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突触囊泡膜蛋白2B在胶质瘤研究中的进展
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Abstract:
在中枢神经系统肿瘤中，发病率最高的是胶质瘤。目前对于胶质瘤的治疗有着较为规范的流程，但由于该肿瘤向周围浸润的特点，胶质瘤患者复发率较高且5年生存率仍然不够理想。突触囊泡膜蛋白2B (SV2B)作为一种跨膜糖蛋白在细胞内分泌、递质释放等功能中展现了重要作用。除此之外，最近越来越多的证据表明SV2B作为一种抑制性因素在乳腺癌与胶质瘤的发展过程中展现了重要的调节作用。综上所述，我们总结了突触囊泡膜蛋白2B在胶质瘤中的功能作用、分子机制和临床前景，并提出该蛋白在未来可能成为胶质瘤患者治疗和预后的有用目标。
Among central nervous system tumors, the highest incidence is glioma. At present, there is a rela-tively standardized process for the treatment of glioma. However, due to the characteristics of tu-mor infiltration, the recurrence rate of glioma patients is high and the 5-year survival rate is still not ideal. As a transmembrane glycoprotein, synaptic vesicle membrane protein 2B (SV2B) plays an important role in cell endocrine and transmitter release. In addition, more and more evidence has recently shown that SV2B as an inhibitory factor plays an important role in the development of breast cancer and glioma. In summary, we summarize the functional role, molecular mechanisms, and clinical perspectives of synaptic vesicle membrane protein 2B in glioma and propose that this protein may be a useful therapeutic and prognostic target for glioma patients in the future.
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