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肥胖对膝关节骨性关节炎的影响研究进展
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Abstract:
膝关节骨关节炎是一种进展性的慢性退行病变，其以关节软骨变性、破坏及骨赘的形成为特征。关节进行性疼痛、活动度降低，且晚期伴有关节畸形，是膝关节骨关节炎的主要临床表现。原发性膝关节骨关节炎的病因尚未完全清楚，临床提示，其与肥胖、性别、年龄、职业以及膝关节长期慢性损伤密切相关。其中，肥胖在膝关节骨性关节炎中起着很重要的作用，本文将从病因、发病机制、手术治疗三方面探讨肥胖对膝关节骨性关节炎影响的研究进展，为膝关节骨性关节炎的诊治提供思路与参考。
Osteoarthritis of the knee is a progressive chronic degenerative lesion characterized by the de-generation and destruction of the articular cartilage and the formation of osteophytes. Progressive joint pain, reduced range of motion, and late stage with joint deformity are the main clinical manifestations of KOA. The etiology of primary knee osteoarthritis is not fully clear, and it clinically suggests that it is closely related to obesity, gender, age, occupation, and long-term chronic injury of the knee. Among them, obesity plays a very important role in knee osteoarthritis. This paper will discuss the research progress of the influence of obesity on knee osteoarthritis from three aspects of etiology, pathogenesis and surgical treatment, in order to provide evidence as well as new way of thinking for clinical application of knee osteoarthritis.
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