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小气道功能障碍与哮喘控制
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Abstract:
哮喘是常见的慢性气道炎症性疾病，炎症可累及整个气管–支气管树，近年来，小气道被认为是炎症累及和气流阻塞的主要部位，小气道功能障碍是持续性哮喘的特征，与疾病恶化和控制不良相关，但目前指南尚缺少小气道管理相关内容。本文就小气道功能障碍与哮喘控制关系做一综述，以期提升对小气道功能障碍在哮喘控制中作用的认知水平，为哮喘指南的完善提供支持性证据。
Asthma is a common chronic airway disease. Inflammation in asthma can involve the entire tra-chea-bronchial tree. Recent years, small airways have been accepted to be the main site of inflam-mation and major reason of airflow obstruction. And small airway dysfunction is confirmed as a characteristic of persistent asthma, which is related to exacerbation and control. However, in asth-ma guidelines, little information is stressing the role of small airway. In this review article, we fo-cused on the relationship between small airway dysfunction and asthma control, pointed out the in-fluence of small airway dysfunction in poor asthma control and stressed the importance of its man-agement, in order to provide supporting evidence for asthma guideline.
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