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年龄相关性黄斑变性相关信号通路的研究进展
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Abstract:
年龄相关性黄斑变性(AMD)是主要的致盲眼病之一，它的发病机制暂不明确，研究发现年龄，环境，生活方式，遗传等均是其危险因素。目前针对干性AMD并没有好的治疗方法，而对于湿性AMD最主要的方式也是针对新生血管的抗血管内皮生长因子(VEGF)的治疗。因此研究人员也在积极寻找AMD的发病机制，以期对于AMD有更好的预防及治疗措施。本文介绍了嘌呤能信号通路、Nrf2/Keap1信号通路、Rho/ROCK通路、线粒体自噬信号通路、Ang/Tie信号通路与AMD之间的关系，以期为AMD的治疗及预防提供新的思路。
Age-related macular degeneration (AMD) is one of the leading causes of blindness. The pathogene-sis of AMD is still unclear. Many studies have found that age, environment, lifestyle, and genetics are the risk factors. At present, there is no good treatment for dry AMD, and the main treatment for wet AMD is anti-vascular endothelial growth factor (VEGF) treatment for neovascularization. Therefore, researchers are also actively looking for the pathogenesis of AMD in order to have better prevention and treatment measures for AMD. This article reviews the relationship between purinergic signal-ing pathway, Nrf2/Keap1 signaling pathway, Rho/ROCK signaling pathway, mitautophagy signaling pathway, and Ang/Tie signaling pathway and AMD, in order to provide new ideas for the treatment and prevention of AMD.
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