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m6A与LncRNA之间在胰腺癌中的应用及展望
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Abstract:
胰腺癌是消化道肿瘤中具有侵袭性和致命性的恶性肿瘤，预后差。m6A是最常见转录后修饰，在RNA的输出、翻译、稳定、成熟和衰变起着至关重要的作用。LncRNA是一类转录长度超过200nt的分子，通常情况下不直接参与蛋白质编码过程，而是以RNA的形式参与蛋白质编码基因的调控。对于m6A修饰与lncRNA之间的相关研究也正在进行中。本文围绕m6A与lncRNA在PAAD中的最新研究及进展作一综述。
Pancreatic cancer is an aggressive and lethal malignancy among GI tract tumors with poor prog-nosis. m6A is the most common post-transcriptional modification and plays a crucial role in RNA output, translation, stabilization, maturation and decay. lncRNA is a class of molecules with tran-scriptional length over 200 nt, which normally do not participate in protein coding process directly, but in the form of RNA in protein coding gene regulation. Studies on the correlation between m6A modifications and lncRNAs are also underway. This paper presents a review of the latest research progress between m6A and lncRNA in PAAD, aiming to discuss the latest research and progress between m6A and LncRNA in pancreatic cancer.
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