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非甾体抗炎药相关性肠病的研究进展及诊治
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Abstract:
非甾体抗炎药(nonsteroidal anti-inflammmory drugs, NSAIDs)具有解热镇痛等作用，用于缓解各种关节疼痛、多种发热和心血管疾病。随着NSAIDs的广泛应用，不良反应报道逐渐增多，但关于NSAIDs对肠黏膜损伤的报道却极少，在1966年NSAID (吲哚美辛)引起的小肠损伤才首次发表。近年来，随着双气囊小肠镜(DBE)及视频胶囊内镜(VCE)技术的发展和提高，发现NSAIDs不仅对胃肠道黏膜有损伤，还对小肠黏膜同样有损害作用，但其损伤机制、防治措施尚不明确，需引起重视。因此，本文就非甾体抗炎药相关性肠病作一综述。
Nonsteroidal anti-inflammatory drugs (NSAIDs) have antipyretic and analgesic effects and they are used to relieve various joint pain, fever and cardiovascular diseases. With the wide application of NSAIDs, the reports of adverse reactions have gradually increased, but the reports of NSAIDs on in-testinal mucosal injury are very few. In 1966, the small intestinal injury caused by NSAIDs (indo-methacin) was first published. In recent years, with the development and improvement of dou-ble-balloon enteroscopy (DBE) and video capsule endoscopy (VCE) technology, it has been found that NSAIDs not only damage the gastrointestinal mucosa, but also damage the intestinal mucosa. However, its damage mechanism and prevention and treatment measures are still unclear and need to be paid attention to. Therefore, this article reviews the non-steroidal anti-inflammatory drug-related bowel disease.
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