补中益气汤治疗肾性蛋白尿的Meta分析
Meta Analysis of Buzhong Yiqi Decoction on Renal Proteinuria

目的：系统评价补中益气汤及其加减方干预肾性蛋白尿的临床疗效。方法：计算机检索中国知网(CNKI)、万方数据库(Wanfang Data)、中国生物医学文献数据库(CBM)、重庆维普数据库(VIP)、PubMed、Embase、The Cochrane Library，收集补中益气汤及其加减方干预肾性蛋白尿的文献，检索时间为自建库起至2022年04月10日。对纳入文献使用NoteExpress进行人工筛查和整理，用Cochrane系统评价手册评估，提取有效数据，采用RevMan5.4.1软件进行Meta分析。结果：纳入26篇文献，共1708例患者。Meta分析结果显示：与对照组相比，补中益气汤治疗肾性蛋白尿，能提升临床总有效率，减轻24 h尿蛋白定量、血清肌酐、尿素氮。结论：证据表明，补中益气汤干预降低肾性蛋白尿有确切疗效，现阶段纳入研究文献可能欠严谨，上述观点仍需要更多高质量的证据予以验证。
Objective: To overall evaluate the clinical efficacy of Buzhong Yiqi Decoction in reducing renal proteinuria. Methods: By searching and gathering literatures of Buzhong Yiqi Decoction in reducing renal proteinuria published before April 10, 2022 from CNKI, Wanfang Data, CBM, PubMed, Embase, and the Cochrane Library. After screening and collating all involved trials with the help of NoteExpress, the author extracts valid data under the guidance of Cochrane Handbook, and adopts RevMan5.4.1 to conduct Meta-analysis. Results: A total of 26 trials and 1708 patients were included. The Meta-analysis results displayed that compared with the control group, used Buzhong Yiqi Decoction in the experimental group increased the total clinical efficacy rate ,and reduced the 24-hour urine protein quantitation, reduced the serum creatinine and the urea nitrogen. Conclusion: As indicated above, Buzhong Yiqi Decoction has curative effect in reducing renal proteinuria, however, due to the inclusion of research literature at this stage may be less rigorous, the conclusion requires more authoritative supporting information to verify.