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成人特发性孤立性ACTH缺乏症合并高血压一例并文献复习
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Abstract:
孤立性ACTH缺乏症(isolated ACTH deficiency, IAD)是一种罕见病，分为获得性孤立性ACTH缺乏症(AIAD)和特发性孤立性ACTH缺乏症(IIAD)，我国目前报道的IAD例数仍较少，因为IAD的临床表现缺乏特异性，多是在给予对症治疗后效果不显著，症状反复出现才得到正确诊断。因此，加深对IAD发病机制、临床表现的了解，熟识其实验室表现、诊断要点至关重要，本文报道一例合并高血压的IIAD患者，并结合文献复习，旨在提高临床医师对该疾病的认识，提高诊出率。
Isolated ACTH deficiency (IAD) is a rare disease, which is divided into acquired isolated ACTH de-ficiency (AIAD) and idiopathic isolated ACTH deficiency (IIAD). The number of reported cases of IAD in China is still relatively small. Because of the lack of specificity of the clinical manifestations of IAD, the correct diagnosis is often made only after symptomatic treatment is given with no significant effect and the symptoms continue to recur. Therefore, it is important to deepen the understanding of the pathogenesis and clinical manifestations of IAD, and we also should be familiar with its laboratory manifestations and diagnostic points. This paper reports a case of IIAD with hypertension, and reviews the literature with the aim of improving clinicians’ understanding of the disease and increasing the diagnosis rate.
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