperuricemia, inflammation, endothelial dysfunc-tion, and oxidative stress, and to explore the effect of uricite-lowering therapy on cardiovascular diseases in order to reduce the prevalence of coronary heart disease.
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