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类风湿关节炎合并冠心病的相关探讨
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Abstract:
类风湿关节炎是一种常见的慢性自身免疫性疾病，其合并发生心血管疾病的概率较普通人群显著增高，其中冠心病占比较大，导致类风湿关节炎合并冠心病发作的传统危险因素多种多样，许多新型危险因素如炎症反应、内皮损伤等也在发病机制中起到重要作用，早期发现危险因素和了解相应治疗措施对降低疾病风险有着积极作用，现对其研究进展进行系统综述。
Rheumatoid arthritis is a common chronic autoimmune disease, compared with the general pop-ulation, the probability of cardiovascular disease is significantly increased, and coronary heart disease accounts for a large proportion, traditional risk factors leading to the onset of rheumatoid arthritis with coronary heart disease are diverse, many new risk factors such as inflammation, endothelial injury and so on also play an important role in the pathogenesis, early detection of risk factors and understanding of corresponding treatment measures play a positive role in reducing the risk of disease. This paper systematically reviews the research progress of it.
| [1] | Ikonomidis, I., Tzortzis, S. andreadou, I., et al. (2014) In-creased Benefit of Interleukin-1 Inhibition on Vascular Function, Myocardial Deformation, and Twisting in Patients with Coronary Artery Disease and Coexisting Rheumatoid Arthritis. Circulation: Cardiovascular Imaging, 7, 619-628. https://doi.org/10.1161/CIRCIMAGING.113.001193 |
| [2] | Ljung, L., Askling, J., Rantap？？-Dahlqvist, S., et al. (2014) The Risk of Acute Coronary Syndrome in Rheumatoid Arthritis in Relation to Tumour Necrosis Factor Inhibitors and the Risk in the General Population: A National Cohort Study. Arthritis Research & Therapy, 16, R127. https://doi.org/10.1186/ar4584 |
| [3] | Toussirot, é. (2015) Effects of TNFα Inhibitors on Adiposity and Other Car-diovascular Risk Factors: Implications for the Cardiovascular Prognosis in Patients with Rheumatoid Arthritis. Expert Opinion on Drug Safety, 14, 525-532.
https://doi.org/10.1517/14740338.2015.1007041 |
| [4] | Kaur, K., Kalra, S. and Kaushal, S. (2014) Systematic Re-view of Tofacitinib: A New Drug for the Management of Rheumatoid Arthritis. Clinical Therapeutics, 36, 1074-1086. https://doi.org/10.1016/j.clinthera.2014.06.018 |
| [5] | Kremer, J.M. (2021) Methotrexate and Cardiovascular Disease in Patients with Rheumatoid Arthritis: Insights and Novel Speculations. The Journal of Rheumatology, 48, 793-795. https://doi.org/10.3899/jrheum.201415 |
| [6] | Bullock, J., Rizvi, S., Saleh, A.M., et al. (2018) Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical Principles and Practice, 27, 501-507. https://doi.org/10.1159/000493390 |
| [7] | Littlejohn, E.A. and Monrad, S.U. (2018) Early Diagnosis and Treatment of Rheumatoid Arthritis. Primary Care, 45, 237-255. https://doi.org/10.1016/j.pop.2018.02.010 |
| [8] | Lin, Y.J., Anzaghe, M. and Schülke, S. (2020) Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis. Cells, 9, 880. https://doi.org/10.3390/cells9040880 |
| [9] | Blum, A. and Adawi, M. (2019) Rheumatoid Arthritis (RA) and Car-diovascular Disease. Autoimmunity Reviews, 18, 679-690. https://doi.org/10.1016/j.autrev.2019.05.005 |
| [10] | Semb, A.G., Ikdahl, E., Wibetoe, G., et al. (2020) Atherosclerotic Cardiovascular Disease Prevention in Rheumatoid Arthritis. Nature Reviews Rheumatology, 16, 361-379. https://doi.org/10.1038/s41584-020-0428-y |
| [11] | Li, H., Sun, K., Zhao, R., et al. (2018) Inflammatory Biomarkers of Coronary Heart Disease. Frontiers in Bioscience (Schol Ed), 10, 185-196. https://doi.org/10.2741/s508 |
| [12] | L？gstrup, B.B., Olesen, K., Masic, D., et al. (2020) Impact of Rheumatoid Ar-thritis on Major Cardiovascular Events in Patients with and without Coronary Artery Disease. Annals of Rheumatic Diseases, 79, 1182-1188.
https://doi.org/10.1136/annrheumdis-2020-217154 |
| [13] | Avi？a-Zubieta, J.A., Choi, H.K., Sadatsafavi, M., et al. (2008) Risk of Cardiovascular Mortality in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies. Arthritis & Rheumatology, 59, 1690-1697.
https://doi.org/10.1002/art.24092 |
| [14] | Humphreys, J.H., Warner, A., Chipping, J., et al. (2014) Mortality Trends in Patients with Early Rheumatoid Arthritis over 20 Years: Results from the Norfolk Arthritis Register. Arthritis Care & Research (Hoboken), 66, 1296-1301.
https://doi.org/10.1002/acr.22296 |
| [15] | Aubry, M.C., Maradit-Kremers, H., Reinalda, M.S., et al. (2007) Differ-ences in Atherosclerotic Coronary Heart Disease between Subjects with and without Rheumatoid Arthritis. The Journal of Rheumatology, 34, 937-942. |
| [16] | Dalbeni, A., Giollo, A., Bevilacqua, M., et al. (2020) Traditional Cardiovascular Risk Factors and Residual Disease Activity Are Associated with Atherosclerosis Progression in Rheumatoid Arthritis Patients. Hypertension Research, 43, 922-928. https://doi.org/10.1038/s41440-020-0441-1 |
| [17] | Chung, C.P., Oeser, A., Raggi, P., et al. (2005) Increased Coronary-Artery Atherosclerosis in Rheumatoid Arthritis: Relationship to Disease Duration and Cardiovascular Risk Factors. Arthritis & Rheumatology, 52, 3045-3053.
https://doi.org/10.1002/art.21288 |
| [18] | Quevedo-Abeledo, J.C., Rúa-Figueroa, í., Sánchez-Pérez, H., et al. (2020) Comparable Effects of Traditional Cardiovascular Risk Factors on Subclinical Atherosclerosis in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Clinical and Experimental Rheumatology, 38, 917-924. |
| [19] | Tektonidou, M.G., Kravvariti, E., Konstantonis, G., et al. (2017) Subclinical Atherosclerosis in Systemic Lupus Erythematosus: Comparable Risk with Diabetes Mellitus and Rheumatoid Arthritis. Autoimmunity Reviews, 16, 308-312.
https://doi.org/10.1016/j.autrev.2017.01.009 |
| [20] | Crowson, C.S., Gabriel, S.E., Semb, A.G., et al. (2017) Rheu-matoid Arthritis-Specific Cardiovascular Risk Scores Are Not Superior to General Risk Scores: A Validation Analysis of Patients from Seven Countries. Rheumatology (Oxford), 56, 1102-1110. https://doi.org/10.1093/rheumatology/kex038 |
| [21] | Kumar, N. and Armstrong, D.J. (2008) Cardiovascular Dis-ease—The Silent Killer in Rheumatoid Arthritis. Clinical Medicine (London), 8, 384-387. https://doi.org/10.7861/clinmedicine.8-4-384 |
| [22] | Wang, H., Li, X. and Gong, G. (2020) Cardiovascular Outcomes in Patients with Co-Existing Coronary Artery Disease and Rheumatoid Arthritis: A Systematic Review and Me-ta-Analysis. Medicine (Baltimore), 99, e19658.
https://doi.org/10.1097/MD.0000000000019658 |
| [23] | Ridker, P.M., Rifai, N., Stampfer, M.J., et al. (2000) Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction among Apparently Healthy Men. Circulation, 101, 1767-1772.
https://doi.org/10.1161/01.CIR.101.15.1767 |
| [24] | Guerra, J.D., De Santiago, A.B., Reed, S., et al. (2022) Cardi-ology Co-Management of Rheumatoid Arthritis Patients with Coronary Artery Disease as an Intervention Reduces Hospitalization Rates and Adverse Event Occurrence. Clinical Rheumatology, 41, 3715-3724. https://doi.org/10.1007/s10067-022-06335-4 |
| [25] | Jagpal, A. and Navarro-Millán, I. (2018) Cardiovascular Co-Morbidity in Patients with Rheumatoid Arthritis: A Narrative Review of Risk Factors, Cardiovascular Risk As-sessment and Treatment. BMC Rheumatology, 2, 10.
https://doi.org/10.1186/s41927-018-0014-y |
| [26] | Hannawi, S., Hannawi, H. and Al, S.I. (2020) Cardiovascular Disease and Subclinical Atherosclerosis in Rheumatoid Arthritis. Hypertension Research, 43, 982-984. https://doi.org/10.1038/s41440-020-0483-4 |
| [27] | Liao, K.P. (2017) Cardiovascular Disease in Patients with Rheumatoid Arthritis. Trends in Cardiovascular Medicine, 27, 136-140. https://doi.org/10.1016/j.tcm.2016.07.006 |
| [28] | Reiss, A.B., Silverman, A., Khalfan, M., et al. (2019) Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment. Current Pharmaceutical Design, 25, 969-986.
https://doi.org/10.2174/1381612825666190430113212 |
| [29] | Adawi, M., Firas, S. and Blum, A. (2019) Rheumatoid Arthritis and Atherosclerosis. The Israel Medical Association Journal, 21, 460-463. |
| [30] | Halacoglu, J. and Shea, L.A. (2020) Cardiovascular Risk Assessment and Therapeutic Implications in Rheumatoid Arthritis. Journal of Cardi-ovascular Translational Research, 13, 878-890.
https://doi.org/10.1007/s12265-020-09964-9 |
| [31] | England, B.R., Thiele, G.M. anderson, D.R., et al. (2018) In-creased Cardiovascular Risk in Rheumatoid Arthritis: Mechanisms and Implications. BMJ, 361, k1036. https://doi.org/10.1136/bmj.k1036 |
| [32] | Tanr？kulu, O., Sar？y？ld？z, M.A., Batmaz, O., et al. (2017) Serum GDF-15 Level in Rheumatoid Arthritis: Relationship with Disease Activity and Subclinical Atherosclerosis. Acta Reumatologica Portuguesa, 42, 66-72. |
| [33] | Jones, S.A. (2005) Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6. The Journal of Immunology, 175, 3463-3468. https://doi.org/10.4049/jimmunol.175.6.3463 |
| [34] | Kahlenberg, J.M. and Kaplan, M.J. (2013) Mechanisms of Premature Atherosclerosis in Rheumatoid Arthritis and Lupus. Annual Review of Medicine, 64, 249-263. https://doi.org/10.1146/annurev-med-060911-090007 |
| [35] | Striz, I. (2017) Cytokines of the IL-1 Family: Recog-nized Targets in Chronic Inflammation Underrated in Organ Transplantations. Clinical Science (London), 131, 2241-2256. https://doi.org/10.1042/CS20170098 |
| [36] | Robertson, A.K. and Hansson, G.K. (2006) T Cells in Atherogenesis: For Better or for Worse? Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 2421-2432. https://doi.org/10.1161/01.ATV.0000245830.29764.84 |
| [37] | Buono, C., Pang, H., Uchida, Y., et al. (2004) B7-1/B7-2 Costimulation Regulates Plaque Antigen-Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice. Circulation, 109, 2009-2015.
https://doi.org/10.1161/01.CIR.0000127121.16815.F1 |
| [38] | Zeisbrich, M., Yanes, R.E., Zhang, H., et al. (2018) Hypermetabolic Macrophages in Rheumatoid Arthritis and Coronary Artery Disease Due to Glycogen Synthase Kinase 3b Inactivation. Annals of Rheumatic Diseases, 77, 1053-1062.
https://doi.org/10.1136/annrheumdis-2017-212647 |
| [39] | 杨金娜, 刘晓光, 李覃, 等. Th17/Treg平衡在类风湿关节炎中作用的研究进展[J]. 中国药理学通报, 2013, 29(8): 1045-1048. |
| [40] | Wahlin, B., Fasth, A., Karp, K., et al. (2021) Atherosclerosis in Rheumatoid Arthritis: Associations between Anti-Cytomegalovirus IgG Antibodies, CD4+CD28null T-Cells, CD8+CD28null T-Cells and Intima-Media Thickness. Clinical and Experimental Rheumatology, 39, 578-586. https://doi.org/10.55563/clinexprheumatol/gs3o43 |
| [41] | Kisiel, B., Kruszewski, R., Juszkiewicz, A., et al. (2019) Common Atherosclerosis Genetic Risk Factors and Subclinical Atherosclerosis in Rheumatoid Arthritis: The Relevance of Disease Duration. Rheumatology International, 39, 327-336. https://doi.org/10.1007/s00296-018-4186-y |
| [42] | Sokolove, J., Brennan, M.J., Sharpe, O., et al. (2013) Brief Re-port: Citrullination within the Atherosclerotic Plaque: A Potential Target for the Anti-Citrullinated Protein Antibody Response in Rheumatoid Arthritis. Arthritis & Rheumatology, 65, 1719-1724. https://doi.org/10.1002/art.37961 |
| [43] | Brink, M., Hansson, M., Mathsson-Alm, L., et al. (2016) Rheumatoid Factor Isotypes in Relation to Antibodies against Citrullinated Peptides and Carbamylated Proteins before the Onset of Rheumatoid Arthritis. Arthritis Research & Therapy, 18, 43. https://doi.org/10.1186/s13075-016-0940-2 |
| [44] | Hejblum, B.P., Cui, J., Lahey, L.J., et al. (2018) Association between Anti-Citrullinated Fibrinogen Antibodies and Coronary Artery Disease in Rheumatoid Arthritis. Arthritis Care & Research (Hoboken), 70, 1113-1117.
https://doi.org/10.1002/acr.23444 |
| [45] | 史俊, 季晨, 雷鑫, 等. 类风湿关节炎合并冠状动脉粥样硬化性心脏病的研究进展[J]. 新医学, 2020, 51(7): 506-511. |
| [46] | Braz, N., Pinto, M., Vieira, é., et al. (2021) Renin-Angiotensin System Molecules Are Associated with Subclinical Atherosclerosis and Disease Activity in Rheumatoid Arthritis. Modern Rheumatology, 31, 119-126.
https://doi.org/10.1080/14397595.2020.1740418 |
| [47] | Fragoulis, G.E., Panayotidis, I. and Nikiphorou, E. (2020) Cardiovascular Risk in Rheumatoid Arthritis and Mechanistic Links: From Pathophysiology to Treatment. Current Vascular Pharmacology, 18, 431-446.
https://doi.org/10.2174/1570161117666190619143842 |
| [48] | Ormseth, M.J., Solus, J.F., Sheng, Q., et al. (2021) Plasma miRNAs Improve the Prediction of Coronary Atherosclerosis in Patients with Rheumatoid Arthritis. Clinical Rheumatology, 40, 2211-2219.
https://doi.org/10.1007/s10067-020-05573-8 |
| [49] | Foinquinos, A., Batkai, S., Genschel, C., et al. (2020) Preclinical Development of a miR-132 Inhibitor for Heart Failure Treatment. Nature Communications, 11, 633. https://doi.org/10.1038/s41467-020-14349-2 |
| [50] | Tanase, D.M., Gosav, E.M., Petrov, D., et al. (2022) MicroRNAs (miRNAs) in Cardiovascular Complications of Rheumatoid Arthritis (RA): What Is New? International Journal of Molecular Sciences, 23, 5254.
https://doi.org/10.3390/ijms23095254 |
| [51] | Ormseth, M.J., Solus, J.F., Vickers, K.C., et al. (2015) Utility of Select Plasma MicroRNA for Disease and Cardiovascular Risk Assessment in Patients with Rheumatoid Arthritis. The Journal of Rheumatology, 42, 1746-1751.
https://doi.org/10.3899/jrheum.150232 |
| [52] | Barbhaiya, M. and Solomon, D.H. (2013) Rheumatoid Arthritis and Cardiovascular Disease: An Update on Treatment Issues. Current Opinion in Rheumatology, 25, 317-324. https://doi.org/10.1097/BOR.0b013e32835fd7f8 |
| [53] | Giollo, A., Bissell, L.A. and Buch, M.H. (2018) Cardio-vascular Outcomes of Patients with Rheumatoid Arthritis Prescribed Disease Modifying Anti-Rheumatic Drugs: A Re-view. Expert Opinion on Drug Safety, 17, 697-708.
https://doi.org/10.1080/14740338.2018.1483331 |
| [54] | Ocon, A.J., Reed, G., Pappas, D.A., et al. (2021) Short-Term Dose and Duration-Dependent Glucocorticoid Risk for Cardiovascular Events in Glucocorticoid-Naive Pa-tients with Rheumatoid Arthritis. Annals of Rheumatic Diseases, 80, 1522-1529. https://doi.org/10.1136/annrheumdis-2021-220577 |
| [55] | Wang, Y., Su, R., Li, B., et al. (2021) Reduction of Pe-ripheral Regulatory T Cells in Active Rheumatoid Arthritis Patients with Coronary Artery Disease. BMC Immunology, 22, 76. https://doi.org/10.1186/s12865-021-00466-0 |
| [56] | Boers, M., Nurmohamed, M.T., Doelman, C.J., et al. (2003) Influence of Glucocorticoids and Disease Activity on Total and High Density Lipoprotein Cholesterol in Patients with Rheumatoid Arthritis. Annals of Rheumatic Diseases, 62, 842-845. https://doi.org/10.1136/ard.62.9.842 |
| [57] | Kisiel, B., Kruszewski, R., Juszkiewicz, A., et al. (2015) Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis. Journal of Immunology Research, 2015, Article ID: 759610.
https://doi.org/10.1155/2015/759610 |
| [58] | 白景芝, 刘永杰. IL-6、RF、ACCP及凝血指标在冠心病合并类风湿关节炎患者中的表达及意义[J]. 中国卫生工程学, 2020, 19(3): 459-461. |
| [59] | Verhoeven, F., Prati, C., Chouk, M., et al. (2021) Methotrexate and Cardiovascular Risk in Rheumatic Diseases: A Comprehensive Review. Expert Review of Clinical Pharmacology, 14, 1105-1112.
https://doi.org/10.1080/17512433.2021.1932461 |
